A Study of Baricitinib in Participants With Systemic Lupus Erythematosus (SLE)
- Registration Number
- NCT03843125
- Lead Sponsor
- Eli Lilly and Company
- Brief Summary
The reason for this long term study is to see how safe and effective the study drug known as baricitinib is in participants with systemic lupus erythematosus (SLE) who have completed the final treatment visit of study I4V-MC-JAHZ (NCT03616912) or study I4V-MC-JAIA (NCT03616964).
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- TERMINATED
- Sex
- All
- Target Recruitment
- 1147
- Have completed the final treatment study visit of an originating study, such as study JAHZ (NCT03616912) or Study JAIA (NCT03616964).
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Placebo to 2 mg Baricitinib Placebo Participants who received placebo in the originating study (JAHZ or JAIA) were randomized to receive 2 mg Baricitinib administered orally QD. Placebo to 4 mg Baricitinib Placebo Participants who received placebo in the originating study (JAHZ or JAIA) were randomized to receive 4 mg Baricitinib administered orally QD. 4 mg Baricitinib Placebo Participants received one 4 mg Baricitinib tablet and one placebo tablet matching 2 mg Baricitinib administered orally QD. 2 mg Baricitinib Placebo Participants received one 2 mg Baricitinib tablet and one placebo tablet matching 4 mg Baricitinib administered orally every day (QD). 4 mg Baricitinib Baricitinib Participants received one 4 mg Baricitinib tablet and one placebo tablet matching 2 mg Baricitinib administered orally QD. 2 mg Baricitinib Baricitinib Participants received one 2 mg Baricitinib tablet and one placebo tablet matching 4 mg Baricitinib administered orally every day (QD). Placebo to 2 mg Baricitinib Baricitinib Participants who received placebo in the originating study (JAHZ or JAIA) were randomized to receive 2 mg Baricitinib administered orally QD. Placebo to 4 mg Baricitinib Baricitinib Participants who received placebo in the originating study (JAHZ or JAIA) were randomized to receive 4 mg Baricitinib administered orally QD.
- Primary Outcome Measures
Name Time Method Percentage of Participants With Permanent Investigational Product Discontinuations Week 134 Percentage of participants with permanent investigational product discontinuations.
Percentage of Participants With Serious Adverse Events (SAEs) Week 134 Percentage of participants with SAEs. An SAE is any AE from this study that results in one of the following outcomes: Death; Initial or prolonged inpatient hospitalization; A life-threatening experience (that is, immediate risk of dying); Persistent or significant disability/incapacity; Congenital anomaly/birth defect; Important medical events that may not be immediately life-threatening or result in death or hospitalization, but may jeopardize the patient or may require intervention to prevent one of the other outcomes listed in the definition above.
A summary of all SAE's, regardless of causality, is located in the Reported Adverse Events section.Percentage of Participants With Temporary Investigational Product Interruptions Week 134 Percentage of participants with temporary investigational product interruptions.
Percentage of Participants With Treatment-Emergent Adverse Events (TEAEs) Week 134 Percentage of participants with TEAEs. A treatment-emergent AE (TEAE) is defined as an event that first occurred or worsened in severity after the first dose of study treatment in Study JAIM and on or prior to the last visit date during the analysis period. The analysis period is defined as the treatment period plus up to 30 days off-drug follow-up time.
A summary of serious and other non-serious adverse events, regardless of causality, is located in the Reported Adverse Events module.Percentage of Participants With Adverse Events of Special Interest (AESIs) Week 134 Percentage of Participants with AESIs. AESI consisted of infections, positively adjudicated arterial thromboembolic events (ATE), positively adjudicated venous thromboembolic events (VTE), positively adjudicated major adverse cardiovascular events (MACE), other positively adjudicated cardiovascular events, death, anaphylactic reactions, hypersensitivity, angioedema, and malignancies.
- Secondary Outcome Measures
Name Time Method Annualized Safety of Estrogens in Lupus Erythematosus National Assessment (SELENA)-Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) Flare Index Flare Rate Baseline through Week 48 The SELENA-SLEDAI tool is a cumulative and weighted index used to assess disease activity across 24 different disease descriptors in patients with lupus. A patient's SELENA-SLEDAI total score is the sum of all marked lupus related descriptors (seizure, psychosis, organic brain syndrome, visual disturbance, cranial nerve disorder, lupus headache, cerebrovascular accident, vasculitis, arthritis, myositis, urinary casts, hematuria, proteinuria, pyuria, new rash, alopecia, mucosal ulcers, pleurisy, pericarditis, low complement, increased DNA binding, fever, thrombocytopenia, leukopenia). A total score can fall between 0 and 105, with a higher score representing a more significant degree of disease activity. The annualized flare rate is calculated as the number of flares divided by the flare exposure time in days multiplied with 365.25.
