The effect of methotexate and hydroxychloroquine on lichen planopilaris
Phase 2
- Conditions
- Follicular lichen planusichen planopilaris.
- Registration Number
- IRCT2015062822959N1
- Lead Sponsor
- Vice Chancellor for Research, Isfahan University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Other
- Sex
- All
- Target Recruitment
- 24
Inclusion Criteria
Scalp involvement> 10% and no response to the previous 3-month topical or 6-month systemic medications; In the case of local involvement (<10% of scalp), resistance to the combination of topical and at least 6-month systemic therapy; the patients should be stopped all systemic medications at least 1 month before enrollment to the study.
Exclusion Criteria are as follow: pregnancy or lactation; Hb<9 mg/dl; WBC< 4000; platelet< 100000; liver enzymes> 2 times of upper limit of normal; and positive viral hepatic markers.
Withdrawal criteria include no show up in follow-up visits; discontinuing the medication by patient; administration of another immunosuppressive or topical medication by other physician.
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method ichen planopilaris activity index. Timepoint: Before and after intervention. Method of measurement: Checklist.;Standardized global photpgraphy. Timepoint: Before and after intervention. Method of measurement: Based on scoring by two deramtologist.
- Secondary Outcome Measures
Name Time Method