Evaluating the effect of low-level laser versus ozone in patients with Medication-related osteonecrosis of the jaw who were treated with debridement surgery and Platelet-rich fibri

Phase 3

• Conditions: Condition 1: Osteonecrosis. Condition 2: Pain in jaw. Condition 3: Soft tissue dehiscence.; Osteonecrosis due to drugs; Disease of jaws, unspecified; Soft tissue disorder, unspecified; M87.1; K10.9; M79.9

• Registration Number: IRCT20150613022697N13
• Lead Sponsor: Mashhad University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 13 March 2023

Recruitment & Eligibility

• Status: Pending
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

All patients with Medication-related osteonecrosis of the jaw, MRONJ stage 2, with pain and pus discharge
No history of previous MRONJ treatment
Absence of pathological fracture during study entry

Exclusion Criteria

Pregnant patients
The impossibility of frequent visits for complementary treatment sessions (ozone or laser)
Radiotherapy during the treatment process
Occurrence of pathological fracture in the jaw in the affected area
Dissatisfaction with continuing the study

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Amount of jaw pain in the specified time period. Timepoint: 1, 3, 6 and 12 months after the intervention. Method of measurement: Visual Analogue Scale (VAS) in checklist.;Soft tissue healing. Timepoint: 1, 3, 6 and 12 months after the intervention. Method of measurement: Appropriate soft tissue healing was defined when no dehiscence occurred.

Secondary Outcome Measures

Name	Time	Method
Infection. Timepoint: 1, 3, 6 and 12 months after the intervention. Method of measurement: Any sign of pus or fistula tract in treatment area.