跳至主要内容
临床试验/NCT03374605
NCT03374605撤回不适用

Modulating Context Generalization Through Transcranial Direct Current Stimulation

Butler Hospital1 个研究点 分布在 1 个国家开始时间: 2018年2月1日最近更新:
适应症
干预措施

试验速览

阶段
不适用
状态
撤回
试验地点
1
主要终点
Relative frequency of selection of task-specific stimuli

研究概览

简要总结

Behavioral adaptation is particularly relevant to anxiety and related disorders, where exposure-based therapies rely on such adaptation as part of behavior therapy.. However, while initial fear reactions generalize easily across contexts, subsequent adaption of behavior through learning is context-specific. The primary goal of this study is to investigate whether transcranial direct current stimulation (tDCS) can be used to acutely impact generalization of subsequent learning across contexts in an experimental paradigm. As part of this study, participants will complete a clinical interview and questionnaires, as well as a computer task asking them to make choices between stimuli on the screen and during which they may or may not receive tDCS.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Basic Science
盲法
Single (Participant)

入排标准

年龄范围
18 Years 至 55 Years(Adult)
性别
All
接受健康志愿者
否

入选标准

  • •Primary diagnosis of an anxiety or related disorder, (defined as panic disorder, social anxiety disorder, generalized anxiety disorder, obsessive-compulsive disorder, and/or post-traumatic stress disorder);
  • •aged 18-55;
  • •ability to speak, read, write, and understand English sufficiently well to complete study procedures and provide informed consent;
  • •Stable psychiatric medication use for at least 6 weeks.

排除标准

  • •Lifetime history of psychotic symptoms or bipolar disorder,
  • •Current substance use disorder;
  • •Acute suicidality or homicidality,
  • •Significant neurological disorder,
  • •Any problems that would interfere with study participation, significant or unstable medical disorders and tDCS-related contraindications (e.g., implanted metallic substances, pregnancy, holes in the skull, skin abnormalities under stimulation sites).

研究组 & 干预措施

Active tDCS

Experimental

干预措施: active tDCS (Device)

Sham tDCS

Sham Comparator

干预措施: sham tDCS (Device)

结局指标

主要结局

Relative frequency of selection of task-specific stimuli

时间窗: 1 hour (measurement occurs 1 time only)

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Sponsor

研究点 (1)

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