Phase 3 Study of MRTX849 (Adagrasib) vs Docetaxel in Patients With Advanced Non-Small Cell Lung Cancer With KRAS G12C Mutation

Phase 3

Active, not recruiting

• Conditions: Metastatic Non Small Cell Lung Cancer; Advanced Non Small Cell Lung Cancer
• Interventions: Drug: MRTX849; Drug: Docetaxel

• Registration Number: NCT04685135
• Lead Sponsor: Mirati Therapeutics Inc.

Brief Summary

This Phase 3 study will evaluate the efficacy of the investigational agent MRTX849 (adagrasib) versus docetaxel in patients who have been previously treated for metastatic NSCLC with a KRAS G12C mutation.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2020-12-21
• Study First Submitted QC: 2020-12-23
• Study First Posted: 2020-12-28
• Study Start: 2021-04-01
• Primary Completion: 2023-12-30
• Status Verified: 2024-06
• Last Update Submitted: 2024-06-18
• Last Update Posted: 2024-06-21
• Study Completion: 2024-12-31

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: All
• Target Recruitment: 453

Inclusion Criteria

• Histologically or cytologically confirmed diagnosis of NSCLC with KRAS G12C mutation.
• Candidacy to receive treatment with docetaxel.

Crossover Inclusion Criteria:

• Evidence of RECIST 1.1 defined disease progression on docetaxel per BICR
• ECOG performance status 0-2

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Exclusion Criteria

• Prior treatment with an agent targeting KRAS G12C (e.g., AMG 510, Sotorasib).
• Active brain metastases.

Crossover Exclusion Criteria:

• Receipt of any other systemic anti-cancer therapy after last administration of docetaxel on the study.

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
MRTX849	MRTX849	-
Docetaxel	Docetaxel	-

Primary Outcome Measures

Name	Time	Method
Progression-free Survival (PFS)	32 Months	Defined as time from randomization until disease progression or death from any cause, whichever occurs first.

Secondary Outcome Measures

Name	Time	Method
Overall Survival (OS)	49 Months	Defined as time from date of randomization to date of death due to any cause.
Objective Response Rate (ORR)	32 Months	Defined as the percent of patients documented to have a confirmed CR or PR.
Duration of Response (DOR)	49 Months	Defined as the time from date of the first documentation of objective tumor response (CR or PR) to the first documentation of either Progression of Disease (PD) or death due to any cause, whichever occurs first.
1-year Survival Rate	49 Months
Safety	49 Months	characterized by type, incidence, severity, timing, seriousness and relationship to study treatment of AEs, laboratory abnormalities, and number of patients discontinuing study treatment due to an adverse event.
Population PK parameters of MRTX849	49 Months	Data for this Outcome Measure will not be reported here but will be used in a Population PK Analysis which will include participants who were not enrolled in this study, and issued in a separate report. ClinicalTrials.gov is designed for reporting results from only those participants who were enrolled in the study and described in the Participant Flow and Baseline Characteristics modules
Patient Reported Outcomes (PROs)	49 Months	To be assessed by Lung Cancer Symptom Scale (LCSS).
Quality of LIfe Assessment	49 Months	To be assessed by European Quality of Life Five Dimensions Questionnaire (EQ-5D-5L).

Trial Locations

Locations (263)

Holy Cross Health Fort Lauderdale - Holy Cross Hospital; 🇺🇸 Fort Lauderdale, Florida, United States

University of Illinois Hospital & Health Sciences System; 🇺🇸 Chicago, Illinois, United States

New England Cancer Specialists - Scarborough; 🇺🇸 Scarborough, Maine, United States

Ascension Providence Cancer Center - Southfield; 🇺🇸 Southfield, Michigan, United States

NEXT Virginia; 🇺🇸 Fairfax, Virginia, United States

University Hospitals Cleveland Medical Center; 🇺🇸 Cleveland, Ohio, United States

Tulane University; 🇺🇸 New Orleans, Louisiana, United States

Metropolitan Hospital; 🇬🇷 Peiraias, Greece

BioClinic Thessaloniki; 🇬🇷 Thessaloniki, Greece

MS Pnuemed - Janusz Milanowski, Katarzyna Szmygin-Milanowska Spolka Jawna; 🇵🇱 Lublin, Poland

