Smoking: a Risk Factor for Pulmonary Arterial Hypertension? A D-A-CH Pulmonary Hypertension Study (Germany- Austria - Switzerland)
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 500
- 试验地点
- 9
- 主要终点
- Difference in Prevalence of Smoking history in patients with PAH compared to unaffected general population
研究概览
简要总结
Environmental factors may play a role in the genesis of pulmonary hypertension, especially in endothelial dysfunction. One widespread environmental factor associated with systemic endothelial dysfunction is cigarette smoke. It may well be that cigarette smoking is not only a risk factor for systemic but also for pulmonary vascular diseases and herewith may interact with other risk factors such as a genetic background and associated conditions. The existing studies which deal with this subject are only small single center case control studies providing less data. Therefore a large European multicenter study is necessary.
The investigators hypothesis are:
- a history of tobacco smoke exposure is highly prevalent in patients with PAH compared to the unaffected general population.
- a history of tobacco smoke exposure is more prevalent in patients with PAH compared to CTEPH.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •pulmonary artery pressure >25mmHg
- •pulmonary capillary occlusion pressure ≤15mmHg
排除标准
- •pulmonary artery pressure <25mmHg
- •pulmonary capillary occlusion pressure >15mmHg
结局指标
主要结局
Difference in Prevalence of Smoking history in patients with PAH compared to unaffected general population
时间窗: Assessment during outpatient consultation, an expected average of 1 day.
Patients will be asked with a specific questionnaire concerning their tobacco smoke exposure and smoking history. Control-group: Data from Swiss health survey (SHS) 2007 (Gesundheitsbefragung Schweiz).
次要结局
未报告次要终点