Extracorporeal Membrane Oxygenation in Coronavirus Disease (COVID-19), Influenza and ARDS of Other Ethiologies

Completed

• Conditions: COVID-19; Influenza; ARDS

• Registration Number: NCT05353725
• Lead Sponsor: University Medical Centre Ljubljana

Brief Summary

A comparison of clinical characteristics and outcomes of patients on extracorporeal membrane oxygenation (ECMO) in COVID-19, influenza and ARDS of other ethiologies

Detailed Description

All ARDS patients on extracorporeal membrane oxygenation (ECMO) during January 1st 2016 and January 10th 2022 in University Medical Center Ljubljana were included and their clinical characteristics and outcomes were studied according to ARDS ethiology: COVID-19, influenza and other ethiologies.

Study Timeline

• Study Start: 2016-01-01
• Primary Completion: 2022-02-10
• Study Completion: 2022-03-01
• Status Verified: 2022-04
• Study First Submitted: 2022-04-28
• Study First Submitted QC: 2022-04-28
• Study First Posted: 2022-04-29
• Last Update Submitted: 2022-04-29
• Last Update Posted: 2022-05-05

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• Patient with acute respiratory distress syndrome (ARDS) on extracorporeal membrane oxygenation (ECMO)
• 18 years or older

Exclusion Criteria

• Patient not eligible for ECMO treatment per institutional guidelines (terminal illness, palliative care)

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
180-day survival	From day of ECMO-implant for every 24 hours until date of death or survival at 180 days	180-day survival from ECMO implantation

Secondary Outcome Measures

Name	Time	Method
Weaning from ECMO	From day of ECMO-implant until date of death or weaning	Weaning from ECMO
ICU survival	From day of ICU-admission for every 24 hours until date of death or survival at ICU discharge	ICU survival from ECMO implantation
90-day survival	From day of ECMO-implant for every 24 hours until date of death or survival at 90 days	90-day survival from ECMO implantation
Days on ECMO	From day of ECMO-implant for every 24 hours until date of weaning or death	Days on ECMO from ECMO implantation
Hospital survival	From day of hospital admission for every 24 hours until date of death or survival at hospital discharge	Hospital survival from ECMO implantation
30-day survival	From day of ECMO-implant for every 24 hours until date of death or survival at 30 days	30-day survival from ECMO implantation
ICU length of stay	From day of ICU-admission for every 24 hours until date of death or date of ICU discharge	ICU length of stay from ECMO implantation