A Study of Daily Oral Orforglipron (LY3502970) Compared With Insulin Glargine in Participants With Type 2 Diabetes and Obesity or Overweight at Increased Cardiovascular Risk
- Conditions
- Type 2 DiabetesObesityOverweight or ObesityOverweightCardiovascular DiseasesChronic Kidney Disease
- Interventions
- Registration Number
- NCT05803421
- Lead Sponsor
- Eli Lilly and Company
- Brief Summary
The main purpose of this study is to determine safety and efficacy of orforglipron compared with insulin glargine in participants with type 2 diabetes and obesity or overweight at increased cardiovascular risk. The study will last approximately 2 years may include up to 27 visits.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ACTIVE_NOT_RECRUITING
- Sex
- All
- Target Recruitment
- 2749
-
Have been diagnosed with type 2 diabetes mellitus (T2DM)
-
Are at least 18 years of age or legal age of consent in the jurisdiction in which the study is taking place, whichever is older.
-
Have HbA1c at screening
- ≥7.0% and ≤10.5% if background diabetes medication does not include a sulfonylurea, or
- ≥7.5% and ≤10.5% if background diabetes medication includes a sulfonylurea.
-
Are on stable treatment of at least 1 and no more than 3 oral antihyperglycemic drugs for at least 90 days before screening. Antihyperglycemic drugs may include metformin, SGLT-2 inhibitors, and/or sulfonylureas
-
Have increased risk for cardiovascular (CV) events due to:
- Coronary heart disease
- Peripheral arterial disease, presumed to be of atherosclerotic origin
- Cerebrovascular disease, presumed to be of atherosclerotic origin
- Chronic kidney disease (CKD)
- Congestive heart failure (CHF) New York Heart Association (NYHA) functional classification II to III
-
Are of stable weight (± 5%) for at least 90 days prior to screening
-
Have a BMI ≥25 kilograms per meter squared (kg/m2) at screening
- Have type 1 diabetes mellitus
- Have had chronic or acute pancreatitis any time prior to screening
- Currently receiving or planning to receive treatment for diabetic retinopathy and/or macular edema (e.g. laster photocoagulation or intravitreal injections of anty-VEGF inhibitors
- Have a known clinically significant gastric emptying abnormality
- Have acute or chronic hepatitis, signs and symptoms of any other liver disease, or blood alanine transaminase (ALT) or aspartate aminotransferase (AST) enzyme level ≥5.0 times the upper limit of normal (ULN) for the reference range, as determined by the central laboratory
- Have had any of the following within 60 days prior to screening: acute myocardial infarction, cerebrovascular accident (stroke), or hospitalization for congestive heart failure
- Have an eGFR <15 mL/min/1.73 m2 as determined at screening
- Have a family (first-degree relative) or personal history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2
- Have been taking any other diabetes medicines other than metformin, SGLT-2 inhibitors, and/or sulfonylureas during the last 90 days
- Have used any weight loss drugs, including herbal or nutritional supplements, within 90 days of screening
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Orforglipron Orforglipron Participants will receive escalated doses of orforglipron orally. Insulin Glargine Insulin Glargine Participants will receive insulin glargine subcutaneously (SC). Doses will be individualized and titrated according to a treat-to-target algorithm.
- Primary Outcome Measures
Name Time Method Time to First Occurrence of Any Major Adverse Cardiovascular Event (MACE-4) [Myocardial Infarction (MI), Stroke, Hospitalization for Unstable Angina, or Cardiovascular (CV) Death] Baseline to End of the Study (Approximate Maximum 104 Weeks) Time to First Occurrence of Any MACE-4 (Myocardial Infarction (MI), Stroke, Hospitalization for Unstable Angina, or Cardiovascular \[CV\] Death)
- Secondary Outcome Measures
Name Time Method Time to First Occurrence of Any MACE-3 Event (MI, Stroke, or CV death) Baseline to End of the Study (Approximately 104 Weeks) Time to First Occurrence of Any MACE-3 Event (MI, Stroke, or CV death)
Change from Baseline in Daily Average 7-point Self-monitoring Blood Glucose (SMBG) Profile Baseline, Week 52 Change from Baseline in Daily Average 7-point SMBG
Percentage of Participants with HbA1c Target Values Less Than (<)7.0% (53 mmol/mol) Week 52 Percentage of Participants with HbA1c Target Values \<7.0% (53 mmol/mol)
Change from Baseline in Body Weight Baseline, Week 52 Change from Baseline in Body Weight
Percent Change from Baseline Body Weight Week 52 Percent Change from Baseline Body Weight
Change from Baseline in Short Form 36 Version 2 (SF-36v2) Acute Form Domain Score Baseline, Week 52 The SF-36v2 acute form is a 36-item generic, participant completed measure designed to assess 8 domains: physical functioning, role-physical, bodily pain, general health, vitality, social functioning, role-emotional, and mental health. Scores of each domain are measured by T-scores, with a mean of 50 and standard deviation of 10; higher scores indicate better levels of function and/or better health.