The Champalimaud Centre for the Unknown; 🇵🇹 Lisbon, Portugal

"General Oncology Hospital of Kifisias "Agioi Anargyroi""; 🇬🇷 Nea Kifisia, Greece

General Hospital of Thessaloniki George Papanikolaou; 🇬🇷 Thessaloniki, Greece

Matrai Gyogyintezet; 🇭🇺 Gyongyos, Hungary

Instituto Portugues De Oncologia De Lisboa Francisco Gentil; 🇵🇹 Lisbon, Portugal

Sisters of Charity of Leavenworth Health St. Marys; 🇺🇸 Billings, Montana, United States

Orszagos Koranyi Pulmonologiai Intezet; 🇭🇺 Budapest, Hungary

Uniklinikum Salzburg; 🇦🇹 Salzburg, Austria

Wiener Gesundheitsverbund - Klinik Ottakring; 🇦🇹 Wien, Austria

Henry Dunant Hospital Center; 🇬🇷 Athens, Greece

General Hospital for Thoracic Diseases Sotiria; 🇬🇷 Athens, Greece

University General Hospital of Larissa; 🇬🇷 Larissa, Greece

Interbalkan Medical Center of Thessaloniki; 🇬🇷 Thessaloniki, Greece

Orszagos Onkologiai Intezet; 🇭🇺 Budapest, Hungary

Fejer Varmegyei Szent Gyorgy Egyetemi Oktato Korhaz; 🇭🇺 Szekesfehervar, Hungary

St. Vincents University Hospital; 🇮🇪 Dublin, Ireland

Unidade Local de Saude de Braga, E. P. E (Hospital de Braga); 🇵🇹 Braga, Portugal

SC OncoMed SRL; 🇷🇴 Timisoara, Romania

Hospital CUF Descobertas; 🇵🇹 Lisbon, Portugal

The Meath Foundation; 🇮🇪 Tallaght, Dublin, Ireland

Cancer Center of Kansas - Wichita - Heritage Plaza; 🇺🇸 Wichita, Kansas, United States

SCL Health - Saint Joseph Hospital Cancer Center; 🇺🇸 Lafayette, Colorado, United States

Oncocare Cancer Centre; 🇸🇬 Singapore, Singapore

City of Hope - Duarte (Main Campus); 🇺🇸 Duarte, California, United States

Ovidius Clinical Hospital; 🇷🇴 Ovidiu, Romania

Specjalistyczna Praktyka Lekarska Slawomir Mandziuk; 🇵🇱 Lublin, Poland

Maastricht Universitair Medisch Centrum; 🇳🇱 Maastricht, Netherlands

Istituto Europeo di Oncologia; 🇮🇹 Milan, Italy

Icon Cancer Centre Farrer Park; 🇸🇬 Singapore, Singapore

Cha Bundang Medical Center; 🇰🇷 Seongnam-si, Korea, Republic of

Bekes Megyei Kozponti Korhaz - Pandy Kalman Tagkorhaz; 🇭🇺 Gyula, Hungary

Instytut MSF; 🇵🇱 Lodz, Poland

Mazowieckie Centrum Leczenia Chorob Pluc I Gruzlicy; 🇵🇱 Otwock, Poland

Unidade Local de Saude de Coimbra; 🇵🇹 Coimbra, Portugal

Unidade Local de Saude de Santo Antonio, E. P. E - Hospital Geral de Santo Antonio; 🇵🇹 Porto, Portugal

Amsterdam Universitair Medische Centra (UMC) - Locatie Vrije Universiteit Medisch Centrum; 🇳🇱 Amsterdam, Netherlands

Chungbuk National University Hospital; 🇰🇷 Cheongju-si, Korea, Republic of

Kyungpook National University Chilgok Hospital; 🇰🇷 Daegu, Korea, Republic of

Azienda Ospedaliera Universitaria Integrata Verona; 🇮🇹 Verona, Italy

Pusan National University Hospital; 🇰🇷 Busan-si, Korea, Republic of

Kosin University Gospel Hospital; 🇰🇷 Busan, Korea, Republic of

Mruk-Med I Sp. z o.o.; 🇵🇱 Rzeszow, Poland

Pratia Poznan; 🇵🇱 Skorzewo, Poland

Wojewodzki Szpital Zespolony im. L. Rydygiera w Toruniu; 🇵🇱 Torun, Poland

Unidade Local de Saude da Arrabida, E. P. E (Centro Hospitalar de Setubal); 🇵🇹 Setubal, Portugal

