Neural Mechanisms Underlying Attention Lapses in Adult Attention Deficit Disorder: Towards a Better Clinical Diagnosis
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Attention Deficit Disorder
- Sponsor
- University Hospital, Strasbourg, France
- Enrollment
- 63
- Locations
- 1
- Primary Endpoint
- Spectral amplitude of the alpha band (8-14 Hz) to the quantitative EEG during the period up to 20 seconds before the successful trials vs. missed trials (lapse).
- Status
- Completed
- Last Updated
- 3 years ago
Overview
Brief Summary
ADHD is a common disorder, leading to a significant disability that often persists in adulthood. ADHD is characterized by attentional disturbances that are difficult to asses with standard neuropsychological tests.
Attention tends to stall after a certain time of fatigue (i.e. an attention lapse). The aim of this study is to study the electroencephalographic (EEG) characteristics of these attention lapses in a sustained attention task, comparing ADHD patients with healthy subjects.
Detailed Description
The main goal is to assess with EEG the timing of the attentional demobilization that precedes a sustained attention lapse in patients with ADHD. The secondary objectives are: 1 / To analyze impaired cognitive control mechanisms during lapses in patients with ADHD; 2 / Study the relationships between the deficits identified through EEG recording, clinical evaluations, and the subjective perception of daily difficulties; 3 / To measure the impact of the subjective attention state on the neuronal precursors of the attentional lapses; 4 / Evaluate the relation between propensity to wandering mind and attentional lapses.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Diagnosis of ADHD according to DSM-5 criteria by a psychiatrist with clinical experience with ADHD
- •aged 18 to 60
- •having signed an informed consent
- •able to understand the objectives and the risks related to the research
- •For Healthy controls
- •Absence of psychiatric disorder or neurological disease
- •Matched in sex, age (± 2 years) and level of study (± 2 years) to each ADHD patient
- •Exclusion criteria:
- •treatment by Methylphenidate or amphetamine in the 3 months preceding the study
- •treatment by a psychotropic drug other than antidepressant SSRI: anti-depressant non-SSRI, antipsychotic, mood stabilizer, benzodiazepine or hypnotic daily intake
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Spectral amplitude of the alpha band (8-14 Hz) to the quantitative EEG during the period up to 20 seconds before the successful trials vs. missed trials (lapse).
Time Frame: During EEG realized after the inclusion
In healthy subjects, EEG changes, including increased parieto-occipital activity in the alphas frequency band (8-14Hz), have been observed 20 seconds before lapse (O'Connell et al., 2009). The analysis of the evoked potentials associated with the stimuli presented just before the occurrence of the target stimulus, reveals that the amplitude of the P300 on the 5 trials preceding the target to be detected is significantly lower before an omission (lapse) than before a correct detection.
Secondary Outcomes
- CNV difference between missed and successful trials(During EEG realized after the inclusion)
- Association between EEG lapses markers, neuropsychological measures of attention, clinical scales and subjective mindwandering(During EEG realized after the inclusion)
- EEG lapse markers according attentional subjective state(During EEG realized after the inclusion)