Prospective Studies of the Pathogenesis of Schizophrenia
Completed
- Conditions
- Schizophrenia
- Registration Number
- NCT00877552
- Lead Sponsor
- University of North Carolina, Chapel Hill
- Brief Summary
The purpose of this study is to use structural and functional magnetic resonance imaging (MRI) to study children at high risk for schizophrenia. It is hypothesized that children at high risk for schizophrenia will have abnormalities of brain development, especially of the cerebral cortex. The study will also describe normal brain development in children from birth to age 6 years
- Detailed Description
We are currently following enrolled children at 4 and 6 years of age. We are obtaining structural MRIs and rsfMRIs. In addition, we are assessing cognitive function and behavior with Stanford-Binet, BRIEF and BASC.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 598
Inclusion Criteria
- control, offspring of mother with schizophrenia or bipolar illness; child with MVM
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Exclusion Criteria
- major neurological or medical illness
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Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method magnetic resonance images (structural and functional) birth, ages 1, 2 , 4 and 6 years
- Secondary Outcome Measures
Name Time Method Cognitive development 0,1,2,4 and 6 years
Trial Locations
- Locations (1)
UNC Department of Psychiatry
🇺🇸Chapel Hill, North Carolina, United States