Institutul Oncologic Prof. Dr. Ion Chiricuta; 🇷🇴 Cluj-Napoca, Romania

Medisprof; 🇷🇴 Cluj-Napoca, Romania

Centrul de Oncologie Sf Nectarie; 🇷🇴 Craiova, Romania

Centrul de Oncologie Euroclinic; 🇷🇴 Iasi, Romania

Raffles Hospital; 🇸🇬 Singapore, Singapore

Parkway Cancer Centre - Gleneagles Hospital; 🇸🇬 Singapore, Singapore

Hospital Clinico San Carlos; 🇪🇸 Madrid, Spain

Konkuk University Medical Center; 🇰🇷 Seoul, Korea, Republic of

Hospital Universitario Lucus Augusti; 🇪🇸 Lugo, Spain

Unidade Local de Saude do Alto Ave, E. P. E (Hospital da Senhora da Oliveira Guimaraes); 🇵🇹 Guimaraes, Portugal

Hospital CUF Porto; 🇵🇹 Porto, Portugal

Unidade Local de Saude de Entre Douro e Vouga, E. P. E; 🇵🇹 Santa Maria Da Feira, Portugal

Unidade Local de Saude de Gaia/Espinho, E. P. E; 🇵🇹 Vila Nova de Gaia, Portugal

Centrul Oncologic Sanador; 🇷🇴 București, Romania

Oncocenter - Oncologie Clinica; 🇷🇴 Timișoara, Romania

PanOncology Trials - Rio Piedras Medical Center; 🇵🇷 San Juan, Puerto Rico

Universitair Medisch Centrum Utrecht; 🇳🇱 Utrecht, Netherlands

The Catholic University of Korea - Seoul St. Marys Hospital; 🇰🇷 Seoul, Korea, Republic of

State Budgetary Healthcare Institution of the Nizhny Novgorod Region Clinical Diagnostic Center; 🇷🇺 Nizhniy Novgorod, Russian Federation

Ajou University Hospital; 🇰🇷 Suwon-si, Korea, Republic of

Instituto Portugues de Oncologia de Coimbra Francisco Gentil; 🇵🇹 Coimbra, Portugal

Unidade Local de Saude de Loures-Odivelas, EPE (Hospital Beatriz Angelo); 🇵🇹 Loures, Portugal

Oncolab Craiova; 🇷🇴 Craiova, Romania

Fundacion de Investigacion de Diego Clinical Research; 🇵🇷 San Juan, Puerto Rico

Complejo Hospitalario Universitario A Coruna; 🇪🇸 A Coruna, Spain

Hospital Universitari Vall dHebron; 🇪🇸 Barcelona, Spain

EuroCityClinic LLC; 🇷🇺 Saint Petersburg, Russian Federation

Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy; 🇵🇱 Warszawa, Poland

Unidade Local de Saude de Almada-Seixal, E. P. E (Hospital Garcia de Orta); 🇵🇹 Almada, Portugal

Instituto Portugues de Oncologia do Porto Francisco Gentil; 🇵🇹 Porto, Portugal

Spitalul Jude�ean de Urgen�a dr. Constantin Opri� Baia Mare; 🇷🇴 Baia Mare, Romania

SC Policlinica de Diagnostic Rapid SA; 🇷🇴 Brașov, Romania

National Cancer Centre Singapore; 🇸🇬 Singapore, Singapore

Hospital Beata Maria Ana; 🇪🇸 Madrid, Spain

Hospital Universitario Fundacion Jimenez Diaz; 🇪🇸 Madrid, Spain

Consorci Hospital General Universitari de Valencia; 🇪🇸 Valencia, Spain

Institutul Oncologic Bucuresti - Prof. Dr. Alexandru Trestioreanu; 🇷🇴 Bucharest, Romania

