Prevalence and Risk Factors for Coxiella Burnetii Seropositivity (Q Fever) Among Adults in Western France

• Conditions: Q Fever
• Interventions: Other: blood test

• Registration Number: NCT03334019
• Lead Sponsor: Nantes University Hospital

Brief Summary

Diseases naturally transmitted between animals and humans (zoonoses) are one of the leading causes of emergence or re-emergence of human infectious diseases. Non-foodborne zoonoses are commonly transmitted to human directly by contact with infected animals or contaminated environment. People working with animals such as farmers and veterinarians are particularly at risk of infection. Some zoonoses can also be transmitted indirectly thought the air and therefore can affect the general population. Example is Q fever, a disease caused by Coxiella burnetii, a bacterium highly resistant in the environment.

In Western France, Q fever is endemic in cattle herds. To improve human zoonotic disease surveillance, the investigators will conduct a population based study in this area.

The aims of the study are:

1. To assess seroprevalence of Coxiella burnetii infection among general population, farmers and veterinarians in Western France

2. To identify risk factors for Coxiella burnetii seropositivity in these populations

Detailed Description

In order to estimate seroprevalence and risk factors for Coxiella burnetii infection in humans, the investigators will conduct a cross-sectional study in three groups:

* blood donors at blood donation organizations (general population)

* beef and dairy cattle farmers

* veterinarians involved in a rural practice

All the participants in the study will provide a blood sample and will fill in a questionnaire.

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study First Submitted: 2017-11-02
• Study Start: 2017-11-06
• Study First Submitted QC: 2017-11-06
• Study First Posted: 2017-11-07
• Status Verified: 2018-05
• Primary Completion: 2018-05-05
• Last Update Submitted: 2018-05-28
• Last Update Posted: 2018-05-30
• Study Completion: 2019-11

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 559

Inclusion Criteria

• Give a written informed consent
• Be 18 years old and over
• Be able to speak French

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Exclusion Criteria

• Adults under protection (guardianship or curators)
• Contraindication for drawing blood

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
subjects	blood test	Data collected on general population, farmers and veterinarians though questionnaires and blood samples.

Primary Outcome Measures

Name	Time	Method
Antibody titers against Coxiella burnetii in general population in Western France	Day 0	Blood samples will be taken on blood donors for detection of Coxiella burnetii antibodies by indirect immunofluorescence assay.
Antibody titers against Coxiella burnetii in farmers population in Western France	Day 0	Blood samples will be taken on farmers for detection of Coxiella burnetii antibodies by indirect immunofluorescence assay.
Antibody titers against Coxiella burnetii in veterinarians population in Western France	Day 0	Blood samples will be taken on veterinarians for detection of Coxiella burnetii antibodies by indirect immunofluorescence assay.

Secondary Outcome Measures

Name	Time	Method
Measure of association between Coxiella burnetii seropositivity risk and socio-demographic	Day 0	A short questionnaire will be filled in by participants (general population) to collect socio-demographic, lifestyle and occupational factors.
Measure of association between Coxiella burnetii seropositivity risk and lifestyle	Day 0	A short questionnaire will be filled in by participants (farmers) to collect socio-demographic, lifestyle and occupational factors.
Measure of association between Coxiella burnetii seropositivity in humans (general population) and cattle herds' prevalence of Coxiella burnetii infection.	Day 0	Besides blood samples taken on participants, blood samples and milk samples will be taken on beef and dairy cattle herds, respectively, to determine the prevalence of Coxiella burnetii infection in cattle herds.
Measure of association between Coxiella burnetii seropositivity risk and occupational factors.	Day 0	A short questionnaire will be filled in by participants (veterinarians) to collect socio-demographic, lifestyle and occupational factors.
Measure of association between Coxiella burnetii seropositivity in humans ( veterinarians) and cattle herds' prevalence of Coxiella burnetii infection.	Day 0	Besides blood samples taken on participants, blood samples and milk samples will be taken on beef and dairy cattle herds, respectively, to determine the prevalence of Coxiella burnetii infection in cattle herds.
Measure of association between Coxiella burnetii seropositivity in humans (farmers) and cattle herds' prevalence of Coxiella burnetii infection.	Day 0	Besides blood samples taken on participants, blood samples and milk samples will be taken on beef and dairy cattle herds, respectively, to determine the prevalence of Coxiella burnetii infection in cattle herds.

Trial Locations

Locations (1)

CHU de Nantes; 🇫🇷 Nantes, France