Percentage of Participants With Cutaneous Lupus Erythematosus Disease Area and Severity Index (CLASI) Total Activity Score ≥10 at Baseline With ≥50% Reduction in CLASI Total Activity Score Week 48 The CLASI is a single-page tool that separately quantifies disease activity and damage. For the activity score, points are given for the presence of erythema, scale, mucous membrane lesions, recent hair loss, and inflammatory alopecia. The total score represents the sum of the individual scores and ranges from 0 to 70. Higher scores are awarded for more severe manifestations.
Percentage of Participants Achieving a Systemic Lupus Erythematosus Responder Index 4 (SRI-4) Response Week 134 SRI-4 response defined as 1)greater than or equal to 4-point reduction in Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K) total score 2)no new British Isles Lupus Assessment Group (BILAG) A and no more than 1 new BILAG B domain score and 3)no worsening in Physician Global Assessment (PGA) of Disease Activity (worsening defined as an increase of \>=0.3 from baseline on a 0-3 visual analogue scale).
SLEDAI-2K assessment consists of 24 items with total score of 0(no symptoms) to 105 (presence of all defined symptoms) with higher scores representing increased disease activity. BILAG Index: assessing clinical signs, symptoms,or laboratory parameters related to Systemic Lupus Erythematosus (SLE),divided into 9 organ systems. For each organ system A=severe disease,B=moderate disease,C=mild stable disease,D=inactive,but previously active,E=inactive and never affected. PGA assesses disease activity on a visual analogue scale from 0 to 3 (1=mild, 2=moderate, 3=severe).Change From Baseline in Tender Joint Count Baseline through Week 48 The number of tender and painful joints is determined by examination of 28 joints (14 on each side) which include: the 2 shoulders, the 2 elbows, the 2 wrists, the 10 metacarpophalangeal joints, the 2 interphalangeal joints of the thumb, the 8 proximal interphalangeal joints, and the 2 knees. The joints are assessed and classified as tender or not tender. LS mean was calculated using Mixed Model Repeated Measures (MMRM) analysis with treatment, baseline disease activity (total SLEDAI-2K \<10; \>=10), baseline corticosteroid dose (\<10 mg/day; \>=10 mg/day prednisone or equivalent), region (North America, Central/South America/Mexico, Europe, Asia and Rest of World), visit (as categorical variable), baseline value, treatment-by-visit interaction, and baseline value-by-visit interaction.
Change From Baseline in Swollen Joint Count Baseline trough Week 48 The number of swollen joints is determined by examination of 28 joints (14 on each side) which include: the 2 shoulders, the 2 elbows, the 2 wrists, the 10 metacarpophalangeal joints, the 2 interphalangeal joints of the thumb, the 8 proximal interphalangeal joints, and the 2 knees. The joints are assessed and classified as swollen or not swollen. LS mean was calculated using MMRM analysis with treatment, baseline disease activity (total SLEDAI-2K \<10; \>=10), baseline corticosteroid dose (\<10 mg/day; \>=10 mg/day prednisone or equivalent), region (North America, Central/South America/Mexico, Europe, Asia and Rest of World), visit (as categorical variable), baseline value, treatment-by-visit interaction, and baseline value-by-visit interaction.
Change From Baseline in Worst Pain Numeric Rating Scale (NRS) Baseline through Week 48 Change from baseline in Worst Pain NRS. It is assessed using an 11-point Numeric Rating Scale (NRS) (0-10) where 0 represents "no pain" and 10 represents "worst pain imaginable". Overall severity of a patient's pain is indicated by selecting the number that best describes the worst level of pain during the past 7 days.
Percentage of Participants Achieving a Lupus Low Disease Activity State (LLDAS) Week 48 Percentage of participants achieving a LLDAS. The LLDAS is a composite measure designed to identify patients achieving a state of low disease activity. The LLDAS response criteria were: (1) SLEDAI-2K \<=4, with no activity in major organ systems (CNS, vascular, renal, cardiorespiratory and constitutional); where "no activity" is defined as all items of SLEDAI-2K within these major organ systems equal to 0. (2) no new features of lupus disease activity compared to previous occurred visit, where the "new feature" is defined as any of the SLEDAI-2K 24 items changed from 0 to greater than 0; (3) PGA (scale 0-3), \<=1; (4) current prednisolone (or equivalent) dose \<=7.5 mg daily.
Change From Baseline in Prednisone Dose Baseline through Week 48 Change from baseline in prednisone dose.
