Antibiotic Prescribing Behavior Among French Intensivist: Construction and Validation of a Questionnaire

• Conditions: Antibiotic Reaction

• Registration Number: NCT04820062
• Lead Sponsor: Centre Hospitalier Universitaire de Saint Etienne

Brief Summary

Antibiotic resistance is a major threat in modern medicine. Overuse of antibiotics is an important driver of antibiotic resistance. However, some authors have shown that up to 50% of antibiotic treatments in critically ill patients are inappropriate, mostly because they are used in patients with non-bacterial infections.

In order to improve antibiotic use, several antibiotic stewardship programs have been implemented worldwide. However, only few of them have taken into account the determinants of prescribing behaviors. Yet, these determinants have been shown to play a role among general practitioners of hospital doctors. Nevertheless, none of these factors have been studied among intensivists.

The current project represent phase 1 of the study : construction and validation of a questionnaire.

Detailed Description

Antibiotic resistance is a major threat in modern medicine. Overuse of antibiotics is an important driver of antibiotic resistance. In critical care setting, antibiotic therapies are widely used due to the high number of patients presenting with sepsis. However, some authors have shown that up to 50% of antibiotic treatments in critically ill patients are inappropriate, mostly because they are used in patients with non-bacterial infections.

In order to improve antibiotic use, several antibiotic stewardship programs have been implemented worldwide. However, only few of them have taken into account the determinants of prescribing behaviors. Yet, these determinants have been shown to play a role among general practitioners of hospital doctors. Nevertheless, none of these factors have been studied among intensivists.

The study is designed to investigate social, cultural, contextual and personal factors influencing antibiotic prescribing among French intensivists. The design will consist of three phases:

* Phase 1: construction and validation of a questionnaire

* Phase 2: the questionnaire will be sent to all intensivist, including residents, in France

* Phase 3: qualitative study, based on semi-structured interviews.

The current project represent phase 1 of the study.

Study Timeline

• Study First Submitted: 2021-03-25
• Study First Submitted QC: 2021-03-25
• Study First Posted: 2021-03-29
• Status Verified: 2021-08
• Study Start: 2021-08
• Last Update Submitted: 2021-08-18
• Last Update Posted: 2021-08-19
• Primary Completion: 2022-09-01
• Study Completion: 2022-09-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 115

Inclusion Criteria

• Physicians with predominant intensive care practice
• Resident, with a minimum of two-month experience in the intensive care unit

Exclusion Criteria

• Refusal to participate

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Content validity	months 18	Construction and validation of a questionnaire by 2 experts in reanimation and infectiology.; This questionnaire will include these items: demographic datas, medical data concerning the use of antibiotics, social data exploring the collective and social components of antibiotic prescription, personal data in search of individual factors, attitude to antibiotic therapy.

Secondary Outcome Measures

Name	Time	Method
Face validity	months 18	the questionnaire will be sent to all intensivist, including residents, in France

Trial Locations

Locations (1)

Chu St Etienne; 🇫🇷 Saint-Étienne, France