The Influence of Daily Activities on Retinal Microcirculation in Normal Adults
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 54
- 试验地点
- 1
- 主要终点
- Vessel area density (VAD)
研究概览
简要总结
The daily behaviors such as drinking coffee, wine, reading, exercise and body postural changes may have influence on the function or morphology of the retinal microcirculation in healthy people.A recent study found that the fingertips microvascular bed constricted obviously after the intake of a cup of coffee with caffeine, it significantly reduced blood flow to the fingers; Long reading of electronic products can induce significant dry eye symptoms, affect visual quality, and cause asthenopia. Microcirculation is critical for regulating vascular resistance and blood flow in organs. Fundus blood vessels is the only visible microvascular in vivo, its morphology and function changes not only associated with eye disease, but also with cardiovascular and cerebrovascular diseases. Optical coherence tomography angiography (OCTA) is a new technique which could acquire blood flow information in a non-invasive way without the use of dye. Magnetic resonance imaging (MRI) can quantitatively evaluation of cerebral blood flow and retina-choroid blood flow using the noninvasive arterial spin labeling technique in a large field of view (FOV) without depth limitations.The study tried to detect the influence of daily behaviors such as drinking coffee, red wine, reading , exercise, etc. on the retinal microcirculation with OCTA and MRI, and provide reference for health behaviors.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Single (Outcomes Assessor)
盲法说明
Data analyzers are blind to the participants classification
入排标准
- 年龄范围
- 18 Years 至 35 Years(Adult)
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy adults
- •The age range was from 18 to 35 years old
- •Without another eye disease besides ametropia
- •The spherical equivalent is equal or above minus 3.00 diopters
- •No smoking or drinking
- •Average daily caffeine consumption no more than 1 cup of coffee
- •No diabetes, hypertension, heart disease, liver or kidney dysfunction
- •No medication taken recently
排除标准
- •Mental disorders such as depression and anxiety
- •Intellectual disabilities
- •Female in menstruation, gestation period, perinatal period or lactation period
- •Unable to cooperate with eye examinations and test procedures
- •Heart disease, hypertension, diabetes, liver and kidney dysfunction and other chronic diseases
- •Patients with fever, acute infectious diseases
- •Other conditions that are not suitable for drinking alcohol or coffee, such as allergic to alcohol or coffee
研究组 & 干预措施
Body motion
Exercise and body postural changes.
干预措施: Body motion (Behavioral)
Beverage consumption
Drink 300ml red wine (alcohol concentration:12.5%), 300ml coffee (caffeine concentration 72 mg), 300 ml Baijiu (Chinese liquor, alcohol concentration:12.5%) , SipSparkTM Probiotics (facilitates ethanol degradation) was taken 0.5 hour prior to Baijiu consumption, or 300ml water.
干预措施: Beverage consumption (Behavioral)
Daily reading
Reading paper books, playing video games with mobile phones, or non-reading.
干预措施: Daily reading (Behavioral)
结局指标
主要结局
Vessel area density (VAD)
时间窗: 3 weeks
VAD is calculated as a unit-less ratio of the total image area occupied by the vasculature to the total image area in the binary vessel maps.
Cerebral blood flow (CBF)
时间窗: 3 weeks
The frontal lobe was selected as the region of interest (ROI) to measure and average the changes in CBF
Vessel diameter index (VDI)
时间窗: 3 weeks
VDI is calculated using both the vessel area map and the skeletonized vessel map, to yield the averaged vessel caliber.
Flow impairment region (FIR)
时间窗: 3 weeks
FIZ: calculated by summing all 'no-flow' pixels up.
Retina-choroid blood flow
时间窗: 3 weeks
Blood flow for the entire retinal thickness were determined as a function of the distance from the optic nerve head, where the blood flow was measured at the peaks of the projection profiles. An region of interest outlining the posterior retina with a size of 0.7 to 0.8 mm across the retina-choroid thickness in the parafoveal region was used to obtain the blood flow signal time courses and averaged the values.
次要结局
未报告次要终点
研究者
Jiannan Huang
Director
Shanghai Eye Disease Prevention and Treatment Center
