Subclinical Diabetes Confirmed by 75gm-OGTT Influence on the Prognosis of Decompensated Cirrhosis
- Conditions
- Liver Cirrhosis
- Registration Number
- NCT04828512
- Lead Sponsor
- Yonsei University
- Brief Summary
Disorders of glucose metabolism, such as impaired glucose intolerance (IGT) and diabetes mellitus (DM), frequently occur in cirrhosis. However, it has been underestimated when fasting plasma glucose (FPG) levels are considered. We aimed to evaluate who needs to be undertaken a 75-g oral glucose tolerance test (OGTT) to find underlying subclinical diabetes.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 1015
Inclusion Criteria
- Liver cirrhosis
- Admitted to a hospital
Exclusion Criteria
- Previously confirmed DM
- Being treated for DM
- Standard risk factors of T2DM, such as high body mass index and family history of diabetes
- Symptoms of DM, such as increased thirst and the need to urinate
- Either hepatocellular carcinoma or other malignancy
- Hepatic failure or uncontrolled decompensation [that is, refractory ascites or active variceal hemorrhage]
- Significant illnesses such as sepsis that may have interfered with glucose metabolism
- Pancreatic dysfunction such as acute/chronic pancreatitis that may have affected glucose metabolism.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Survival through study completion, an average of 3 year Overall survival
- Secondary Outcome Measures
Name Time Method major complications of cirrhosis through study completion, an average of 3 year hepatic encephalopathy (HE), the development of spontaneous bacterial peritonitis (SBP), acute kidney injury (AKI), variceal bleeding, and infection