Succinylcholine vs Rocuronium for Prehospital Emergency Intubation : a Randomized Trial
试验速览
- 阶段
- 3 期
- 状态
- 已完成
- 发起方
- 入组人数
- 1,321
- 试验地点
- 18
- 主要终点
- First-pass intubation success rate
研究概览
简要总结
All adult patients with spontaneous cardiac activity and requiring tracheal intubation in the pre hospital emergency context will be included in order to compare the use of succinylcholine vs Rocuronium for prehospital emergency intubation.
详细描述
All adult patients with spontaneous cardiac activity and requiring tracheal intubation in the pre hospital emergency context will be included. All intubation will be performed by an emergency physician or a nurse specialized in anesthesia. For patients with spontaneous cardiac activity, rapid sequence intubation will be performed to allow intubation.
Comparisons studied will be : Intubation success rate at the first laryngoscopy, glottis exposure assessed by Cormack and Lehane classification, difficult intubation rate assessed by the Intubation Difficult Score (IDS), the conditions of intubation assessed by the Copenhagen score, the need for alternative airway techniques and the immediate post intubation complications rate as vomiting, dental trauma, pulmonary inhalation, arterial desaturation , hypotension episodes and cardiac arrest occurrence.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •All adult patients with spontaneous cardiac activity and requiring tracheal intubation in the pre hospital emergency context
排除标准
- •Patients in cardiac arrest;
- •Patients under-18s;
- •Patients under guardianship ;
- •Pregnancy known;
- •Patients with cons to one of the following three drugs: rocuronium, succinylcholine, sugammadex;
- •Patients not affiliated to a social security scheme (beneficiary or legal).
研究组 & 干预措施
Administration of Succinylcholine
Intubation after IV administration of Succinylcholine 1mg/kg
干预措施: Succinylcholine : 1mg/kg (Drug)
Administration of Rocuronium
Intubation after IV administration of Rocuronium 1.2 mg/kg
干预措施: Rocuronium : 1.2 mg/kg (Drug)
结局指标
主要结局
First-pass intubation success rate
时间窗: between 1 hour to 3 hours after inclusion
Measured by the proportion of successful intubation in the first laryngoscopy.
次要结局
- Incidence of difficult intubation(between 1 hour to 3 hours after inclusion)
- Intubation conditions assessment(between 1 hour to 3 hours after inclusion)
- Need for alternate airway devices(between 1 hour to 3 hours after inclusion)
- early intubation-related complications(between 1 hour to 3 hours after inclusion)