Change From Baseline in Systemic Lupus International Collaborating Clinics/American College of Rheumatology (SLICC/ACR) Damage Index Total Score Baseline through Week 48 The SLICC/ACR damage index is a validated instrument to assess damage, defined as irreversible impairment, continuously persistent for 6 months (ascertained by clinical assessment), occurring since the onset of lupus, and it is based on a weighted scoring system. This index records damage occurring in participants with SLE regardless of cause, with demonstrated content, face, criterion, and discriminant validity. A score of 0 indicates no damage. Total maximum score is 47 and increasing score indicates increasing disease severity.
Trial Locations
- Locations (296)
New England Research Associates
🇺🇸Bridgeport, Connecticut, United States
Metroplex Clinical Research Center
🇺🇸Dallas, Texas, United States
Integral Rheumatology & Immunology Specialists
🇺🇸Plantation, Florida, United States
Emory University
🇺🇸Atlanta, Georgia, United States
Millennium Research
🇺🇸Ormond Beach, Florida, United States
North Georgia Rheumatology, PC
🇺🇸Lawrenceville, Georgia, United States
Paramount Medical Research
🇺🇸Middleburg Heights, Ohio, United States
Johns Hopkins Asthma and Allergy Center
🇺🇸Baltimore, Maryland, United States
Columbia University Medical Center
🇺🇸New York, New York, United States
MD Medical Corporation
🇺🇸Hemet, California, United States
Advanced Rheumatology, PC
🇺🇸Lansing, Michigan, United States
The Feinstein Institute for Medical Research
🇺🇸Manhasset, New York, United States
St. Lawrence Health System
🇺🇸Canton, New York, United States
ACRC Studies
🇺🇸Poway, California, United States
Arthritis and Osteoporosis Associates of New Mexico
🇺🇸Las Cruces, New Mexico, United States
Allied Clinical Research
🇺🇸Reno, Nevada, United States
NYU Langone
🇺🇸New York, New York, United States
Wallace Rheumatic Studies Center
🇺🇸Beverly Hills, California, United States
Clinical Research Institute of Michigan, LLC
🇺🇸Saint Clair Shores, Michigan, United States
Immanuel Krankenhaus Rheuma Klinik Berlin Buch
🇩🇪Berlin, Germany
Charité Campus Virchow-Klinikum
🇩🇪Berlin, Germany
University General Hospital of Heraklion
🇬🇷Heraklion, Irakleío, Greece
Debreceni Egyetem Klinikai Kozpont
🇭🇺Debrecen, Hungary
Gen. Hosp. of Thessaloniki "Hippokration"
🇬🇷Thessaloniki, Greece
Azienda Ospedaliera Santa Maria Della Misericordia
🇮🇹Udine, Italy
Universitatsklinikum Leipzig
🇩🇪Leipzig, Sachsen, Germany
Universitaetsklinikum Koeln
🇩🇪Köln, Germany
Qualiclinic
🇭🇺Budapest, Hungary
Fondazione IRCCS Ca'Granda Ospedale Maggiore Policlinico
🇮🇹Milano, Italy
Azienda Policlinico Umberto I
🇮🇹Roma, Italy
Cantonal Hospital St.Gallen
🇨🇭st.Gallen, Sankt Gallen, Switzerland
Hualien Tzu-Chi Hospital
🇨🇳Dalin Township, Taiwan
Showa University Hospital
🇯🇵Shinagawa, Tokyo, Japan
Gachon University Gil Hospital
🇰🇷Incheon, Korea, Korea, Republic of
Hospital Universitari Vall d'Hebron
🇪🇸Barcelona, Barcelona [Barcelona], Spain
Mary Mediatrix Medical Center
🇵🇭Lipa, Batangas, Philippines
Jakaranda Hospital
🇿🇦Pretoria, Gauteng, South Africa
Hanyang University Medical Center
🇰🇷Seoul, Korea, Korea, Republic of
Seoul St. Mary's Hospital
🇰🇷Seoul, Korea, Korea, Republic of
Morales Vargas Centro de Investigacion, S.C.
🇲🇽Leon, Guanajuato, Mexico
Clinica para el Diagnostico y Tratamiento de la Enfermedades
🇲🇽Mexico City, Distrito Federal, Mexico
Kyung Pook National University Hospital
🇰🇷Daegu, Korea, Korea, Republic of
Asan Medical Center
🇰🇷Seoul, Korea, Korea, Republic of
WITS Clinical Research
🇿🇦Johannesburg, Gauteng, South Africa
Zespol Poradni Specjalistycznych REUMED
🇵🇱Lublin, Polska, Poland
University Of Pretoria
🇿🇦Pretoria, South Africa
Suite 509 Umhlanga Netcare Medical Centre
🇿🇦Umhlanga, Durban, South Africa
Whipps Cross University Hospital
🇬🇧Leytonstone, London, United Kingdom
Chi-Mei Medical Center
🇨🇳Tainan City, Taiwan
Doncaster and Bassetlaw Teaching Hospitals NHS Foundation Trust
🇬🇧Doncaster, United Kingdom
Rheumatology Center Of Houston
🇺🇸Houston, Texas, United States
Arthritis Clinic of Northern VA, P.C.
