Prognostic Value of Baseline CT Perfusion Parameters of Pancreatic Cancer for Patients Undergoing Stereotactic Body Radiotherapy or Surgical Resection
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 6
- 试验地点
- 1
- 主要终点
- Histological markers of tumor angiogenesis (microvessel density, EGF/VEGF expression level)
研究概览
简要总结
The purpose of this study is first, to determine whether baseline perfusion characteristics of pancreatic cancer, as characterized by CT perfusion studies, can predict tumor response to treatment by stereotactic body radiotherapy (SBRT). The second goal of this study is to determine whether baseline perfusion characteristics in those patients with resectable pancreatic cancer correlate with immunohistologic markers of angiogenesis such as microvessel density and vascular endothelial growth factor (VEGF) expression.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •suspected and/or biopsy-proven pancreatic adenocarcinoma, and
- •referral to Radiology for pre-treatment baseline pancreatic protocol CT.
- •Exclusion criteria:
- •are absolute contraindications to intravenous iodinated contrast or CT scan.
排除标准
- 未提供
结局指标
主要结局
Histological markers of tumor angiogenesis (microvessel density, EGF/VEGF expression level)
时间窗: 1 day
Tumor response to treatment in SBRT patients, based on WHO criteria (No Change/Progressive Disease vs. Partial/Complete Response)
时间窗: 1 year
次要结局
未报告次要终点