Pharmacokinetics (PK): Plasma Serum Concentrations of Orforglipron Baseline through Week 52 PK will be estimated based on the population PK model.
Change from Baseline in Hemoglobin A1c (HbA1c) Baseline, Week 52 Change from Baseline in HbA1c
Change from Baseline in Fasting Serum Glucose Baseline, Week 52 Change from Baseline in Fasting Serum Glucose
Trial Locations
- Locations (373)
West Orange Endocrinology
🇺🇸Ocoee, Florida, United States
Peace River Cardiovascular Center
🇺🇸Port Charlotte, Florida, United States
Care Access - Tamarac
🇺🇸Tamarac, Florida, United States
Baycare Clinical Research
🇺🇸Tampa, Florida, United States
Precision Research Center
🇺🇸Tampa, Florida, United States
Care Access - Tampa
🇺🇸Tampa, Florida, United States
Metabolic Research Institute, Inc.
🇺🇸West Palm Beach, Florida, United States
Encore Medical Research - Weston
🇺🇸Weston, Florida, United States
Clinical Research of Central Florida
🇺🇸Winter Haven, Florida, United States
Conquest Research
🇺🇸Winter Park, Florida, United States
Balanced Life Health Care Solutions/SKYCRNG
🇺🇸Lawrenceville, Georgia, United States
Palm Research Center Tenaya
🇺🇸Las Vegas, Nevada, United States
Palm Research Center Sunset
🇺🇸Las Vegas, Nevada, United States
Northern Nevada Endocrinology
🇺🇸Reno, Nevada, United States
Renown South Meadows Medical Center
🇺🇸Reno, Nevada, United States
Juno Research
🇺🇸Houston, Texas, United States
Biopharma Informatic, LLC
🇺🇸McAllen, Texas, United States
Endocrine Ips, Pllc
🇺🇸Houston, Texas, United States
Research Physicians Network, LLC
🇺🇸Houston, Texas, United States
Southern Endocrinology Associates
🇺🇸Mesquite, Texas, United States
Audie L Murphy VA Hospital
🇺🇸San Antonio, Texas, United States
Clinical Trials of Texas, LLC
🇺🇸San Antonio, Texas, United States
Tekton Research - Fredericksburg Road
🇺🇸San Antonio, Texas, United States
VIP Trials
🇺🇸San Antonio, Texas, United States
Consano Clinical Research, LLC
🇺🇸Shavano Park, Texas, United States
Sherman Clinical Research
🇺🇸Sherman, Texas, United States
Northwest Houston Heart Center
🇺🇸Tomball, Texas, United States
Texas Valley Clinical Research
🇺🇸Weslaco, Texas, United States
Advanced Research Institute
🇺🇸Ogden, Utah, United States
Chrysalis Clinical Research
🇺🇸Saint George, Utah, United States
CEDOES
🇧🇷Vitória, Espírito Santo, Brazil
General Hospital of Athens "G. Gennimatas"
🇬🇷Athens, Attikí, Greece
General Hospital of Athens Laiko
🇬🇷Athens, Attikí, Greece
Attikon General University Hospital
🇬🇷Chaidari, Attikí, Greece
General Hospital of Lamia
🇬🇷Lamia, Fthiótida, Greece
G. Gennimatas General Hospital of Thessaloniki
🇬🇷Thessaloniki, Thessaloníki, Greece
Apollo Excelcare Hospital
🇮🇳Guwahati, Assam, India
V.S. General Hospital
🇮🇳Ahmedabad, Gujarat, India
Nirmal Hospital Pvt Ltd.
