Comparison of Clinical Outcomes Between Left Atrial Appendage Occlusion With Dual Antiplatelet Therapy Versus Conventional Antithrombotic Therapy in Patients With Atrial Fibrillation Undergoing Drug-eluting Stent Implantation
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 480
- 主要终点
- Composite of stroke and major bleeding
研究概览
简要总结
This study will retrospectively review and compare clinical outcomes between left atrial appendage occlusion with dual antiplatelet therapy versus conventional antithrombotic therapy in patients with atrial fibrillation undergoing drug-eluting stent implantation.
详细描述
Composite of stroke and major bleeding will be compared after adjusting those groups using inverse probability weighted model.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients with AF who underwent PCI and treated with LAAO and DAPT or conventional antithrombotic therapy
排除标准
- 未提供
结局指标
主要结局
Composite of stroke and major bleeding
时间窗: From date of index procedure until the date of primary endpoint occur or date of last follow up, whichever came first, assessed up to 50 months
Primary endpoint is a composite of stroke and major bleeding. Stroke is defined as ischemic cerebrovascular event included both transient ischemic attack and ischemic cerebral infarction. Major bleeding event was defined as moderate or severe bleeding according to the Global Utilization of Streptokinase and Tissue Plasminogen Activator for Occluded Coronary Arteries criteria.
次要结局
未报告次要终点
研究者
Dr. Cheol Woong Yu
Professor
Korea University Anam Hospital