🇺🇸Arlington, Virginia, United States
Spectrum Medical Inc.
🇺🇸Danville, Virginia, United States
Rheumatic Disease Center
🇺🇸Glendale, Wisconsin, United States
Medvin Clinical Research - Weidmann
🇺🇸Whittier, California, United States
Providence Medical Foundation
🇺🇸Fullerton, California, United States
Arthritis and Rheumatic Disease
🇺🇸Aventura, Florida, United States
Clinical Research of West Florida, Inc. (Clearwater)
🇺🇸Clearwater, Florida, United States
Lakes Research, LLC
🇺🇸Miami Lakes, Florida, United States
IRIS Research and Development, LLC
🇺🇸Plantation, Florida, United States
SUNY Upstate Medical University
🇺🇸Syracuse, New York, United States
Joint and Muscle Medical Care
🇺🇸Charlotte, North Carolina, United States
Medication Management
🇺🇸Greensboro, North Carolina, United States
Box Arthritis & Rheumatology of the Carolinas, PLLC
🇺🇸Charlotte, North Carolina, United States
Cincinnati Rheumatic Disease Study Group
🇺🇸Cincinnati, Ohio, United States
East Penn Rheumatology Associates
🇺🇸Bethlehem, Pennsylvania, United States
Clinical Research Center of Reading,LLC
🇺🇸Wyomissing, Pennsylvania, United States
Eagle Medical
🇺🇸Crossville, Tennessee, United States
Articularis Healthcare d/b/a/ Low Country Rheumatology, PA
🇺🇸Summerville, South Carolina, United States
Amarillo Center for Clinical Research
🇺🇸Amarillo, Texas, United States
Accurate Clinical Management
🇺🇸Baytown, Texas, United States
Dr. Dhiman Basu Private Practice
🇺🇸Colleyville, Texas, United States
Precision Comprehensive Clinical Research Solutions
🇺🇸Fort Worth, Texas, United States
Accurate Clinical Research
🇺🇸Houston, Texas, United States
Southwest Rheumatology, P.A.
🇺🇸Mesquite, Texas, United States
Advanced Rheumatology of Houston
🇺🇸The Woodlands, Texas, United States
Framingham Centro Medico
🇦🇷La Plata, Buenos Aires, Argentina
Instituto de Investigaciones Clinicas Quilmes
🇦🇷Quilmes, Buenos Aires, Argentina
Clinica Adventista Belgrano
🇦🇷Caba, Ciudad Autónoma De Buenos Aire, Argentina
Sanatorio Británico
🇦🇷Rosario, Santa Fe, Argentina
Centro de Educación Médica e Investigaciones Clínicas "Norberto Quirno" (CEMIC)
🇦🇷Buenos Aires, Argentina
IR Medical Center S.A. Instituto de Reumatologia
🇦🇷Mendoza, Argentina
Optimus Clinical Research
🇦🇺Botany, New South Wales, Australia
Centro de Investigaciones Médicas Tucuman
🇦🇷Tucumán, Argentina
The Rheumatology Research Unit Sunshine Coast
🇦🇺Maroochydore, Queensland, Australia
Emeritus Research
🇦🇺Camberwell, Victoria, Australia
St. Vincent's Hospital
🇦🇺Fitzroy, Victoria, Australia
A O Krankenhaus der Elisabethinen
🇦🇹Linz, Oberösterreich, Austria
Medizinische Universität Graz
🇦🇹Graz, Austria
UZ Leuven
🇧🇪Leuven, Vlaams Brabant, Belgium
Cliniques Universitaires Saint-Luc
🇧🇪Brussels, Belgium
Santa Casa de Misericordia de Belo Horizonte
🇧🇷Belo Horizonte, MG, Brazil
EDUMED - Educação em Saúde Ltda.
🇧🇷Curitiba, Paraná, Brazil
Centro de Estudos em Terapias Inovadoras-CETI
🇧🇷Curitiba, Paraná, Brazil
Oncovida- Centro de Onco-Hematologia de Mato Grosso
🇧🇷Cuiaba, Brazil
Enroll SpA
🇨🇱Providencia, Región Metropolitana De Santia, Chile
Hospital de Clinicas UNICAMP
🇧🇷Campinas, SP, Brazil
Clinical Research Chile SpA
🇨🇱Valdivia, Los Ríos, Chile
Clinica Alemana de Osorno
🇨🇱Osorno, Chile
Sociedad Medica Del Aparato Locomotor SA
🇨🇱Santiago, Chile
Prosalud y cia. Ltda.
