Clinical implications of biological markers of orthodontic tooth movement (OTM) using two different aligners
试验速览
- 阶段
- Phase 3 4
- 状态
- 尚未招募
- 发起方
- 入组人数
- 6
- 试验地点
- 1
- 主要终点
- Changes in the level of biomarkers at various time points of the othodontic treatment
研究概览
简要总结
Induction of biologically active compounds occur inside the periodontium during orthodontic tooth movement (OTM). The spatiotemporal events that happen during OTM can be assessed / illustrated by evaluation of these and hence known as biomarkers. Biomarkers are quantifiable criteria of biological processes that provide indications objectively. During the orthodontic procedure, the analysis of saliva and gingival crevicular fluid (GCF) may be examined to monitor biological process/progress. They also have the features of specificity and sensitivity which would correlate objectively with the biological events that occur during OTM. Adequate knowledge about the cellular and biological processes makes it easier to understand the biological mechanics that can shorten the treatment time avoiding the detrimental effects linked to the orthodontic treatment due to its objective characteristics. Does orthodontic forces with the two different aligner systems impact bone remodeling differentially ?
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 盲法
- None
入排标准
- 年龄范围
- 20.00 Year(s) 至 40.00 Year(s)（—）
- 性别
- All
入选标准
- •1.Periodontally healthy adult patients who require orthodontic treatment.
- •2.Those patients who meet the criteria to be treated by aligners in the age group of 20 -40 years.
排除标准
- •1.Patients who have taken any drugs that might alter bone metabolism in the last 6 months.
- •2.Patients with systemic conditions viz.
- •DM, Hypertension etc.
- •and known allergy.
- •3.Pregnant/ lactating women.
结局指标
主要结局
Changes in the level of biomarkers at various time points of the othodontic treatment
时间窗: 7,14,21,28 and 42 DAYS
次要结局
- Changes in the tooth movement at various time points of the orthodontic treatment(7,14,21,28 & 42 DAYS)
研究者
Pooja Lakshmanan
Ragas Dental College and Hospital,