The effect of biological and environmental factors on the course of cognition in First Episode Schizophrenia patients and High Risk Subjects
- Conditions
- psychosisschizophrenia10013511
- Registration Number
- NL-OMON31164
- Lead Sponsor
- Academisch Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 150
Inclusion Criteria
The First Episode Schizophrenia patients will have to meet the DSM-IV criteria for schizophrenia and this diagnosis should not have been assessed in the past.
The Ultra High Risk patients will be assessed using the Structured Interview of Prodromal Symptoms (SIPS) and
Exclusion Criteria
pregnancy,
metals in the body contraindicated in MRI inverstigation
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The most important study parameters are the results of the cognitive test<br /><br>battery MATRICS with an interval of 1 year. Using the MATRICS the course of<br /><br>cognitive functioning can be assessed and in the High Risk group, the persons<br /><br>that make the transition to psychosis can be tested for changes in cognitive<br /><br>functioning</p><br>
- Secondary Outcome Measures
Name Time Method <p>The secundary study parameters are the biological data (MRI, genetics),<br /><br>behavioral data (Pre Pulse Inhibition) and environmental data (cannabis use)<br /><br>that are linked to the cognitive data. In this manner potential predisposing<br /><br>factors for cognitive functioning can be identified. </p><br>