🇮🇳Surat, Gujarat, India
Victoria Hospital, Bangalore Medical College And Research Institute
🇮🇳Bangalore, Karnataka, India
Wellness clinical Research Vega Baja
🇵🇷Vega Baja, Puerto Rico
Diabdana
🇷🇴Oradea, Bihor, Romania
Centrul Medical Grandmed
🇷🇴Oradea, Bihor, Romania
Mariodiab Clinic
🇷🇴Brasov, Brașov, Romania
C.M.D.T.A. Neomed
🇷🇴Brasov, Brașov, Romania
Nicodiab
🇷🇴Bucharest, București, Romania
Geea Medical Easy Diet
🇷🇴Bucharest, București, Romania
Hightech Medical Services SRL-Centrul pentru Studiul Metabolismului
🇷🇴Bucharest, București, Romania
Centrul Medical NutriLife
🇷🇴Bucharest, București, Romania
Centrul Medical Endocrinologie si Diabet Dr. Paveliu
🇷🇴Bucharest, București, Romania
Centrul Medical Mediab
🇷🇴Târgu-Mureș, Mureș, Romania
Diabmed Dr. Popescu Alexandrina
🇷🇴Ploiești, Prahova, Romania
Cabinet Medical Dr.Geru
🇷🇴Timisoara, Timiș, Romania
CMI Dr.Pletea Noemi SRL
🇷🇴Bacău, Romania
SC Minimed SRL
🇷🇴Bacău, Romania
Milena Sante
🇷🇴Galați, Romania
Diamed Obesity
🇷🇴Galați, Romania
Centrul Medical Consultmed
🇷🇴Iași, Romania
Cardiomed Iași
🇷🇴Iași, Romania
Clinica Korall
🇷🇴Satu Mare, Romania
IN-DIA
🇸🇰Lučenec, Banskobystrický Kraj, Slovakia
Mersin University
🇹🇷Mersin, Turkey
Adnan Menderes University Medical Faculty
🇹🇷Aydin, Turkey
Dicle Üniversitesi
🇹🇷Diyarbakir, Turkey
Acibadem Universitesi Atakent Hastanesi
🇹🇷Istanbul, Turkey
Erciyes University Medical Faculty
🇹🇷Kayseri, Turkey
İnönü Üniversitesi Turgut Özal Tıp Merkezi
🇹🇷Malatya, Turkey
Rancho Cucamonga Clinical Research
🇺🇸Rancho Cucamonga, California, United States
LCGK Research
🇺🇸San Carlos, California, United States
Pasadena Clinical Research
🇺🇸Pasadena, California, United States
Alliance for Multispecialty Research, LLC
🇺🇸Knoxville, Tennessee, United States
Avalon Medical Group
🇺🇸Muscle Shoals, Alabama, United States
Cahaba Research - Pelham
🇺🇸Pelham, Alabama, United States
Syed Research Consultants Llc
🇺🇸Sheffield, Alabama, United States
The Institute for Liver Health
🇺🇸Chandler, Arizona, United States
Aventiv Research
🇺🇸Mesa, Arizona, United States
Arizona Liver Health - Peoria
🇺🇸Peoria, Arizona, United States
Elite Clinical Studies, LLC
🇺🇸Phoenix, Arizona, United States
Absolute Clinical Research
🇺🇸Phoenix, Arizona, United States
Clinical Research Institute of Arizona (CRI) - Sun City West
🇺🇸Sun City West, Arizona, United States
Orange Grove Family Practice
🇺🇸Tucson, Arizona, United States
KLR Business Group, Inc. dba Arkansas Clinical Research
🇺🇸Little Rock, Arkansas, United States
Hope Clinical Research, Inc.
🇺🇸Canoga Park, California, United States
Valley Clinical Trials, Inc.
🇺🇸Northridge, California, United States
Neighborhood Healthcare Institute of Health
🇺🇸Escondido, California, United States
Valley Research
🇺🇸Fresno, California, United States
NorCal Medical Research, Inc
🇺🇸Greenbrae, California, United States
Orange County Research Center
🇺🇸Lake Forest, California, United States
Ark Clinical Research
🇺🇸Long Beach, California, United States
Pacific Clinical Studies
🇺🇸Los Alamitos, California, United States
Velocity Clinical Research, Westlake
🇺🇸Los Angeles, California, United States
Riverside University Health System - Medical Center
🇺🇸Moreno Valley, California, United States
Infinity Clinical Research - Norco
🇺🇸Norco, California, United States
Velocity Clinical Research, North Hollywood
🇺🇸North Hollywood, California, United States
Mindful Medical Research
🇵🇷San Juan, Puerto Rico
Norcal Endocrinology & Internal Medicine
🇺🇸San Ramon, California, United States
Velocity Clinical Research, Coastal Heart Medical Group
🇺🇸Santa Ana, California, United States
Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
🇺🇸Torrance, California, United States
Diablo Clinical Research, Inc.
