Comparison of Thyroid Volumes in Patients With and Without Endometrioma

Not Applicable

Completed

• Conditions: Thyroid; Endometrioma
• Interventions: Other: Evaluating Thyroid Volumes by ultrasonography

• Registration Number: NCT05323539
• Lead Sponsor: Adana City Training and Research Hospital

Brief Summary

The aim of our study is to evaluate whether there is a statistical difference between thyroid gland volume in patients with pathological diagnosis of endometriosis or endometrioma and in patients who underwent surgery for other gynecological reasons, and to reveal the presence of concomitant thyroid disease in these cases.

Detailed Description

Transcripts and proteins involved in thyroid metabolism are dysregulated in the eutopic and ectopic endometrium of endometriotic patients, leading to triiodothyronine (T3) action, resistance, and local thyroxine (T4) accumulation of the ectopic endometrium. Thyroid stimulating hormone (TSH) acts as a proliferative and prooxidative hormone in all endometriums of endometriosis patients and controls. Mouse studies have confirmed that endometriotic implants are larger when thyroid hormones are increased.

Since endometriosis is characterized by a chronic inflammatory process, the high prevalence of autoimmune thyroid diseases in patients with endometriosis may be the result of immune dysregulation observed in women with endometriosis (5). Thyroid involvement has already been described in the physiology of the endometrium and ovary, and thyroid diseases are often associated with gynecological and obstetric disorders such as infertility, miscarriage or preterm delivery.

Despite all the links between thyroid diseases and endometriosis, there is no study related to thyroid volume in patients with endometriosis so far. Thyroid volume was studied in patients with diabetes mellitus, pregnant women, and scleroderma. We believe that the evaluation of thyroid volume in patients with endometriosis will contribute to the investigation of the relationship between these two pathogenesis, and to the treatment and follow-up approach.

Study Timeline

• Study Start: 2021-09-20
• Study First Submitted: 2022-04-05
• Study First Submitted QC: 2022-04-05
• Study First Posted: 2022-04-12
• Primary Completion: 2022-05-20
• Study Completion: 2022-07-20
• Status Verified: 2023-07
• Last Update Submitted: 2023-07-28
• Last Update Posted: 2023-08-01

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 60

Inclusion Criteria

• Prediagnosis of surgically planned endometrioma

Exclusion Criteria

• Patients with goiteri,
• Patients with past or present autoimmune thyroid dysfunction,
• Patietns on treatment with thyroid hormones or drugs containing iodine.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Control group	Evaluating Thyroid Volumes by ultrasonography	Patients who had planned gynecological surgery for a reason (ovarian cycts) other than endometrioma
Patients with endometrioma	Evaluating Thyroid Volumes by ultrasonography	Patients having a prediagnosis of surgically planned endometrioma occured this group.

Primary Outcome Measures

Name	Time	Method
Measuring Thyroid Volumes by ultrasonography	6 months	Longitudinal and transverse scans are performed allowing the measurement of the depth, the width and the length of each lobe. The ellipsoid formula is used. The thyroid volume is the sum of the both lobes excluding isthmus. All measurements are performed bt one experienced radiologist.

Trial Locations

Locations (1)

Adana City Education and Research Hospital; 🇹🇷 Adana, Merkez, Turkey