Prevalence and Risk Factors for Coxiella Burnetii Seropositivity (Q Fever) Among Adults in Western France
试验速览
- 阶段
- 不适用
- 入组人数
- 559
- 试验地点
- 1
- 主要终点
- Antibody titers against Coxiella burnetii in general population in Western France
研究概览
简要总结
Diseases naturally transmitted between animals and humans (zoonoses) are one of the leading causes of emergence or re-emergence of human infectious diseases. Non-foodborne zoonoses are commonly transmitted to human directly by contact with infected animals or contaminated environment. People working with animals such as farmers and veterinarians are particularly at risk of infection. Some zoonoses can also be transmitted indirectly thought the air and therefore can affect the general population. Example is Q fever, a disease caused by Coxiella burnetii, a bacterium highly resistant in the environment.
In Western France, Q fever is endemic in cattle herds. To improve human zoonotic disease surveillance, the investigators will conduct a population based study in this area.
The aims of the study are:
- To assess seroprevalence of Coxiella burnetii infection among general population, farmers and veterinarians in Western France
- To identify risk factors for Coxiella burnetii seropositivity in these populations
详细描述
In order to estimate seroprevalence and risk factors for Coxiella burnetii infection in humans, the investigators will conduct a cross-sectional study in three groups:
- blood donors at blood donation organizations (general population)
- beef and dairy cattle farmers
- veterinarians involved in a rural practice
All the participants in the study will provide a blood sample and will fill in a questionnaire.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Give a written informed consent
- •Be 18 years old and over
- •Be able to speak French
排除标准
- •Adults under protection (guardianship or curators)
- •Contraindication for drawing blood
结局指标
主要结局
Antibody titers against Coxiella burnetii in general population in Western France
时间窗: Day 0
Blood samples will be taken on blood donors for detection of Coxiella burnetii antibodies by indirect immunofluorescence assay.
Antibody titers against Coxiella burnetii in farmers population in Western France
时间窗: Day 0
Blood samples will be taken on farmers for detection of Coxiella burnetii antibodies by indirect immunofluorescence assay.
Antibody titers against Coxiella burnetii in veterinarians population in Western France
时间窗: Day 0
Blood samples will be taken on veterinarians for detection of Coxiella burnetii antibodies by indirect immunofluorescence assay.
次要结局
- Measure of association between Coxiella burnetii seropositivity risk and socio-demographic(Day 0)
- Measure of association between Coxiella burnetii seropositivity risk and lifestyle(Day 0)
- Measure of association between Coxiella burnetii seropositivity in humans (general population) and cattle herds' prevalence of Coxiella burnetii infection.(Day 0)
- Measure of association between Coxiella burnetii seropositivity risk and occupational factors.(Day 0)
- Measure of association between Coxiella burnetii seropositivity in humans ( veterinarians) and cattle herds' prevalence of Coxiella burnetii infection.(Day 0)
- Measure of association between Coxiella burnetii seropositivity in humans (farmers) and cattle herds' prevalence of Coxiella burnetii infection.(Day 0)