VitaMed - Moscow; 🇷🇺 Moscow, Russian Federation

Hospital del Mar - Parc de Salut Mar; 🇪🇸 Barcelona, Spain

Hospital Universitari Dexeus; 🇪🇸 Barcelona, Spain

Hospital General Universitario Dr. Balmis; 🇪🇸 Alicante, Spain

Hospital Universitario Cruces; 🇪🇸 Barakaldo, Spain

Universitatsspital Basel; 🇨🇭 Basel, Switzerland

Kantonsspital Winterthur; 🇨🇭 Winterthur, Switzerland

Azienda Ospedaliero - Universitaria - Policlinico - Vittorio Emanuele; 🇮🇹 Catania, Italy

University Hospital Birmingham NHS Foundation Trust; 🇬🇧 Birmingham, United Kingdom

University Hospitals of Leicester NHS Trust; 🇬🇧 Leicester, United Kingdom

The Christie NHS Foundation Trust; 🇬🇧 Manchester, United Kingdom

NHS Lothian; 🇬🇧 Edinburgh, United Kingdom

NHS Greater Glasgow and Clyde; 🇬🇧 Glasgow, United Kingdom

Hopital Arnaud de Villeneuve; 🇫🇷 Montpellier, France

University Headache Clinic; 🇷🇺 Moscow, Russian Federation

"Budgetary Healthcare Institution of Omsk region "Clinical Oncologic Dispensary""; 🇷🇺 Omsk, Russian Federation

"Limited Liability Company Medical Sanitary Unit "Clinicist-Clinic Pretor""; 🇷🇺 Novosibirsk, Russian Federation

Hospital Universitario Reina Sofia; 🇪🇸 Cordoba, Spain

Hospital de Leon; 🇪🇸 Leon, Spain

Hospital Universitario Virgen de las Nieves; 🇪🇸 Granada, Spain

Clinica Universidad de Navarra - Madrid; 🇪🇸 Madrid, Spain

Institut Catala dOncologia Girona (ICO Girona); 🇪🇸 Girona, Spain

Hospital Universitario 12 de Octubre; 🇪🇸 Madrid, Spain

Hospital Universitario Son Espases; 🇪🇸 Palma de Mallorca, Spain

Hospital Universitario Marques de Valdecilla; 🇪🇸 Santander, Spain

Hospital Universitari i Politecnic La Fe; 🇪🇸 Valencia, Spain

Hospital Clinico Universitario Lozano Blesa; 🇪🇸 Zaragoza, Spain

Keimyung University Dongsan Hospital; 🇰🇷 Daegu, Korea, Republic of

Gachon University Gil Medical Center; 🇰🇷 Incheon, Korea, Republic of

Inje University Haeundae Paik Hospital; 🇰🇷 Busan, Korea, Republic of

Inha University Hospital; 🇰🇷 Jung-Gu, Korea, Republic of

Korea University Anam Hospital; 🇰🇷 Seoul, Korea, Republic of

Severance Hospital - Yonsei Cancer Center; 🇰🇷 Seoul, Korea, Republic of

Catholic University of Korea Saint Vincents Hospital; 🇰🇷 Suwon-Si, Korea, Republic of

Franciscan Health Cancer Center Indianapolis; 🇺🇸 Indianapolis, Indiana, United States

Utah Cancer Specialists - UCS Cancer Center; 🇺🇸 Salt Lake City, Utah, United States

Providence Medical Group - Santa Rosa; 🇺🇸 Santa Rosa, California, United States

Rocky Mountain Cancer Centers - Lone Tree; 🇺🇸 Lone Tree, Colorado, United States

21st Century Oncology of Jacksonville - North Lee Street; 🇺🇸 Jacksonville, Florida, United States

Cancer Specialists of North Florida - Southpoint; 🇺🇸 Jacksonville, Florida, United States

USOR - Woodlands Medical Specialists; 🇺🇸 Pensacola, Florida, United States

Northwest Georgia Oncology Centers Wellstar - Marietta; 🇺🇸 Marietta, Georgia, United States

University Cancer & Blood Center (UCBC) - Athens; 🇺🇸 Athens, Georgia, United States

