A Single-center Observational Study Investigating the Effect of Volatile Conditioning (VC) With Sevoflurane on Myocardial Biomarkers and Platelets Function in Patients Having Minimally Invasive Mitral Valve Surgery (MIMV)
Overview
- Phase
- Not Applicable
- Intervention
- sevofluorane
- Conditions
- Myocardial Ischemia
- Sponsor
- Fondazione Toscana Gabriele Monasterio
- Enrollment
- 48
- Locations
- 1
- Primary Endpoint
- Myocardial Injury assessed by changes in Troponin values
- Last Updated
- 10 years ago
Overview
Brief Summary
The main aim of this study is to compare markers of cardiac injury (Troponin I), inflammatory response and platelets function during minimally invasive mitral valve repair or replacement (MIMV) via right mini-thoracotomy in two standard anaesthetic regimes (sevo \propofol)
Detailed Description
The main aim of this study is to compare markers of cardiac injury (Troponin I), inflammatory response and platelets function during minimally invasive mitral valve repair or replacement (MIMV) via right mini-thoracotomy in two standard anaesthetic regimes: * Volatile conditioning (sevoflurane) used during induction (preconditioning) and during the operation as maintenance (perconditioning) and no propofol. * Propofol induction and maintenance (TIVA) and no volatile anaesthetics. Outlet/residual blood samples coming from routine check will be collected at different time points. Study will be powered on Troponin I (primary statistical outcome). Original secondary outcome will be considered: platelets activation, left ventricle function, clinical figures (length of stay, inotrops requirements, ventilation times and other relevant).
Investigators
MOSCARELLI MARCO
MD, PhD
Fondazione Toscana Gabriele Monasterio
Eligibility Criteria
Inclusion Criteria
- •Patients undergoing elective (or urgent) first-time minimal invasive mitral valve surgery.
Exclusion Criteria
- •Cardiogenic shock or cardiac arrest, emergent CABG
- •Renal failure (with a GFR \< 30 ml/min/1.73m2),
- •Glibenclamide or nicorandil (as these medications may interfere with VC)
- •Known intolerance/allergy to sevoflurane or propofol
Arms & Interventions
Sevofluorane
Patients preconditioned with Sevo
Intervention: sevofluorane
Outcomes
Primary Outcomes
Myocardial Injury assessed by changes in Troponin values
Time Frame: properatively-6, 12, 24, 48 and 72 hours after the end of ischaemic cardioplegic arrest
According to the routine post operative blood testing frame-time troponin sample will collected in the preoperative and postoperative period.