🇺🇸Walnut Creek, California, United States
Millennium Clinical Trials
🇺🇸Westlake Village, California, United States
Rocky Mountain Regional VA Medical Center
🇺🇸Aurora, Colorado, United States
University of Colorado Anschutz Medical Campus
🇺🇸Aurora, Colorado, United States
Legacy Clinical Trials
🇺🇸Colorado Springs, Colorado, United States
CMR of Greater New Haven, LLC
🇺🇸Hamden, Connecticut, United States
Orlando Heart & Vascular Institute
🇺🇸Altamonte Springs, Florida, United States
JEM Research Institute
🇺🇸Atlantis, Florida, United States
Excel Medical Clinical Trials
🇺🇸Boca Raton, Florida, United States
Velocity Clinical Research, New Smyrna Beach
🇺🇸Edgewater, Florida, United States
Indago Research & Health Center, Inc
🇺🇸Hialeah, Florida, United States
Nature Coast Clinical Research - Inverness
🇺🇸Inverness, Florida, United States
Northeast Research Institute - Downtown Office
🇺🇸Jacksonville, Florida, United States
Helios Clinical Research - KIS
🇺🇸Kissimmee, Florida, United States
Clinical Site Partners Leesburg
🇺🇸Leesburg, Florida, United States
Panax Clinical Research
🇺🇸Miami Lakes, Florida, United States
L&C Professional Medical Research Institute
🇺🇸Miami, Florida, United States
Adult Medicine of Lake County
🇺🇸Mount Dora, Florida, United States
Renstar Medical Research
🇺🇸Ocala, Florida, United States
Physicians Research Associates
🇺🇸Lawrenceville, Georgia, United States
East Coast Institute for Research, LLC
🇺🇸Macon, Georgia, United States
Clinical Research Atlanta
🇺🇸Stockbridge, Georgia, United States
Rophe Adult and Pediatric Medicine/SKYCRNG
🇺🇸Union City, Georgia, United States
North Georgia Clinical Research
🇺🇸Woodstock, Georgia, United States
Elite Clinical Trials
🇺🇸Rexburg, Idaho, United States
Saltzer Health
🇺🇸Nampa, Idaho, United States
Great Lakes Clinical Trials - Ravenswood
🇺🇸Chicago, Illinois, United States
Midwest CRC
🇺🇸Crystal Lake, Illinois, United States
Affinity Health
🇺🇸Oak Brook, Illinois, United States
NorthShore University Health System
🇺🇸Skokie, Illinois, United States
American Health Network of Indiana, LLC - Avon
🇺🇸Avon, Indiana, United States
Investigators Research Group
🇺🇸Brownsburg, Indiana, United States
Qualmedica Research, LLC
🇺🇸Evansville, Indiana, United States
American Health Network of Indiana, LLC - Franklin
🇺🇸Franklin, Indiana, United States
American Health Network of Indiana, LLC - Greenfield
🇺🇸Greenfield, Indiana, United States
American Health Network of Indiana, LLC - Muncie
🇺🇸Muncie, Indiana, United States
University of Iowa
🇺🇸Iowa City, Iowa, United States
Iowa Diabetes and Endocrinology Research Center
🇺🇸West Des Moines, Iowa, United States
Cotton O'Neil Diabetes & Endocrinology
🇺🇸Topeka, Kansas, United States
Cotton O'Neil Mulvane
🇺🇸Topeka, Kansas, United States
Tekton Research - Wichita
🇺🇸Wichita, Kansas, United States
Qualmedica Research
🇺🇸Bowling Green, Kentucky, United States
L-MARC Research Center
🇺🇸Louisville, Kentucky, United States
Louisiana Heart Center - Convington
🇺🇸Covington, Louisiana, United States
Care Access - Lake Charles (Bayou Pines)
🇺🇸Lake Charles, Louisiana, United States
Maryland Cardiovascular Specialists
🇺🇸Baltimore, Maryland, United States
Endocrine and Metabolic Consultants
🇺🇸Rockville, Maryland, United States
ActivMed Practices and Research
🇺🇸Methuen, Massachusetts, United States
Infinity Medical Research
🇺🇸North Dartmouth, Massachusetts, United States
Revival Research Institute
🇺🇸Dearborn, Michigan, United States
Arcturus Healthcare , PLC, Troy Internal Medicine Research Division
🇺🇸Troy, Michigan, United States
SKY Clinical Research Network Group - Hall
🇺🇸Fayette, Mississippi, United States
SKY Integrative Medical Center/SKYCRNG
🇺🇸Ridgeland, Mississippi, United States
Clinical Research Professionals
🇺🇸Chesterfield, Missouri, United States
Diabetes and Endocrinology Specialists
🇺🇸Chesterfield, Missouri, United States
StudyMetrix Research
🇺🇸Saint Peters, Missouri, United States
Clinvest Research LLC
🇺🇸Springfield, Missouri, United States
Logan Health Research
🇺🇸Kalispell, Montana, United States
Montana Medical Research
🇺🇸Missoula, Montana, United States
Sierra Clinical Research
🇺🇸Las Vegas, Nevada, United States
Las Vegas Medical Research
🇺🇸Las Vegas, Nevada, United States
UniMed Center
🇺🇸East Brunswick, New Jersey, United States
IMA Clinical Research