Illinois Cancer Specialists - Niles; 🇺🇸 Niles, Illinois, United States

Goshen Center for Cancer Care; 🇺🇸 Goshen, Indiana, United States

Franciscan Health Munster; 🇺🇸 Munster, Indiana, United States

Baptist Health Lexington; 🇺🇸 Lexington, Kentucky, United States

Frederick Health; 🇺🇸 Frederick, Maryland, United States

Central Care Cancer Center - Bolivar; 🇺🇸 Bolivar, Missouri, United States

St. Vincent Healthcare Cancer Centers of Montana; 🇺🇸 Billings, Montana, United States

Kettering Health Cancer Center - Main Campus; 🇺🇸 Kettering, Ohio, United States

SUNY Upstate Medical University; 🇺🇸 Syracuse, New York, United States

Oregon Oncology Specialists; 🇺🇸 Salem, Oregon, United States

Texas Oncology Dallas Fort Worth West (DFWW) - Arlington Cancer Center North; 🇺🇸 Arlington, Texas, United States

Klinikum Klagenfurt Am Worthersee; 🇦🇹 Klagenfurt Am Woerthersee, Austria

Texas Oncology - South Austin; 🇺🇸 Austin, Texas, United States

Texas Oncology - Sherman; 🇺🇸 Sherman, Texas, United States

UVA Health - University Hospital; 🇺🇸 Charlottesville, Virginia, United States

Monash Health; 🇦🇺 Clayton, Australia

GenesisCare - North Shore; 🇦🇺 St. Leonards, Australia

Princess Alexandra Hospital; 🇦🇺 Woolloongabba, Australia

The Tweed Hospital; 🇦🇺 Tweed Heads, Australia

Townsville University Hospital; 🇦🇺 Douglas, Australia

Grand Hopital de Charleroi - Notre Dame; 🇧🇪 Charleroi, Belgium

Universitair Ziekenhuis Antwerpen; 🇧🇪 Edegem, Belgium

Algemeen Ziekenhuis Maria Middelares; 🇧🇪 Gent, Belgium

Jessa Ziekenhuis - Campus Virga Jesse; 🇧🇪 Hasselt, Belgium

Fakultni Nemocnice Olomouc; 🇨🇿 Olomouc, Czechia

Centre Hospitalier Universitaire Universite Catholique de Louvain - Site Godinne; 🇧🇪 Yvoir, Belgium

Multiscan - Ambulance klinicke onkologie se stacionarem - Horovice; 🇨🇿 Horovice, Czechia

Centre Hospitalier Universitaire de Caen Normandie; 🇫🇷 Caen Cedex 09, France

Hopital Morvan; 🇫🇷 Brest, France

Fakultni nemocnice Bulovka; 🇨🇿 Praha 8 - Liben, Czechia

Hopital Louis Pradel; 🇫🇷 Bron, France

Centre Francois Baclesse; 🇫🇷 Caen Cedex 5, France

Centre Hospitalier Intercommunal de Creteil; 🇫🇷 Creteil, France

Centre Georges Francois Leclerc; 🇫🇷 Dijon cedex, France

LHopital Nord-Ouest (HNO) - Villefranche-sur-Saone; 🇫🇷 Gleize, France

Centre Hospitalier Universitaire Dupuytren 1; 🇫🇷 Limoges cedex, France

Centre Hospitalier Regional Universitaire de Lille; 🇫🇷 Lille Cedex, France

Hopital Nord de Marseille; 🇫🇷 Marseille, France

Institut Paoli-Calmettes; 🇫🇷 Marseille, France

Hopital Emile Muller; 🇫🇷 Mulhouse, France

Institut de Cancerologie de lOuest - Saint-Herblain - Site Rene Gauducheau; 🇫🇷 Saint Herblain, France

