Correlation of Genetic Polymorphisms and Clinical Parameters With the Complexity of Coronary Artery Disease in the Greek Population
试验速览
- 阶段
- 不适用
- 入组人数
- 270
- 试验地点
- 1
- 主要终点
- Relationship between genetic risk variants and the SYNTAX score [All-comers population]
研究概览
简要总结
The purpose of the research project is to investigate the potential association of 6 genetic polymorphisms with the complexity and the severity of coronary artery disease (SYNTAX score). The aim of the study is to combine genetic, clinical and laboratory data in order to create a prognostic tool that will enable an individualized therapeutic patient approach.
详细描述
This study focus on the prediction of future risk of cardiovascular events, assessing the severity and complexity of coronary artery disease by incorporating genetic information into the SYNTAX score and providing personalized therapeutic guidance to patients. The ultimate goal of the study would be to identify, design and develop a panel of genetic markers that in combination with clinical and angiographic information will be a reliable tool for predicting cardiovascular risk for future adverse events. Clinical and genetic patient information are systematically collected in a fashion that will enable also retrospective evaluation.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patients who are admitted in the Department of Cardiology in the AHEPA University General Hospital of Thessaloniki and undergo coronary angiography for clinical purposes
- •Patients giving voluntary written consent to participate in the study
- •Male or female patients between 18 years to 90 years at entry
- •Patients without previous history of CAD
排除标准
- •Patients < 18 years old and > 90 years old at time of coronary angiography
- •Patients with a previous history of CAD
- •Cardiac Arrest at admission
- •Patients with serious concurrent disease and life expectancy of < 1 year
- •Patients who refuse to give written consent for participation in the study
结局指标
主要结局
Relationship between genetic risk variants and the SYNTAX score [All-comers population]
时间窗: 12 months
The investigators will evaluate the effects of 6 known genetic variants associated with risk of Coronary Artery Disease on the extend and severity of coronary atherosclerosis \[as assessed by the SYNTAX score\] in patients with significant CAD on coronary angiography, both individually and combined in a Genetic Risk Score
次要结局
- MACCEs(12 months)
- Predictive value of combining a Genetic Risk Score & SYNTAX score for the prediction of 1-year MACCEs(12 months)
- Ankle-Brachial Index(At hospital admission)
- Left Ventricular Ejection Fraction(At hospital admission & 12 months after discharge from hospital)
- Neutrophil to Lymphocyte Ratio(At hospital admission)
- Red Cell Distribution Width(At hospital admission)
- Mean Platelet Volume(At hospital admission)
- High Density Lipoprotein(At hospital admission)
- Glomerular Filtration Rate(At hospital admission)
研究者
Georgios P Rampidis, MD, MSc
Principal Investigator
Aristotle University Of Thessaloniki