A Trial to Assess the Effect of an Intervention Integrating Contingency Management (Financial Incentives) to Enhance Hepatitis C Treatment Uptake Following Dried Blood Spot Hepatitis C RNA Testing Among People With Recent Injecting Drug Use Attending Needle and Syringe Programs

Not Applicable

• Conditions: Hepatitis C, Chronic
• Interventions: Behavioral: Incentive payment

• Registration Number: NCT04428346
• Lead Sponsor: Kirby Institute

Brief Summary

A pilot two-arm, individual-level, randomised controlled trial to assess the effect of an intervention integrating contingency management (financial incentives) to enhance hepatitis C treatment uptake following dried blood spot hepatitis C RNA testing among people with recent injecting drug use attending needle and syringe programs: the AMPLIFY study

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2020-05-10
• Study First Submitted QC: 2020-06-09
• Study First Posted: 2020-06-11
• Status Verified: 2022-04
• Last Update Submitted: 2022-04-13
• Last Update Posted: 2022-04-14
• Study Start: 2022-10
• Primary Completion: 2023-09
• Study Completion: 2023-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 400

Inclusion Criteria

1. Participants have voluntarily signed the informed consent form
2. 18 years of age or older
3. Recent injecting drug use (previous six months)

Exclusion Criteria

1. Inability or unwillingness to provide informed consent

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Contigency Management (Intervention)	Incentive payment	-

Primary Outcome Measures

Name	Time	Method
The proportion of participants who initiate Hepatitis C Virus treatment within 12 weeks of testing	6 months	Data will be presented in percentages and mean (SD) or median values (interquartile range), as appropriate. Chi square test or Fisher's exact test will be utilised, as appropriate, to examine between group differences.

Secondary Outcome Measures

Name	Time	Method
Feasibility of recruitment through a peer-based referral incentivization scheme	6 months	Recruitment numbers
Time to HCV treatment initiation	6 months
Participant perceptions and acceptability of being involved in a contingency management study will be assessed by study questionnaire	6 months
Feasibility of a contingency management intervention to enhance hepatitis C treatment uptake	6 months	Proportion of participants who enrolled in the study and where assigned treatment who commenced treatment.
Time to HCV treatment completion	6 months
Time to visit to confirm viral cure (e.g. sustained virological response, SVR12)	6 months