A Study of 18F-AV-45 in Alzheimer's Disease (AD) and Healthy Volunteers
- Registration Number
- NCT01565343
- Lead Sponsor
- Avid Radiopharmaceuticals
- Brief Summary
This study will test if two AV-45 PET scans up to 4 weeks apart in AD subjects and healthy volunteers provide the same results. The study will also test two different AV-45 injection methods in a small subgroup of enrolled AD subjects (slow vs. fast bolus group).
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 25
Inclusion Criteria
Not provided
Exclusion Criteria
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Healthy controls florbetapir F 18 Healthy male or female subjects; 35-55 years old. Two bolus IV injections followed by brain PET scan up to 4 weeks apart AD Subjects florbetapir F 18 Two bolus IV injections followed by brain PET scan up to 4 weeks apart AD Subjects: Slow vs. Fast Bolus florbetapir F 18 Two bolus IV injections followed by a brain PET scan up to 4 weeks apart. The first injection given as a rapid bolus (\< 5 second injection, with immediate flush). The second injection given as a slow bolus (approximately 20 to 30 second injection with a flush delayed by 10 seconds after dose administration).
- Primary Outcome Measures
Name Time Method Mean Cortical to Cerebellum SUVR 50-70 min after injection Standardized Uptake Value ratio (SUVR) is the ratio of tracer uptake in predefined cortical regions, relative to uptake in the whole cerebellum.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Research Site
🇺🇸North East, Maryland, United States