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临床试验/NCT01618318
NCT01618318已完成不适用

Cross Sectional Study to Evaluate and Associate Clinical and Laboratory Features of People With Allergic and Non-allergic Asthma

National Services for Health Improvement Ltd1 个研究点 分布在 1 个国家目标入组 105 人开始时间: 2012年6月最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
发起方
入组人数
105
试验地点
1
主要终点
Serum periostin level

研究概览

简要总结

In the past, doctors separated people with asthma into two groups, those with "allergic asthma" (about 2/3rds of people) and those with "non-allergic asthma". These labels are not much used now as the treatments for all people with asthma don't depend on this classification. However, new treatments for asthma may become available and the classification may again become important. It could be useful for clinicians to know how to identify which patients are likely to benefit from particular treatments.

Additionally, some new blood tests are becoming available and some of these might help to categorise the type of asthma people have. What the study hopes to do is to identify patient features which make a diagnosis of "allergic asthma" more likely and to see which new blood tests are most likely to be helpful in confirming this diagnosis.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Cross Sectional

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Male and female patients aged 18 years old and over with a diagnosis of asthma and having received at least two prescriptions for any asthma medication in the last 12 months, who have signed an informed consent form prior to initiation of any study-related procedure

排除标准

  • under 18 years
  • current smokers
  • unwilling or unable to give informed consent
  • a clinical diagnosis of COPD
  • a history of anaphylaxis (skin prick test)
  • participated in any clinical study in the last 12 months

结局指标

主要结局

Serum periostin level

时间窗: 1 day

This is a cross sectional study. Participants will be assessed and tests conducted at a single visit

次要结局

  • Blood eosinophils expressing CRTh2(1 day)
  • skin prick test(1 day)
  • Blood CD4 cells that are positive for CRTh2(1 day)
  • Blood eosinophil count(1 day)
  • Serum total IgE(1 day)
  • Blood neutrophil count(1 day)
  • Spirometry(1 day)

研究者

发起方
National Services for Health Improvement Ltd
申办方类型
Industry
责任方
Sponsor

研究点 (1)

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