🇨🇱Santiago, Chile
CINVEC- Estudos Clínicos Quinta Región Limitada
🇨🇱Vina del Mar, Chile
Peking University First Hospital
🇨🇳Beijing, China
Shanghai Huashan Hospital Affil to Fu Dan University
🇨🇳Shanghai, China
HPTU-El Hospital con alma Pablo Tobon Uribe
🇨🇴Medellin, Antioquia, Colombia
Clinica de la Costa
🇨🇴Barranquilla, Atlantico, Colombia
Circaribe SAS
🇨🇴Barranquilla, Atlántico, Colombia
Idearg S.A.S.
🇨🇴Bogota, Cundinamarca, Colombia
Centro de Medicina Interna
🇨🇴Cali, Valle Del Cauca, Colombia
Servimed S.A.S.
🇨🇴Bucaramanga, Santander, Colombia
Preventive Care Ltdac
🇨🇴Chia, Colombia
Klinicki Bolnicki Centar Rijeka
🇭🇷Rijeka, Croatia
University Hospital Split
🇭🇷Split, Croatia
Revmatologicky ustav
🇨🇿Praha 2, Praha, Hlavní Mešto, Czechia
Revmatologie.s.r.o.
🇨🇿Brno, Czechia
Fakultni nemocnice Olomouc
🇨🇿Olomouc, Czechia
VFN a 1 LF University Karlovy
🇨🇿Praha 2, Czechia
Centre hospitalier universitaire Pellegrin
🇫🇷Bordeaux, France
ARTHROHELP s.r.o.
🇨🇿Pardubice, Czechia
CHRU Brest - Hopital Cavale Blanche
🇫🇷Brest Cedex, Finistère, France
CHRU Lille - Hopital Claude Huriez
🇫🇷Lille Cedex, France
Hôpital de HautePierre
🇫🇷Strasbourg, France
Universitätsklinikum Freiburg
🇩🇪Freiburg, Baden-Württemberg, Germany
Klinikum der Universität München Großhadern
🇩🇪München, Bayern, Germany
Universitätsklinikum Tübingen
🇩🇪Tübingen, Baden-Württemberg, Germany
Universitätsklinikum Würzburg A. ö. R.
🇩🇪Würzburg, Bayern, Germany
Universitätsmedizin Johannes Gutenberg Universität Mainz
🇩🇪Mainz, Rheinland-Pfalz, Germany
Universitätsklinikum Carl Gustav Carus
🇩🇪Dresden, Sachsen, Germany
Krishna Institute of Medical Science
🇮🇳Secunderabad, Telengana, India
Sheba Medical Center
🇮🇱Ramat Gan, Israel
Azienda Ospedaliera Universitaria Pisana
🇮🇹Pisa, Italy
Hokkaido University Hospital
🇯🇵Sapporo, Hokkaido, Japan
Seirei Hamamatsu General Hospital
🇯🇵Hamamatsu, Shizuoka, Japan
Juntendo University Hospital
🇯🇵Bunkyo-ku, Tokyo, Japan
Hamanomachi Hospital
🇯🇵Fukuoka, Japan
Seoul National University Bundang Hospital
🇰🇷Seongnam-si, Gyeonggi-do, Korea, Republic of
Chungnam National University Hospital
🇰🇷Daejeon, Korea, Korea, Republic of
Gabinet Internistyczno- Reumatologiczny Piotr Adrian Klimiuk
🇵🇱Bialystok, Podlaskie, Poland
Winelands Medical Research Centre
🇿🇦Stellenbosch, Western Cape, South Africa
Hospital De Fuenlabrada
🇪🇸Fuenlabrada, Madrid, Spain
Hospital do Meixoeiro
🇪🇸Vigo, Pontevedra, Spain
Hospital Quiron Infanta Luisa
🇪🇸Sevilla, Spain
Corporació Sanitària Clínic
🇪🇸Barcelona, Spain
St George's Hospital
🇬🇧Tooting, London, United Kingdom
Leeds Teaching Hospital
🇬🇧Leeds, United Kingdom
First affiliated Hospital of Sun Yat-Sen University
🇨🇳Guangzhou, Guangdong, China
First Affiliated Hospital of the Harbin Medical University
🇨🇳Harbin, Heilongjiang, China
Pingxiang People's Hospital
🇨🇳Pingxiang, Jiangxi, China
Wuhan Union Hospital
🇨🇳Wuhan, Hubei, China
Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School
🇨🇳Nanjing, Jiangsu, China
China-Japan Union Hospital, CJUH.
