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Clinical Trials/NCT04747587
NCT04747587
Completed
Not Applicable

Non-use après Accident Vasculaire cérébral : Influence de la Force et de la précision du Geste à Fournir Lors Des Mouvements du Membre supérieur parétique

Centre Hospitalier Universitaire de Nīmes2 sites in 1 country53 target enrollmentMay 11, 2021
ConditionsStroke

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Stroke
Sponsor
Centre Hospitalier Universitaire de Nīmes
Enrollment
53
Locations
2
Primary Endpoint
Evaluate the modifications of the proximal non-use after stroke on the paretic side according to the extent of force constraint
Status
Completed
Last Updated
4 months ago

Overview

Brief Summary

After a stroke, 80% of patients have an upper limb deficit, limiting activity. Some develop a non-use: they can, but do not, use their paretic limb. Non-use is a general phenomenon applied to all situations where the patient applies unnecessary compensation. Several rehabilitation techniques are effective to counter non-use, but there is insufficient knowledge to choose the most suitable technique. Optimal control theory could help guide these choices. It assumes that the chosen coordination satisfies the constraints of the task (force, amplitude, tolerance) while reducing the cost of the movement. This study will assess non-use by anticipating the sensitivity to the constraints of force and precision deduced from the logic of optimal control. The study authors expect to observe a weakness effect: in a reaching task (i.e. when the person has to touch an object placed in front of them), lightening the paretic arm makes it possible to reduce non-use, and a precision effect: in a reaching task, non-use increases with the required spatial precision.

Registry
clinicaltrials.gov
Start Date
May 11, 2021
End Date
April 25, 2023
Last Updated
4 months ago
Study Type
Interventional
Study Design
Parallel
Sex
All

Investigators

Sponsor
Centre Hospitalier Universitaire de Nīmes
Responsible Party
Sponsor

Eligibility Criteria

Inclusion Criteria

  • Inclusion criteria specific to the stroke group:
  • Patient having had a 1st stroke
  • Patient whose stroke occurred more than a month ago.
  • Patient having had a supratentorial stroke
  • Patient able to touch the opposite knee with the paretic arm
  • Inclusion criteria specific to the control group:
  • Subject who has never had a stroke
  • Subject without motor or orthopedic impairment of the upper limbs and in particular of the shoulder
  • General inclusion criteria:
  • Subject who has given free and informed consent.

Exclusion Criteria

  • Not provided

Outcomes

Primary Outcomes

Evaluate the modifications of the proximal non-use after stroke on the paretic side according to the extent of force constraint

Time Frame: Inclusion

Proximal Arm Non Use (PANU) score (%): A significant PANU (\> 7.5%) indicates non-use

Secondary Outcomes

  • Evaluate the modifications of the proximal non-use in the control subjects according to the constraints of force or precision(Inclusion)
  • Intensity of arm deficit(Inclusion)
  • height of the target(Inclusion)
  • Model the constraints and costs explaining non-use patient by patient, to distinguish between physiological and psycho-behavioral non-use(Inclusion)
  • Evaluate the level of neuromuscular activation during reaching(Inclusion)
  • Time since stroke (acute, subacute or chronic phase)(Inclusion)
  • Evaluate the modifications of the proximal non-use after stroke on the paretic side according to the precision required(Inclusion)

Study Sites (2)

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