Evaluation of Novel Lung Function Parameters in Patients With Pulmonary Hypertension (PH)

Completed

• Conditions: Pulmonary Hypertension

• Registration Number: NCT03667794
• Lead Sponsor: Universitätsmedizin Mannheim

Brief Summary

Little is known about affection of small airways in patients with pulmonary hypertension as well as the ideal diagnostic approach. The investigators therefore aimed to evaluate novel or not widely used lung function tests for the evaluation of airway function in patients with PH.

Detailed Description

Not available

Study Timeline

• Study Start: 2015-07-01
• Primary Completion: 2017-07-31
• Study Completion: 2017-07-31
• Status Verified: 2018-09
• Study First Submitted: 2018-09-06
• Study First Submitted QC: 2018-09-10
• Study First Posted: 2018-09-12
• Last Update Submitted: 2018-09-12
• Last Update Posted: 2018-09-14

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 75

Inclusion Criteria

• known or first diagnosis of PH

Exclusion Criteria

• inability to perform lung function testing
• unable or unwilling to participate

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
LCI	30 minutes	between-group difference in lung clearance index (LCI)
D5-20	30 minutes	between-group difference in frequency dependence of resistance (D5-20)

Secondary Outcome Measures

Name	Time	Method
Discrimination small airway resistance	30 minutes	Evaluation of discriminative capability of impulse oscillometry
Discrimination ventilation heterogeneity	30 minutes	Evaluation of discriminative capability of multiple breath washout