ISRCTN19064955已完成未知
Effects of dietary nitrate supplementation on muscular strength and oxygen cost during submaximal exercise in older subjects
The Centre for Integrated Research into Musculoskeletal Ageing (UK)0 个研究点目标入组 20 人开始时间: 2013年12月16日最近更新:
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 发起方
- 入组人数
- 20
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 性别
- All
入选标准
- •1. Non-smoking men and women aged between 60 and 75 years of age
- •2. English speakers and with a body mass index (BMI) of between 18.5 and 29.9 kg/m2. We have stated that participants must be English speakers because we cannot offer translation services for this study.
排除标准
- •1. Current participation in other research clinical studies
- •2. Very high resting blood pressure readings (systolic >180 mmHg and/or diastolic >110 mmHg)
- •3. Vegetarianism (likely to have very high nitrate intake)
- •4. High physical activity level (>15,000 steps per day; may have BMI in overweight range but low fat mass)
- •5. Weight change more than 3.0 kg in the last 2 months (important influence on systemic metabolism and vascular function)
- •6. Active cancer and any diagnosis of malignant cancer in the last 5 years (systemic effects on study outcomes)
- •7. Diagnosis of chronic and acute metabolic and inflammatory conditions interfering with the study outcome (systemic effects on study outcomes). For example flu, Crohn's disease, rheumatoid arthritis
- •8. Weight loss medications (sibutramine, orlistat, rimonabant) and history of bariatric surgery (weight loss related changes in systemic metabolism)
- •9. Previous diagnosis of type 1 or type 2 diabetes treated with insulin and oral hypoglycaemic agents (modification of regulation of intermediate metabolism). Type 2 diabetic patients treated with diet only will be included in the study.
- •10. Drugs: corticosteroids, sildenafil, aspirin, NSAIDs, diuretics, beta-blockers, antacids, anti-hypertensive (Ca++ channel blockers, ACE inhibitors), statins and any other anti-dyslipidaemic agent, anticoagulants, nitrate-derived agents, anti-cholinergic (all drugs may have an effect on NO production via different mechanisms)
- •11. Subjects on hormonal therapies (oestrogens, thyroxine, progesteron) and psychiatric drugs (antidepressants, sedatives, antipsychotics) will be excluded if dose has been started/changed in the previous three months (make sure that these disorders are under strict control to avoid interference with the study outcomes)
- •12. Haematological disorders including self-reported anaemia (risk for the participant and effects on the study outcomes)
- •13. Major surgical operations interfering with the study outcomes (systemic effects on study outcomes)
- •14. Alcohol intake >21 units/week for men and >14 units/week for women
- •15. Blood donations in the previous 3 months
研究者
相似试验
招募中
不适用
The impact of dietary nitrate ingestion on muscle protein synthesis in elderly type II diabeticsspiermassametabolismeadult onset diabetesType 2 diabetes10018424NL-OMON37520niversiteit Maastricht32
招募中
不适用
itrate and muscle performanceNL-OMON27128HAN University of Applied Sciences15
招募中
不适用
The effects of beet and grape juice consumption and exercise on blood pressure and glycemia in patients with excess weight and high glycemiaObesity, blood pressure, oxidative stress, exercise, metabolismG03.495C18.654.726.500G09.330.380.076.347G03.495.710G11.427.590.530.698.277RBR-5gkhhjAna Paula Trussardi Fayh
已完成
不适用
The Effect of Dietary Nitrate Supplementation on Linear Running Sprint Performance, Agility and Vertical Jump Performance in a Rested and Fatigued StateExercise PerformanceNCT03565523PepsiCo Global R&D32
招募中
Unknown
Effect of beetroot juice ingestion on strengthRBR-3b557kxniversidade de São Paulo