Exploring the Relationship Between Varying CO2 Levels and the Regional BOLD Signal, by Using Breathing Exercises
- Conditions
- Healthy
- Registration Number
- NCT00660465
- Lead Sponsor
- Soroka University Medical Center
- Brief Summary
The purpose of this study is to explore how arterial PaCO2 effect regional Blood Oxygen Level Dependent (BOLD) signal, and indirectly the brain regional O2 level .
- Detailed Description
Among many parameters effecting cerebral blood flow(CBF), partial pressure of CO2 (PaCO2) in arterial blood has a significant effect. A small increase in arterial PaCO2 level will cause a significant increase of CBF , followed by increase of O2 level . The main objective is to explore the effect of arterial PaCO2 level on regional CBF and brain O2 level, by using breathing exercises to modulate arterial PaCO2. The regional Blood Oxygen Level Dependent (BOLD) signal produced by MRI , will indicate the regional O2 level.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 6
- adults over 18 years old .
- under 18 years old.
- Artificial pacemaker
- implantable cardioverter-defibrillator (ICD)
- Hearing aid, implantable or portable.
- artificial heart valve
- Surgical clips
- Metal fragments in eyes
- Electronic stimulators
- Implanted pumps
- Implantable Neurostimulation Device
- metal fragments of any sort
- Permanent makeup or tattoo
- transfusion pump
- pregnant or breast feeding women
- False teeth , retainer or dental crown
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Department of Diagnostic Imaging ;Soroka Univrsity Medical Center
🇮🇱Beer Sheva, Israel