🇺🇸Albuquerque, New Mexico, United States
Albany Stratton VA Medical Center
🇺🇸Albany, New York, United States
Meridian Clinical Research, LLC
🇺🇸Vestal, New York, United States
SUNY Downstate Health Sciences University
🇺🇸Brooklyn, New York, United States
Velocity Clinical Research, Syracuse
🇺🇸East Syracuse, New York, United States
IMA Clinical Research Westchester
🇺🇸Hartsdale, New York, United States
NYC Research INC
🇺🇸Long Island City, New York, United States
Mid Hudson Medical Research
🇺🇸New Windsor, New York, United States
IMA Clinical Research Manhattan
🇺🇸New York, New York, United States
University of North Carolina Medical Center
🇺🇸Chapel Hill, North Carolina, United States
Care Access - Fayetteville
🇺🇸Fayetteville, North Carolina, United States
PharmQuest Life Sciences, LLC
🇺🇸Greensboro, North Carolina, United States
Lucas Research, Inc
🇺🇸Morehead City, North Carolina, United States
Carolina Research Center
🇺🇸Shelby, North Carolina, United States
Accellacare - Piedmont
🇺🇸Statesville, North Carolina, United States
Accellacare - Wilmington - 1917 Tradd Court
🇺🇸Wilmington, North Carolina, United States
Lillestol Research
🇺🇸Fargo, North Dakota, United States
Remington-Davis, Inc
🇺🇸Columbus, Ohio, United States
Centricity Research Dublin Multispecialty
🇺🇸Dublin, Ohio, United States
Tekton Research, Inc
🇺🇸Yukon, Oklahoma, United States
Central States Research
🇺🇸Tulsa, Oklahoma, United States
Northwest Research Center
🇺🇸Portland, Oregon, United States
Heritage Valley Medical Group, Inc.
🇺🇸Beaver, Pennsylvania, United States
Capital Area Research - Newport
🇺🇸Newport, Pennsylvania, United States
Clinical Research of Philadelphia
🇺🇸Philadelphia, Pennsylvania, United States
Preferred Primary Care Physicians, Preferred Clinical Research-St. Clair
🇺🇸Pittsburgh, Pennsylvania, United States
Preferred Primary Care Physicians
🇺🇸Uniontown, Pennsylvania, United States
The Research Center of The Upstate
🇺🇸Greenville, South Carolina, United States
Care Access - Mauldin
🇺🇸Mauldin, South Carolina, United States
Monument Health Rapid City Hospital
🇺🇸Rapid City, South Dakota, United States
New Phase Research and Development
🇺🇸Knoxville, Tennessee, United States
Tennessee Center for Clinical Trials
🇺🇸Tullahoma, Tennessee, United States
Texas Diabetes & Endocrinology, P.A.
🇺🇸Round Rock, Texas, United States
South Texas Clinical Research
🇺🇸Corpus Christi, Texas, United States
Thyroid, Endocrinology, and Diabetes
🇺🇸Dallas, Texas, United States
Velocity Clinical Research, Dallas
🇺🇸Dallas, Texas, United States
Cardio Voyage
🇺🇸Denison, Texas, United States
Soma Clinical Trials
🇺🇸Wylie, Texas, United States
Epic Medical Research - DeSoto
🇺🇸DeSoto, Texas, United States
Care United Research
🇺🇸Forney, Texas, United States
Diabetes and Thyroid Center of Ft. Worth
🇺🇸Fort Worth, Texas, United States
Valley Institute of Research - Fort Worth
🇺🇸Fort Worth, Texas, United States
Victorium Clinical Research - Houston
🇺🇸Houston, Texas, United States
Wasatch Clinical Research, LLC
🇺🇸Salt Lake City, Utah, United States
Velocity Clinical Research, Salt Lake City
🇺🇸West Jordan, Utah, United States
Kalo Clinical Research
🇺🇸West Valley City, Utah, United States
Manassas Clinical Research Center
🇺🇸Manassas, Virginia, United States
Virginia Research Center
🇺🇸Midlothian, Virginia, United States
Eastern Virginia Medical School (EVMS) Strelitz Diabetes Research Center
🇺🇸Norfolk, Virginia, United States
Centricity Research Suffolk Family Medicine
🇺🇸Suffolk, Virginia, United States
Eastside Research Associates
🇺🇸Redmond, Washington, United States
Multicare Institute for Research and Innovation
🇺🇸Spokane, Washington, United States
Universal Research Group
🇺🇸Tacoma, Washington, United States
St. Vincent Hospital d/b/a Prevea Health
🇺🇸Green Bay, Wisconsin, United States
Clinical Investigation Specialists
🇺🇸Kenosha, Wisconsin, United States
Organizacion Medica de Investigacion
🇦🇷Caba, Buenos Aires, Argentina
Centro Privado de Medicina Familiar / Mindout Research
🇦🇷Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina
CIPREC
🇦🇷Buenos Aires, Ciudad Autónoma De Buenos Aires, Argentina
Centro Médico Viamonte
🇦🇷Buenos Aires, Ciudad Autónoma De Buenos Aires, Argentina
Mautalen Salud e Investigación
🇦🇷Buenos Aires, Ciudad Autónoma De Buenos Aires, Argentina
Glenny Corp. S.A.