🇨🇳Changchun, Jilin, China
Tianjin Medical University General Hospital
🇨🇳Tianjin, Tianjin, China
People's Hospital of Xinjiang Uygur Autonomous Region
🇨🇳Urumqi, Xinjiang, China
Zhongshan Hospital, Fudan University
🇨🇳Shanghai, Shanghai, China
The Second Affiliated Hospital of Zhejiang University School of Medicine
🇨🇳Hangzhou, Zhejiang, China
Ningbo First Hospital
🇨🇳Ningbo, Zhejiang, China
Beijing Peking Union Medical College Hospital
🇨🇳Beijing, China
China Medical University (CMU) - First Affiliated Hospital
🇨🇳Shenyang, China
The First Affliated Hospital of Suzhou University
🇨🇳Suzhou Shi, China
The First Affiliated Hospital of Zhengzhou Universtiy
🇨🇳Zhengzhou, China
Cemdeicy S.C.P.
🇲🇽Merida, Yucatán, Mexico
Centro Peninsular de Investigacion S.C.P
🇲🇽Merida, Yucatán, Mexico
SER - Serviços Especializados em Reumatologia da Bahia S/S - ME
🇧🇷Salvador, Bahia, Brazil
LMK Serviços Médicos S/S
🇧🇷Porto Alegre, Rio Grande Do Sul, Brazil
Maidstone Hospital
🇬🇧Maidstone, Kent, United Kingdom
Fortis Escorts Hospital
🇮🇳Jaipur, Rajasthan, India
Aprillus Asistencia e Investigacion de Arcis Salud SRL
🇦🇷Ciudad Autónoma de Buenos Aire, Buenos Aires, Argentina
Piedmont Healthcare
🇺🇸Atlanta, Georgia, United States
West Tennessee Research Institute
🇺🇸Jackson, Tennessee, United States
Arizona Arthritis & Rheumatology Associates, P. C.
🇺🇸Tucson, Arizona, United States
Glacir View Research Institute
🇺🇸Kalispell, Montana, United States
DOM Centro de Reumatologia
🇦🇷Ciudad de Buenos Aires, Buenos Aires, Argentina
CER Instituto Medico
🇦🇷Quilmes, Buenos Aires, Argentina
Békés Megyei Központi Kórház Pándy Kálmán Tagkórház
🇭🇺Gyula, Békés, Hungary
Budai Irgalmasrendi Korhaz
🇭🇺Budapest, Hungary
Gen Hospital of Athens G Gennimatas
🇬🇷Athens, Attiki, Greece
Kianous Stavros
🇬🇷Thessaloniki, Greece
Regional General University Hospital of Larissa
🇬🇷Larissa, Greece
Vital Medical Center
🇭🇺Veszprem, Veszprém City, Hungary
Debreceni Egyetem Orvos-es Egészsegtudomanyi Centrum
🇭🇺Debrecen, Hungary
Pecsi Tudomanyegyetem Klinikai Kozpont
🇭🇺Pecs, Hungary
CIMS Hospital Private Limited
🇮🇳Ahmedabad, Gujarat, India
Del-pesti Centrumkorhaz - Orszagos Hematologiai es Infektologiai Intezet
🇭🇺Budapest, Hungary
Panchshil hospital
🇮🇳Ahmedabad, Gujarat, India
St. John Medical College & Hospital
🇮🇳Bangalore, Karnataka, India
Sushruta Multispecialty Hospital & Research Center Pvt Ltd
🇮🇳Hubli, Karnataka, India
Meir Medical Center
🇮🇱Kfar Saba, Israel
Nirmal Hospital Private Limited
🇮🇳Surat, Gujarat, India
Synexus Affiliate - Sujata Birla Hospital & Medical Research Center
🇮🇳Nashik, Maharashtra, India
Szegedi Tudomanyegyetem Szent-Gyorgyi Albert Klinikai Kozpont I. Belgyogyaszati Klinika
🇭🇺Szeged, Hungary
Vita Verum Egeszsegugyi Szolgaltato Bt
🇭🇺Székesfehérvár, Hungary
ChanRe Rheumatology And Immunology Center And Research
🇮🇳Bangalore, Karnataka, India
Sterling Hospital
🇮🇳Vadodara, Gujarat, India
Kasturba Medical College Hospital, Mangalore
🇮🇳Madhav Nagar, Manipal, Karnataka, India
Shree Giriraj Hospital
🇮🇳Rajkot, Gujarat, India
Carmel Hospital
🇮🇱Haifa, Ḥeifā, Israel
Jasleen Hospital
🇮🇳Nagpur, Maharashtra, India
University of Occupational and Enviromental Health
🇯🇵Kitakyushu, Fukuoka, Japan
