Cross Sectional Study to Evaluate and Associate Clinical and Laboratory Features of People With Allergic and Non-allergic Asthma
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 105
- 试验地点
- 1
- 主要终点
- Serum periostin level
研究概览
简要总结
In the past, doctors separated people with asthma into two groups, those with "allergic asthma" (about 2/3rds of people) and those with "non-allergic asthma". These labels are not much used now as the treatments for all people with asthma don't depend on this classification. However, new treatments for asthma may become available and the classification may again become important. It could be useful for clinicians to know how to identify which patients are likely to benefit from particular treatments.
Additionally, some new blood tests are becoming available and some of these might help to categorise the type of asthma people have. What the study hopes to do is to identify patient features which make a diagnosis of "allergic asthma" more likely and to see which new blood tests are most likely to be helpful in confirming this diagnosis.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Male and female patients aged 18 years old and over with a diagnosis of asthma and having received at least two prescriptions for any asthma medication in the last 12 months, who have signed an informed consent form prior to initiation of any study-related procedure
排除标准
- •under 18 years
- •current smokers
- •unwilling or unable to give informed consent
- •a clinical diagnosis of COPD
- •a history of anaphylaxis (skin prick test)
- •participated in any clinical study in the last 12 months
结局指标
主要结局
Serum periostin level
时间窗: 1 day
This is a cross sectional study. Participants will be assessed and tests conducted at a single visit
次要结局
- Blood eosinophils expressing CRTh2(1 day)
- skin prick test(1 day)
- Blood CD4 cells that are positive for CRTh2(1 day)
- Blood eosinophil count(1 day)
- Serum total IgE(1 day)
- Blood neutrophil count(1 day)
- Spirometry(1 day)