🇦🇷Buenos Aires, Ciudad Autónoma De Buenos Aires, Argentina
Centro Medico Dra. Laura Maffei- Investigacion Clinica Aplicada
🇦🇷Ciudad Autonoma de Buenos Aires, Ciudad Autónoma De Buenos Aires, Argentina
Polo de Salud Vistalba
🇦🇷Luján de Cuyo, Mendoza, Argentina
Mgcendo Llc
🇵🇷San Juan, Puerto Rico
Centro de Investigaciones Clínicas Baigorria
🇦🇷Granadero Baigorria, Santa Fe, Argentina
Instituto Médico Catamarca IMEC
🇦🇷Rosario, Santa Fe, Argentina
Investigaciones Clínicas Tucumán
🇦🇷San Miguel de Tucuman, Tucumán, Argentina
Buenos Aires Macula S.A
🇦🇷Buenos Aires, Argentina
CEMEDIC
🇦🇷Buenos Aires, Argentina
Cardiología Palermo
🇦🇷Buenos Aires, Argentina
CENUDIAB
🇦🇷Ciudad Autónoma de Buenos Aires, Argentina
Hospital San Roque
🇦🇷Córdoba, Argentina
Centro de Investigaciones Clinicas Instituto del Corazon (CICIC)
🇦🇷Córdoba, Argentina
Krankenhaus St. Josef Braunau
🇦🇹Braunau, Oberösterreich, Austria
Konventhospital der Barmherzigen Brüder Linz
🇦🇹Linz, Oberösterreich, Austria
Medizinische Universität Graz
🇦🇹Graz, Steiermark, Austria
Medizinische Universitaet Innsbruck
🇦🇹Innsbruck, Tirol, Austria
VIVIT
🇦🇹Feldkirch, Vorarlberg, Austria
Zentrum für klinische Studien Dr Hanusch Gmbh
🇦🇹Vienna, Wien, Austria
Universitaetsklinikum Allgemeines Krankenhaus Wien
🇦🇹Vienna, Wien, Austria
Private Practice - Dr. Evelyn Fliesser-Gorzer
🇦🇹Sankt Stefan ob Stainz, Austria
Klinik Landstraße
🇦🇹Wien, Austria
Klinik Hietzing
🇦🇹Wien, Austria
Instituto de Estudos e Pesquisas Clinicas do Ceara IEP-CE
🇧🇷Fortaleza, Ceará, Brazil
Centro de Pesquisa Clinica do Brasil
🇧🇷Brasilia, Distrito Federal, Brazil
Hospital Brasilia
🇧🇷Brasilia, Distrito Federal, Brazil
Hospital Moinhos de Vento
🇧🇷Porto Alegre, Rio Grande Do Sul, Brazil
Núcleo de Pesquisa Clínica do Rio Grande do Sul
🇧🇷Porto Alegre, Rio Grande Do Sul, Brazil
Centro de Pesquisa Clinica do Coracao
🇧🇷Acaraju, Sergipe, Brazil
Instituto de Pesquisa clinica de Campinas
🇧🇷Campinas, São Paulo, Brazil
Centro de Pesquisa Sao Lucas
🇧🇷Campinas, São Paulo, Brazil
Loema Instituto de Pesquisa Clinica
🇧🇷Campinas, São Paulo, Brazil
Pesquisare Saude
🇧🇷Santo André, São Paulo, Brazil
CPCLIN
🇧🇷Sao Paulo, São Paulo, Brazil
ISPEM - Instituto São José dos Campos em Pesquisas Médicas
🇧🇷São José dos Campos, São Paulo, Brazil
IBPClin - Instituto Brasil de Pesquisa Clínica
🇧🇷Rio de Janeiro, Brazil
NotreDame Intermedica Saude S.A
🇧🇷São Paulo, Brazil
BR Trials - Ensaios Clinicos e Consultoria
🇧🇷São Paulo, Brazil
Hospital 9 De Julho
🇧🇷São Paulo, Brazil
Instituto Dante Pazzanese de Cardiology
🇧🇷São Paulo, Brazil
EFERTUS healthcare s.r.o.