St. Luke's International Hospital
🇯🇵Tokyo, Japan
National Hospital Organization Asahikawa Medical Center
🇯🇵Asahikawa, Hokkaido, Japan
Kobe University Hospital
🇯🇵Kobe, Hyogo, Japan
Hiroshima University Hospital
🇯🇵Hiroshima, Japan
Tomishiro Central Hospital
🇯🇵Tomigusuku, Okinawa, Japan
Jp Red Cross Society Himeji Hp
🇯🇵Himeji, Hyogo, Japan
Kagawa University Hospital
🇯🇵Kita-gun, Kagawa, Japan
Keio university hospital
🇯🇵Tokyo, Japan
Tohoku University Hospital
🇯🇵Sendai-shi, Miyagi, Japan
Nippon Medical School Hospital
🇯🇵Bunkyo-Ku, Tokyo, Japan
National Hospital Organization Kyushu Medical Center
🇯🇵Fukuoka, Japan
Consultorio Jose Luis Garcia Figueroa
🇲🇽Villahermosa, Tabasco, Mexico
Dr. Alberto Esteban Bazzoni Ruiz
🇲🇽Torreon, Coahuila, Mexico
Clinosar Mexico S.A. de C.V
🇲🇽Mexico City, Mexico
Centro Integral en Reumatologia SA de CV
🇲🇽Guadalajara, Jalisco, Mexico
Clinica de Investigacion en Reumatologia y Obesidad S. C.
🇲🇽Guadalajara, Jalisco, Mexico
Medische Centrum Leeuwarden
🇳🇱Leeuwarden, Fryslân, Netherlands
Investigación Biomédica para el Desarrollo de Fármacos S.A. de C.V.
🇲🇽Zapopan, Jalisco, Mexico
Centro de Alta Especialidad Reumatologia Inv del Potosi SC
🇲🇽San Luis Potosi, SLP, Mexico
Consultorio de Reumatologia
🇲🇽Mexico City, Mexico
Chong Hua Hospital
🇵🇭Cebu City, Cebu, Philippines
Centro de Estudios de Investigacion Metabolicos y Cardiovasculares
🇲🇽Guadalajara, Jalisco, Mexico
Köhler & Milstein Research
🇲🇽Merida, Yucatan, Mexico
Centro de Investigación y Tratamiento Reumatológico S.C
🇲🇽Ciudad De México, Mexico
Oaxaca Site Management Organization
🇲🇽Oaxaca, Mexico
Vrije Universiteit Medisch Centrum Amsterdam
🇳🇱Amsterdam, Netherlands
Klinika Reumatologii, Chorob Wewnetrznych i Geriatrii PUM
🇵🇱Szczecin, Poland
Cebu Doctors Hospital
🇵🇭Cebu City, Cebu, Philippines
Makati Medical Center
🇵🇭Makati, Luzon, Philippines
Szpital Uniwersytecki Nr 2 im. dr J. Biziela w Bydgoszczy, Klinika Reumatologii i Chorob Tkanki Lacznej
🇵🇱Bydgoszcz, Kujawsko-pomorskie, Poland
Reumatika - Centrum Reumatologii
🇵🇱Warszawa, Mazowieckie, Poland
Southern Philippines Medical Center
🇵🇭Davao, Davao Del Norte, Philippines
St. Luke's Medical Center
🇵🇭Quezon City, Luzon, Philippines
Angeles University Foundation and Medical Center
🇵🇭Angeles City, Pampanga, Philippines
Twoja Przychodnia Centrum Medyczne Nowa Sol
🇵🇱Nowa Sol, Lubuskie, Poland
Napoca Emergency Clinical County Hospital
🇷🇴Napoca, Cluj, Romania
Niepubliczny Zaklad Opieki Zdrowotnej Biogenes Sp. z o.o.
🇵🇱Wroclaw, Dolnoslaskie, Poland
Medycyna Kliniczna
🇵🇱Warszawa, Mazowieckie, Poland
Centrum Medyczne Pratia Katowice
🇵🇱Katowice, Poland
Klinika Reumatologii i Rehabilitacji
🇵🇱Poznan, Poland
Chelyabinsk Regional Clinical Hospital
🇷🇺Chelyabinsk, Russian Federation
Centrum Medyczne AMED
🇵🇱Warszawa, Poland
Spitalul Clinic "Dr. Ioan Cantacuzino"
🇷🇴Bucuresti, Romania
Orenburg State Medical Academy of Roszdrav
🇷🇺Orenburg, Russian Federation
Ambulatorium Barbara Bazela
🇵🇱Elblag, Warminsko-Mazurki, Poland
Centrum Medyczne Plejady
🇵🇱Krakow, Poland
Craiova Emergency Clinical County Hospital
🇷🇴Craiova, Dolj, Romania
Spitalul Clinic Sf Maria Bucuresti
🇷🇴Bucuresti, Romania
MCM Krakow - PRATIA - PPDS
🇵🇱Krakow, Poland
NZOZ Lecznica MAK-MED s.c.
