Neural Mechanisms of Attention Lapses in Adult ADHD
- Conditions
- Hyperactivity DisorderAttention Deficit Disorder
- Interventions
- Other: Electroencephalography during sustained attention task.
- Registration Number
- NCT03948607
- Lead Sponsor
- University Hospital, Strasbourg, France
- Brief Summary
ADHD is a common disorder, leading to a significant disability that often persists in adulthood. ADHD is characterized by attentional disturbances that are difficult to asses with standard neuropsychological tests.
Attention tends to stall after a certain time of fatigue (i.e. an attention lapse). The aim of this study is to study the electroencephalographic (EEG) characteristics of these attention lapses in a sustained attention task, comparing ADHD patients with healthy subjects.
- Detailed Description
The main goal is to assess with EEG the timing of the attentional demobilization that precedes a sustained attention lapse in patients with ADHD.
The secondary objectives are: 1 / To analyze impaired cognitive control mechanisms during lapses in patients with ADHD; 2 / Study the relationships between the deficits identified through EEG recording, clinical evaluations, and the subjective perception of daily difficulties; 3 / To measure the impact of the subjective attention state on the neuronal precursors of the attentional lapses; 4 / Evaluate the relation between propensity to wandering mind and attentional lapses.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 63
- Diagnosis of ADHD according to DSM-5 criteria by a psychiatrist with clinical experience with ADHD
- aged 18 to 60
- having signed an informed consent
- able to understand the objectives and the risks related to the research
For Healthy controls
- Absence of psychiatric disorder or neurological disease
- Matched in sex, age (± 2 years) and level of study (± 2 years) to each ADHD patient
Exclusion criteria:
- treatment by Methylphenidate or amphetamine in the 3 months preceding the study
- treatment by a psychotropic drug other than antidepressant SSRI: anti-depressant non-SSRI, antipsychotic, mood stabilizer, benzodiazepine or hypnotic daily intake
- neurological pathology or neurological sequelae
- history of head trauma with loss of consciousness of more than 15 minutes
- Subject under the protection of justice
- Subject under guardianship, curatorship
- Subject in exclusion period (determined by previous or current study),
- Impossibility to give the subject enlightened information (subject in emergency situation, difficulties of comprehension of the subject (for example mental retardation, illiteracy, subject not including French ...)
Not provided
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Adult ADHD Electroencephalography during sustained attention task. Adult ADHD patients without current comorbidity and treatment. Healthy controls Electroencephalography during sustained attention task. Healthy controls without ADH, paired in age and gender.
- Primary Outcome Measures
Name Time Method Spectral amplitude of the alpha band (8-14 Hz) to the quantitative EEG during the period up to 20 seconds before the successful trials vs. missed trials (lapse). During EEG realized after the inclusion In healthy subjects, EEG changes, including increased parieto-occipital activity in the alphas frequency band (8-14Hz), have been observed 20 seconds before lapse (O'Connell et al., 2009). The analysis of the evoked potentials associated with the stimuli presented just before the occurrence of the target stimulus, reveals that the amplitude of the P300 on the 5 trials preceding the target to be detected is significantly lower before an omission (lapse) than before a correct detection.
- Secondary Outcome Measures
Name Time Method CNV difference between missed and successful trials During EEG realized after the inclusion Time course analysis of electrophysiological markers (EEG) after a successful test: amplitude of the evoked potentials and theta power (intensity in μV).
Association between EEG lapses markers, neuropsychological measures of attention, clinical scales and subjective mindwandering During EEG realized after the inclusion Regression and correlation analyzes involving electrophysiological markers associated with subjective measures of mind wandering (ad hoc questionnaire)
EEG lapse markers according attentional subjective state During EEG realized after the inclusion amplitude electrophysiological markers (EEG) of attentional lapses (evoked potentials P3a and CNV, theta power) (intensity in μV), according to the attentional state described by the subjects during the evaluations during the task
Trial Locations
- Locations (1)
Hôpital Civil - service de Psychiatrie 2
🇫🇷Strasbourg, France