Genetic Variability in Taste Perception

Monell Chemical Senses Center1 site in 1 country90 target enrollmentDecember 2012

ConditionsHealthy

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Healthy
Sponsor: Monell Chemical Senses Center
Enrollment: 90
Locations: 1
Primary Endpoint: Psychophysical data for taste solutions
Status: Completed
Last Updated: 10 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

This proposal describes a pilot study aimed at determining whether genetic variations in taste receptors determine differential taste tolerability of pediatric medications.

Detailed Description

This is a cross-sectional call-back study of taste perception and the relationship between taste perception and taste receptor genotype.

Registry

clinicaltrials.gov

Start Date

December 2012

End Date

December 2015

Last Updated

10 years ago

Study Type

Observational

Sex

Female

Investigators

Sponsor

Monell Chemical Senses Center

Responsible Party

Principal Investigator

Julie A. Mennella

Member

Monell Chemical Senses Center

Eligibility Criteria

Inclusion Criteria

•Adult females who were previously enrolled in Efficacy of Bitter Blockers on Taste Acceptance in Pediatric Populations Study (Protocol #809789)

Exclusion Criteria

•Women who are pregnant
•Women on drugs with potential serious adverse effects that are mediated through cytochrome P450.

Outcomes

Primary Outcomes

Psychophysical data for taste solutions

Time Frame: 1-2 hours

Primary outcome variables are intensity ratings of pediatric medications as well as a variety of generally recognized as safe bitter and non-bitter compounds.