Determining the tissue-penetration of antibiotics into liver cysts.
- Conditions
- In this explorative pharmakinetics study, our aim is to assess tissue-penetration of antibiotics (ciprofloxacin, co-trimoxazole, doxycycline and piperacillin/tazobactam) into hepatic cysts, to guide therapy for hepatic cyst infections.
- Registration Number
- NL-OMON20974
- Lead Sponsor
- Radboud university medical center
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 20
Inclusion Criteria
Age < 18 years
- Indication for aspiration and sclerotherapy (large symptomatic liver cyst)
Exclusion Criteria
- History of hypersensitivity to multiple antibiotics, making it impossible to include the patient in one of two treatment groups.
- Use of other drugs with a contra-indication for antibiotic use, making it impossible to include the patient in one of two treatment groups.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The primary endpoint of the study is the hepatic cyst penetration of ciprofloxacin, co-trimoxazole, doxycycline and piperacillin/tazobactam,defined as the ratio (%) of cyst aspirate concentration (ug/ml) to blood plasma concentration (ug/ml).
- Secondary Outcome Measures
Name Time Method Day-curve plasma concentrations. <br>