Association Between Interleukin-6 and Thyroid Hormone Dysfunction in Patients With Chronic Kidney Disease Undergoing Hemodialysis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 65
- 试验地点
- 2
- 主要终点
- Correlation between serum Interleukin-6 (IL-6) concentration and serum Thyroid-Stimulating Hormone (TSH) levels
研究概览
简要总结
Chronic kidney disease (CKD) is often associated with multiorgan complications, including thyroid hormone dysfunction. Interleukin-6 (IL-6), a pro-inflammatory cytokine, has been proposed as a marker of inflammation that may contribute to these alterations. The main question it aims to answer is:
Is there an association between interleukin-6 and thyroid hormone dysfunction in patients with chronic kidney disease (CKD) Blood samples will be collected and analyzed from 65 patients who have undergone hemodialysis for at least 3 months.
详细描述
This cross-sectional observational study involves patients with CKD undergoing hemodialysis at Airlangga University Hospital. Data were collected based on their medical record and Blood test for IL-6. Linear regression analysis assessed the relationship between IL-6 levels and thyroid function parameters.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 21 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age 21 Years Old and above
- •Patients with ESRD who have undergone hemodialysis for ≥ 3 months and are in stable condition.
- •Patients are able to communicate and respond to questions appropriately
- •Patients are willing to participate in the study.
排除标准
- •ESRD patients undergoing hemodialysis who have been diagnosed with underlying thyroid disorders or thyroid malignancy.
- •Patients with a history of thyroid surgery or any intervention involving the thyroid gland.
- •Patients with a family history of thyroid disorders.
- •Patients taking medications that affect thyroid function or using antioxidant drugs.
- •Patients with infection or sepsis.
结局指标
主要结局
Correlation between serum Interleukin-6 (IL-6) concentration and serum Thyroid-Stimulating Hormone (TSH) levels
时间窗: At baseline, during routine hemodialysis visit (prior to any study-specific intervention)
Serum IL-6 (pg/mL) and TSH (µIU/mL) will be measured using standardized hospital laboratory immunoassay analyzers. The outcome is the correlation coefficient (Spearman r) between IL-6 and TSH.
次要结局
- Correlation between serum IL-6 concentration and serum Total Triiodothyronine (T3) levels(At baseline, during routine hemodialysis visit (prior to any study-specific intervention))
- Correlation between serum IL-6 concentration and serum Total Thyroxine (T4) levels(At baseline, during routine hemodialysis visit (prior to any study-specific intervention))
- Correlation between serum IL-6 concentration and Free Triiodothyronine (fT3) levels(At baseline, during routine hemodialysis visit (prior to any study-specific intervention))
- Correlation between serum IL-6 concentration and Free Thyroxine (fT4) levels(At baseline, during routine hemodialysis visit (prior to any study-specific intervention))