NL-OMON45639已完成不适用
Vascular reactivity as a surrogate marker in CADASIL - Vascular reactivity in CADASI
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 46
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18 至 64（—）
入选标准
- •- participant in baseline 2000 study (P80/98)
- •- Aged above 18 years
- •- NOTCH3 mutation status known OR partner of a CADASIL patient
排除标准
- •contra-indication for MRI scanning:
- •- Claustrophobia
- •- Pacemakers or defibrillators
- •- Nerve stimulators
- •- Intracranial clips
- •- Intraorbital or intraocular metallic fragments
- •- Cochlear implants
- •- Ferromagnetic implants
- •- Hydrocephalus pump
- •- Intra-utrine device (not all types)
- •- Permanent make-up
- •- Tattoos above the shoulders (only those older than 20 years);Contra- indication for fMRI:
- •- Seizure within prior year.
- •- Non-correctable visual impairment.;Contra- indications for acetazolamide challenge:
- •- Steven-Johnsons syndrome
- •- Individuals from Japanese or Indian descent
- •- Known allergy to sulphonamides
- •- Known severe liver or renal insufficiency
- •- Known occlusion of the a. vertebralis, basilaris or carotis
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