Clinical Implication of DAC (Detrusor After-contraction)

Completed

• Conditions: Voiding Dysfunction

• Registration Number: NCT01154946
• Lead Sponsor: Seoul National University Hospital

Brief Summary

The aims of this study are

* to confirm whether detrusor after-contraction (DAC) is a true contraction or not with a new approach

* and to understand clinical implication of DAC

Detailed Description

The definition of detrusor after-contraction (DAC) is usually accepted as the increase of detrusor pressure (Pdet), whether it is sudden or not, after cessation of urinary flow. The amount of increase in Pdet is sometimes included in the definition of DAC (14, 15, 20 cmH2O or at least two times the level of the maximal Pdet during the voiding phase). However, it is clear that the lack of a well-established definition may induce much bias in the interpretation of the clinical implication of DAC. The previous studies showed a wide range of prevalence.1-4 DAC seemed to occur more frequently in children and the occurrence rate usually decreased with age in urodynamic studies.

Study Timeline

• Study Start: 2007-01
• Primary Completion: 2008-12
• Study Completion: 2008-12
• Status Verified: 2010-06
• Study First Submitted: 2010-06-29
• Study First Submitted QC: 2010-06-30
• Last Update Submitted: 2010-06-30
• Study First Posted: 2010-07-01
• Last Update Posted: 2010-07-01

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 2309

Inclusion Criteria

• Indications and selection of patients for conduction of urodynamic studies (UDS) were followed as the recommendation of ICS (international continence society).

Exclusion Criteria

• Patients with indwelling catheters, urinary tract infection and urinary stones were excluded from this study

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
to confirm whether DAC is a true contraction or not	up to 2 years (2007.Jan-2008.Dec)	no change of Pdet when patients cough could confirm that DAC was a true contraction. Because an artifact occurred when a catheter was pressed against bladder wall or urethra, no change of intravesical pressure and increase of abdominal pressure finally induced a negative deflection of Pdet and this change of Pdet could be regarded as an artifact.

Secondary Outcome Measures

Name	Time	Method
Past medical history including neurological disorders and pelvic irradiation were also included in the database	up to 2 years (2007.Jan-2008.Dec)	One-way analysis of variance and the chi-square test were performed to determine whether there was a relationship between the presence of DAC and the underlying neurogenic and non-neurogenic conditions

Trial Locations

Locations (1)

Seoul National University Hospital; 🇰🇷 Seoul, Korea, Republic of