Aerobic Exercise Training in Pulmonary Arterial Hypertension

Not Applicable

Completed

• Conditions: Pulmonary Arterial Hypertension
• Interventions: Other: Upper extremity aerobic exercise training; Other: Alternative upper extremity exercises

• Registration Number: NCT02371733
• Lead Sponsor: Gazi University

Brief Summary

Decreased exercise capacity, peripheral muscle strength and quality of life and increased dyspnea and fatigue perception is prevalent in patients with pulmonary arterial hypertension. It was demonstrated exercise training has beneficial effects in patients with pulmonary arterial hypertension. However, no study investigated the effects of upper extremity aerobic exercise training, therefore effects of upper extremity aerobic exercise training on outcomes in patients with pulmonary arterial hypertension.

Detailed Description

Patients were diagnosed with pulmonary arterial hypertension according to the Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of f the European Society of Cardiology (ESC) and European Respiratory Society (ERS). Primary outcome measurement was exercise capacity, secondary outcomes were respiratory and peripheral muscle strength, physical activity, quality of life, fatigue, dyspnea and depression.

Study Timeline

• Study First Submitted: 2015-02-20
• Study First Submitted QC: 2015-02-20
• Study First Posted: 2015-02-26
• Study Start: 2015-04
• Primary Completion: 2018-01
• Study Completion: 2018-04
• Status Verified: 2019-02
• Last Update Submitted: 2019-02-13
• Last Update Posted: 2019-02-15

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• Clinically stable
• Under standard medication
• Group 1 pulmonary arterial hypertension patients
• Having no exacerbation or infection

Exclusion Criteria

• Cognitive disorders
• Orthopedic and neurological problems
• Pneumonia or acute infection
• Stage 4 heart failure
• Having no comorbidity to avoid performing evaluation and training

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Training Group	Upper extremity aerobic exercise training	Intervention:Training group will receive upper extremity aerobic exercise training using arm ergometer and breathing exercises.
Control Group	Alternative upper extremity exercises	Sham: Control group will receive alternative upper extremity exercises and breathing exercises.

Primary Outcome Measures

Name	Time	Method
Functional exercise capacity (Oxygen consumption measurement during test)	6 weeks	Six minute walk test (6MWT)

Secondary Outcome Measures

Name	Time	Method
Maximum inspiratory and expiratory muscle strength (MIP, MEP)	6 weeks	Mouth pressure device
Peripheral muscle strength	6 weeks	Hand held dynamometer
Pulmonary functions	6 week	Spirometry
Physical activity	6 weeks	Activity monitor
Dyspnea	6 weeks	Modified Borg and Modified Medical Research Council (MMRC) dyspnea scales
Fatigue	6 weeks	Fatigue Severity Scale (FSS)
Generic quality of life	6 weeks	Short Form (SF-36) Health Survey
Depression	6 weeks	Montgomery Asberg Depression Rating Scale (MADRS) (Turkish versions of all scales)

Trial Locations

Locations (1)

Gazi University; 🇹🇷 Ankara, Turkey