跳至主要内容
临床试验/NCT05459337
NCT05459337进行中(未招募)不适用

Multidisciplinary Support to Access Living Donor Kidney Transplant (MuST AKT)

University of Alberta1 个研究点 分布在 1 个国家目标入组 66 人开始时间: 2022年10月18日最近更新:
适应症

试验速览

阶段
不适用
状态
进行中(未招募)
入组人数
66
试验地点
1
主要终点
Living Kidney Donor Transplantation

研究概览

简要总结

For people living with kidney failure, the two active treatment options are dialysis or kidney transplantation. Transplantation is optimal, and especially from a living donor - offering patients longer survival, a better quality of life, and cost savings for the health system when compared to dialysis. However, 20% of patients die on dialysis while waiting for a deceased donor organ. As the rate of kidney failure continues to rise, the gap between demand and supply of the organs for transplantation increases.

Compared to other provinces in Canada, the rate of living kidney donor transplantation is lower in Alberta, so it is essential that improvements are made to the process around living kidney donor transplantation, for better patient outcomes and care.

Our published evidence-based review on strategies to increase living kidney donation, found that for patients with kidney failure, the intervention with the greatest health impact was personalized support, provided by a multidisciplinary team, to inform and educate the patients' social network. A province-wide survey also confirmed that many patients with kidney failure are unable to find a living kidney donor and also find it difficult to approach potential donors due to lack of skills, supports, and resources.

The investigators have developed the Multidisciplinary Support To Access living donor Kidney Transplant (MuST AKT) intervention to support potential kidney transplant recipients find living donors through their social networks, and thereby increase the number of living kidney donor transplants in Alberta. The investigators will test the effectiveness of this intervention.

详细描述

Living donor kidney transplantation (LDKT) is the optimal treatment for end-stage kidney disease patients, offering patients longer survival, a better quality of life, and cost savings for the health system when compared to dialysis. Outcome data shows that only 16% of Canadians on dialysis survive past 10 years, whereas up to 74% of Canadians with a kidney transplant have a functioning kidney after 10 years. The ideal treatment trajectory is to avoid dialysis entirely and receive a living donor transplant prior to dialysis (pre-emptive), which unfortunately only occurs in 10.5% of eligible patients.

Patients with kidney failure report barriers to LDKT, including navigating the system, addressing their concerns and fears, identifying and approaching potential living donors, keeping motivated, and then utilizing the ones unable to donate as advocates. To address these barriers and increase LDKT, the MuST AKT intervention has been developed. MuST AKT is designed to provide personalized support and enable potential kidney transplant recipients to communicate their story and desire for a LDKT with their personal and broader social networks.

A definitive Randomized Controlled Trial is proposed to test the effectiveness of the MuST AKT intervention to increase LDKT outcomes in a larger sample, before scaling to and implementing across Alberta.

Primary Objective:

The primary objective of this study is to examine the effectiveness of the MuST AKT intervention to increase living donor kidney transplantation outcomes.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Other
盲法
Single (Investigator)

入排标准

年龄范围
18 Years 至 75 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • English speaking
  • No obvious contraindication to kidney transplantation
  • Successfully completed 'introduction to kidney transplant' module

排除标准

  • Potential Living Kidney Donor identified
  • Previously received organ transplant
  • Candidate for multi-organ transplant
  • Stanford Integrated Psychosocial Assessment for Transplant (SIPAT) Score >20
  • Rapid Estimate of Adult Literacy in Medicine (REALM-66) score <19(illiterate in English)

结局指标

主要结局

Living Kidney Donor Transplantation

时间窗: 24 months

Proportion of participants undergoing living kidney donor transplantations

次要结局

  • Living Kidney Donor Evaluation Approved(12 months)
  • Living Kidney Donor Evaluation Started(12 months)
  • Contact Living Donor Services(12 months)

研究者

申办方类型
Other
责任方
Sponsor

研究点 (1)

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