Centre Antoine Lacassagne; 🇫🇷 Nice Cedex 2, France

Centre Hospitalier de Cornouaille - Hopital Laennec; 🇫🇷 Quimper, France

Institut de Cancerologie Strasbourg Europe; 🇫🇷 Strasbourg, France

Zentralklinik Bad Berka; 🇩🇪 Bad Berka, Germany

Hopital Bretonneau; 🇫🇷 Tours Cedex 9, France

Gustave Roussy; 🇫🇷 Villejuif, France

Asklepios Fachkliniken Munchen-Gauting; 🇩🇪 Gauting, Germany

Universitatsklinikum Gieen und Marburg - Gieen; 🇩🇪 Giessen, Germany

Krankenhaus Martha-Maria Halle-Dolau; 🇩🇪 Halle, Germany

LungenClinic Grosshansdorf; 🇩🇪 Grohansdorf, Germany

Universitatsklinikum Jena; 🇩🇪 Jena, Germany

Klinikum Koln-Merheim; 🇩🇪 Koln, Germany

Klinikum Kassel; 🇩🇪 Kassel, Germany

SLK-Kliniken - Fachklinik Lowenstein; 🇩🇪 Lowenstein, Germany

Munchen Klinik Bogenhausen; 🇩🇪 Munchen, Germany

Universitatsklinikum Schleswig-Holstein - Campus Lubeck; 🇩🇪 Lubeck, Germany

Sana Klinikum Offenbach; 🇩🇪 Offenbach, Germany

Pius-Hospital Oldenburg; 🇩🇪 Oldenburg, Germany

University General Hospital of Heraklion (PAGNI); 🇬🇷 Heraklion, Greece

Anassa General Clinic; 🇬🇷 Volos, Greece

Semmelweis Egyetem - Pulmonologiai Klinika; 🇭🇺 Budapest, Hungary

Reformatus Pulmonologiai Centrum; 🇭🇺 Torokbalint, Hungary

Beaumont Hospital - Dublin; 🇮🇪 Dublin, Ireland

St. Jamess Hospital; 🇮🇪 Dublin, Ireland

University Hospital Galway; 🇮🇪 Galway, Ireland

Azienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare Arrigo - Alessandria; 🇮🇹 Alessandria, Italy

University Hospital Limerick; 🇮🇪 Limerick, Ireland

Azienda Ospedaliera San Giuseppe Moscati - Avellino; 🇮🇹 Avellino, Italy

Centro di Riferimento Oncologico; 🇮🇹 Aviano, Italy

Istituto Tumori Bari Giovanni Paolo II - IRCCS; 🇮🇹 Bari, Italy

Azienda Socio Sanitaria Territoriale (ASST) degli Spedali Civili di Brescia; 🇮🇹 Brescia, Italy

Istituto di Candiolo - Fondazione del Piemonte per lOncologia; 🇮🇹 Candiolo, Italy

Fondazione IRCCS - Istituto Nazionale dei Tumori; 🇮🇹 Milano, Italy

Azienda Ospedaliera di Rilievo Nazionale e di Alta Specializzazione Garibaldi; 🇮🇹 Catania, Italy

Azienda Ospedaliero - Universitaria Careggi; 🇮🇹 Firenze, Italy

ASL 3 Genovese - Ospedale Villa Scassi - Sampierdarena; 🇮🇹 Genova, Italy

Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) - Ospedale Policlinico San Martino; 🇮🇹 Genova, Italy

Ospedale Vito Fazzi Lecce; 🇮🇹 Lecce, Italy

"Istituto Romagnolo per lo Studio dei Tumori "Dino Amadori" - IRST"; 🇮🇹 Meldola, Italy

Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) - Ospedale San Raffaele; 🇮🇹 Milan, Italy

Azienda Ospedaliero-Universitaria Maggiore della Carita di Novara; 🇮🇹 Novara, Italy

Azienda Ospedaliera Universitaria - Universita degli Studi della Campania Luigi Vanvitelli; 🇮🇹 Napoli, Italy

Istituto Nazionale Tumori IRCCS Fondazione G. Pascale; 🇮🇹 Napoli, Italy

Azienda Ospedaliero-Universitaria di Parma; 🇮🇹 Parma, Italy

Azienda Ospedaliera Ospedali Riuniti Marche Nord; 🇮🇹 Pesaro, Italy

Azienda Ospedaliera di Perugia - Santa Maria della Misericordia; 🇮🇹 Perugia, Italy