🇵🇱Nadarzyn, Poland
V.A. Nasonova Research Institute of Rheumatology
🇷🇺Moscow, Russian Federation
C.M.D.T.A. Neomed
🇷🇴Brasov, Brașov, Romania
Spitalul Euroclinic
🇷🇴Bucureti, București, Romania
SANA Medical Center
🇷🇴Bucharest, Romania
Moscow City Clinical Hospital Number 52
🇷🇺Moscow, Moskva, Russian Federation
LLC MK Med
🇷🇺St. Petersburg, Saint Petersburg, Russian Federation
Institute of Cytology and Genetics of Siberian Branch of Russian Academy of Medical Sciences
🇷🇺Novosibirsk, Russian Federation
Kursk Regional Clinical Hospital
🇷🇺Rursk, Russian Federation
Russian National Research Medical University n.a. N.I.Pirogov
🇷🇺Moscow, Russian Federation
City Hospital # 7
🇷🇺Kazan, Russian Federation
Research Institute of Clinical Immunology
🇷🇺Novosibirsk, Russian Federation
Regional Hospital - Omsk
🇷🇺Omsk, Russian Federation
Military Medical Academy
🇷🇸Belgrade, Serbia
Hospital Marina Baixa
🇪🇸La Vila Joiosa, Alicante, Spain
Kuvatov Republican Clinical Hospital
🇷🇺Ufa, Russian Federation
Institute for Treatment and Rehabilitation Niska Banja
🇷🇸Niska Banja, Serbia
Ryazan State Medical University
🇷🇺Ryazan, Russian Federation
Departmental Hospital at Smolensk Station "rzhd" JSC
🇷🇺Smolensk, Russian Federation
Russian Medical Military Academy n.a. S.M. Kirov
🇷🇺Saint Petersburg, Russian Federation
LLC Medical Center Zdorovaya Semiya
🇷🇺Zonova, Russian Federation
Vincent Pallotti Hospital
🇿🇦Cape Town, Western Cape, South Africa
Panorama Medical Centre
🇿🇦Cape Town, Western Cape, South Africa
Institute of Rheumatology
🇷🇸Belgrade, Serbia
University Clinical Center of Serbia
🇷🇸Belgrade, Serbia
Kaohsiung Veterans General Hospital
🇨🇳Kaohsiung, Taiwan
China Medical University Hospital
🇨🇳Taichung, Taiwan
Clinical Center of Vojvodina
🇷🇸Novi Sad, Serbia
Chang Gung Memorial Hospital - Linkou
🇨🇳Taoyuan City, Taiwan
Chang Gung Memorial Hospital - Kaohsiung Branch
🇨🇳Kaohsiung, Taiwan
Corporacion Sanitaria Parc Tauli
🇪🇸Sabadell, Barcelona, Spain
Taichung Veterans General Hospital
🇨🇳Taichung, Taiwan
Guys/St. Thomas Hospital
🇬🇧London, Surrey, United Kingdom
National Taiwan University Hospital
🇨🇳Taipei, Taiwan
Taipei Medical University Hospital
🇨🇳Taipei, Taiwan
Hopital Européen
🇫🇷Marseille, France
Henry Ford Health System
🇺🇸Detroit, Michigan, United States
Achieve Clinical Research, LLC
🇺🇸Birmingham, Alabama, United States
Arizona Arthritis & Rheumatology Research
🇺🇸Phoenix, Arizona, United States
Denver Arthritis Clinic - Lowry
🇺🇸Denver, Colorado, United States
Arthritis & Rheumatology Center of Oklahoma PLLC
🇺🇸Oklahoma City, Oklahoma, United States
Oklahoma Medical Research Foundation
🇺🇸Oklahoma City, Oklahoma, United States
Accurate Clinical Research, Inc.
🇺🇸San Antonio, Texas, United States
ForCare Clinical Research
🇺🇸Tampa, Florida, United States
Tampa Medical Group, P.A.
🇺🇸Tampa, Florida, United States
Arthritis Center of Lexington
🇺🇸Lexington, Kentucky, United States
Inland Rheumatology & Osteoporosis Medical Group
🇺🇸Upland, California, United States
Schlosspark Klinik
🇩🇪Berlin, Germany
City Clinical Hospital 1 named after N.I. Pirogov
🇷🇺Moscow, Russian Federation