🇨🇿Brno-Bystrc, Brno-město, Czechia
MUDr. Tomas Edelsberger
🇨🇿Krnov, Moravskoslezský Kraj, Czechia
EDUMED - Broumov
🇨🇿Broumov, Náchod, Czechia
EDUMED - Jaroměř
🇨🇿Jaroměř, Náchod, Czechia
AIDIN VK s.r.o.
🇨🇿Hranice, Olomoucký Kraj, Czechia
Private Practice - Dr. Miroslav Koliba
🇨🇿Ostrava, Ostrava Město, Czechia
Diahelp s.r.o
🇨🇿Pardubice V, Pardubice, Czechia
MEDICON
🇨🇿Prague, Praha 4, Czechia
Milan Kvapil s.r.o., Diabetologicka ambulance
🇨🇿Praha, Praha 4, Czechia
EUC Klinika Praha
🇨🇿Prague 5, Praha 5, Czechia
Nefromed
🇨🇿Prague, Praha 6, Czechia
MUDr. Barbora Diepoltova
🇨🇿Praha 9 - Klanovice, Praha 9, Czechia
FLEDIP s.r.o.
🇨🇿Prague, Praha, Hlavní Mešto, Czechia
DiaVize s.r.o.
🇨🇿Praha 4, Praha, Hlavní Mešto, Czechia
Diacentrum Brandys n.L. s.r.o.
🇨🇿Brandys nad Labem, Praha-východ, Czechia
EDUMED - Náchod
🇨🇿Náchod, Czechia
PreventaMed
🇨🇿Olomouc, Czechia
Dialine - Interni a diabetologicka ambulance
🇨🇿Pilsen, Czechia
MUDr. Michala Pelikanova s.r.o.
🇨🇿Praha 4, Czechia
Praglandia s.r.o
🇨🇿Praha 5, Czechia
Nemocnice Cesky Krumlov
🇨🇿Český Krumlov, Czechia
Masarykova Nemocnice V Usti Nad Labem
🇨🇿Rumburk, Ústecký Kraj, Czechia
Hegau-Bodensee-Klinikum Singen
🇩🇪Singen (Hohentwiel), Baden-Württemberg, Germany
Gemeinschaftpraxis Dr. med. Martin Prohaska und Dr. med. Felix Schulte
🇩🇪Mühldorf, Bayern, Germany
Diabetes Zentrum Dr. Tews
🇩🇪Gelnhausen, Hessen, Germany
Diabetologische Schwerpunktpraxis Marck Linn Pickel
🇩🇪Pohlheim, Hessen, Germany
Praxis am Markt - Dr. Bernd Becker
🇩🇪Essen, Nordrhein-Westfalen, Germany
SMO.MD GmbH
🇩🇪Magdeburg, Sachsen-Anhalt, Germany
Gemeinschaftspraxis Dr. Taeschner/Dr. Bonigut
🇩🇪Leipzig, Sachsen, Germany
RED-Institut GmbH
🇩🇪Oldenburg, Schleswig-Holstein, Germany
Diabetespraxis Dr. Braun
🇩🇪Berlin, Germany
Gemeinschaftspraxis für Diabetologie
🇩🇪Eisenach, Germany
MVZ im Altstadt-Carree Fulda GmbH
🇩🇪Fulda, Germany
Schwerpunktpraxis für Diabetes Hormone & Stoffwechsel
🇩🇪Hof, Germany
Medic-Center Nürnberg - Schöll & Kollegen
🇩🇪Nürnberg, Germany
Praxis Dr. Veronika Wenzl-Bauer
🇩🇪Rehlingen, Germany
Iatriko Paleou Falirou Medical Center
🇬🇷Paleo Faliro, Attikí (Region), Greece
Life Care Hospital and Research Centre
🇮🇳Bangalore, Karnataka, India
Karnataka Institute of Medical Sciences
🇮🇳Hubli, Karnataka, India
King Edward Memorial Hospital & Seth Gordhandas Sunderdas Medical College
🇮🇳Mumbai, Maharashtra, India
Central India Cardiology and Research Institute
🇮🇳Nagpur, Maharashtra, India
Chellaram Diabetes Institute
🇮🇳Pune, Maharashtra, India
S C B Medical College and Hospital
🇮🇳Cuttack, Odisha, India
Sawai Man Singh Medical College Hospital (SMS Hospital)
🇮🇳Jaipur, Rajasthan, India
Eternal Heart Care Center and Research Institute
🇮🇳Jaipur, Rajasthan, India
Università degli Studi Gabriele D' Annunzio
🇮🇹Chieti, Abruzzo, Italy