Ospedale Santa Maria delle Croci di Ravenna; 🇮🇹 Ravenna, Italy

Hagaziekenhuis Van Den Haag - Leyweg; 🇳🇱 Den Haag, Netherlands

St. Antonius Ziekenhuis - Ziekenhuis Utrecht; 🇳🇱 Utrecht, Netherlands

Radboud Universitair Medisch Centrum; 🇳🇱 Nijmegen, Netherlands

Wojskowy Instytut Medyczny; 🇵🇱 Warsaw, Poland

Puerto Rico Medical Research Center; 🇵🇷 San Juan, Puerto Rico

Evimed Oncology Clinic; 🇷🇺 Chelyabinsk, Russian Federation

"Regional Budgetary Healthcare Institution "G.E. Ostroverkhov Kursk Oncology Scientific and Clinical Center" of the Healthcare C; 🇷🇺 Kislino Village, Russian Federation

Hospital Germans Trias i Pujol; 🇪🇸 Badalona, Spain

Complejo Hospitalario Universitario Insular Materno Infantil; 🇪🇸 Las Palmas de Gran Canaria, Spain

Hospital Universitario Ramon y Cajal; 🇪🇸 Madrid, Spain

Hospital Universitario Puerta de Hierro - Majadahonda; 🇪🇸 Majadahonda, Spain

Hospital Regional Universitario de Malaga - Hospital Civil; 🇪🇸 Malaga, Spain

TOI Clinical Research (ICIR); 🇺🇸 Cerritos, California, United States

University of Chicago; 🇺🇸 Chicago, Illinois, United States

Local Institution - 012-999; 🇺🇸 Irving, Texas, United States

Hopital Civil; 🇫🇷 Strasbourg cedex, France

Cancer Care Wollongong; 🇦🇺 Wollongong, Australia

Astera Cancer Care - East Brunswick; 🇺🇸 East Brunswick, New Jersey, United States

Holy Name Medical Center; 🇺🇸 Teaneck, New Jersey, United States

Lifespan Cancer Institute - Rhode Island Hospital; 🇺🇸 Providence, Rhode Island, United States

Prisma Health Cancer Institute - Faris Road; 🇺🇸 Greenville, South Carolina, United States

Flinders Medical Centre; 🇦🇺 Bedford Park, Australia

Hopital Michallon; 🇫🇷 La Tronche, France

Kliniken Essen-Mitte - Evangelische Huyssens-Stiftung; 🇩🇪 Essen, Germany

Universitatsklinikum Bonn; 🇩🇪 Bonn, Germany

Seoul National University Bundang Hospital; 🇰🇷 Seongnam-si, Korea, Republic of

"Budgetary Healthcare Institution of the Udmurt Republic "Republican Clinical Oncological Dispensary n.a. Sergey Grigoryevich Pr; 🇷🇺 Izhevsk, Russian Federation

Asan Medical Center; 🇰🇷 Seoul, Korea, Republic of

Saint Petersburg Clinical Scientific & Practical Center for Specialized Types of Medical Care (Oncology); 🇷🇺 Saint Petersburg, Russian Federation

"Federal State Budgetary Institution "Influenza Research Institute named after N.N. A.A. Smorodintsev" of the Ministry of Health; 🇷🇺 Saint-Petersburg, Russian Federation

Hospital Clinic de Barcelona; 🇪🇸 Barcelona, Spain

Orlando Health University of Florida Health Cancer Center - Head and Neck Center; 🇺🇸 Orlando, Florida, United States

Algemeen Ziekenhuis Delta - Campus Rumbeke; 🇧🇪 Roeselare, Belgium

Universitair Ziekenhuis Brussel; 🇧🇪 Brussel, Belgium

Algemeen Ziekenhuis Glorieux Ronse; 🇧🇪 Ronse, Belgium

Avera Cancer Institute; 🇺🇸 Sioux Falls, South Dakota, United States

University of Kansas Medical Center; 🇺🇸 Westwood, Kansas, United States

Prince of Wales Hospital - Hong Kong; 🇭🇰 Hong Kong, Hong Kong

Hong Kong United Oncology Centre; 🇭🇰 Kowloon, Hong Kong

Humanity & Health Clinical Trial Centre; 🇭🇰 Central, Hong Kong