ISRCTN15371662
已完成
未知
Effects of high-intensity versus low-intensity praziquantel treatment on HIV disease progression and immunological responses among HIV and Schistosoma mansoni co-infected patients
概览
- 阶段
- 未知
- 干预措施
- 未指定
- 疾病 / 适应症
- HIV, schistosomiasis
- 发起方
- Medical Research Council
- 入组人数
- 363
- 状态
- 已完成
- 最后更新
- 6年前
概览
简要总结
2019 results in https://pubmed.ncbi.nlm.nih.gov/30498791 (added 30/01/2020)
研究者
入排标准
入选标准
- •1\. ART\-naïve HIV\-positive men and women with evidence of co\-infection with S. mansoni
- •2\. Aged 18 years or over
- •3\. Not eligible for ART (CD4 count more than 350 cells/mm3 or not in WHO Stage IV and advanced stage III)
- •4\. Willing to provide a stool sample for testing S. mansoni and other worms and accept treatment with praziquantel and albendazole
- •5\. Willing to provide blood for viral loads, CD4 count and other blood tests
- •6\. Able and willing to provide informed consent (literacy is not required)
- •7\. Willing to undergo HIV testing, counseling and receive HIV test results
- •8\. Available for follow\-up for study duration
- •9\. Able and willing to provide adequate locator information for tracking purposes, and willing to be contacted by the study staff
排除标准
- •1\. Pregnancy or planning to be pregnant during study period
- •2\. Has taken praziquantel in the preceding 3 months
- •3\. Symptomatic helminth infection (haemoglobin less than 8 g/dl, bloody diarrhea, clinically apparent liver disease)
- •4\. Symptomatic complications of S.mansoni (vomiting blood, hepatosplenomegaly)
- •5\. S. mansoni egg count more than 2000/g of stool as evidence points a high egg burden (\>2000 eggs/g) highly associated with periportal fibrosis
结局指标
主要结局
未指定
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