University of Naples Federico II
🇮🇹Naples, Campania, Italy
Azienda sanitaria universitaria giuliano isontina ASUGI Ospedale Maggiore- Università di Trieste
🇮🇹Trieste, Friuli-Venezia Giulia, Italy
Azienda Ospedaliero Universitaria Senese
🇮🇹Siena, Toscana, Italy
AO Santa Maria della Misericordia
🇮🇹Perugia, Umbria, Italy
Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII
🇮🇹Bergamo, Italy
AOU Renato Dulbecco
🇮🇹Catanzaro, Italy
Ospedale San Raffaele
🇮🇹Milano, Italy
Azienda Ospedaliero Universitaria Maggiore della Carità
🇮🇹Novara, Italy
Fondazione Policlinico Universitario Agostino Gemelli IRCCS - Università Cattolica del Sacro Cuore
🇮🇹Roma, Italy
Wonju Severance Christian Hospital
🇰🇷Wonju, Kang-won-do, Korea, Republic of
Yonsei University-Wonju Severance Christian Hospital
🇰🇷Wonju, Kang-won-do, Korea, Republic of
Hanyang University Guri Hospital
🇰🇷Guri-si, Kyǒnggi-do, Korea, Republic of
Seoul National University Bundang Hospital
🇰🇷Seongnam, Kyǒnggi-do, Korea, Republic of
Yeungnam Univeristy Medical Center
🇰🇷Gyeongsan-si, Kyǒngsangbuk-do, Korea, Republic of
Nowon Eulji Medical Center, Eulji University
🇰🇷Seoul, Seoul-teukbyeolsi [Seoul], Korea, Republic of
Seoul National University Hospital
🇰🇷Seoul, Seoul-teukbyeolsi [Seoul], Korea, Republic of
Kangbuk Samsung Hospital
🇰🇷Seoul, Seoul-teukbyeolsi [Seoul], Korea, Republic of
Severance Hospital, Yonsei University Health System
🇰🇷Seoul, Seoul-teukbyeolsi [Seoul], Korea, Republic of
Kyung Hee University Hospital at Gangdong
🇰🇷Seoul, Seoul-teukbyeolsi [Seoul], Korea, Republic of
The Catholic Univ. of Korea Seoul St. Mary's Hospital
🇰🇷Seoul, Seoul-teukbyeolsi [Seoul], Korea, Republic of
Eulji University Hospital
🇰🇷Daejeon, Taejǒn-Kwangyǒkshi, Korea, Republic of
Ulsan University Hospital
🇰🇷Ulsan, Ulsan-Kwangyǒkshi, Korea, Republic of
Centro de Investigacion Cardiovascular y Metabólica
🇲🇽Tijuana, Baja California, Mexico
Instituto Cardiovascular de León S.C.
🇲🇽León, Guanajuato, Mexico
Diseno y Planeacion en Investigacion Medica
🇲🇽Guadalajara, Jalisco, Mexico
Private Practice - Dr. Francisco Gerardo Padilla
🇲🇽Guadalajara, Jalisco, Mexico
Instituto de Diabetes, Obesidad y Nutricion
🇲🇽Cuernavaca, Morelos, Mexico
Cardiolink Clin Trials
🇲🇽Monterrey, Nuevo León, Mexico
Centro Para El Desarrollo de La Medicina Y de Asistencia Medica Especializada S.C.
🇲🇽Culiacán, Sinaloa, Mexico
Centro de Estudios de Investigacion Metabolicos y Cardiovasculares
🇲🇽Ciudad Madero, Tamaulipas, Mexico
Clínica San Cosme
🇲🇽Aguascalientes, Mexico
Centro de Investigación Cardiometabólica de Aguascalientes
🇲🇽Aguascalientes, Mexico
Investigacion En Salud Y Metabolismo Sc
🇲🇽Chihuahua, Mexico
Lahoja. Asociacion Para La Investigacion Y La Farmacovigilancia
🇲🇽Durango, Mexico
Centro de Estudios Clínicos de Querétaro (CECLIQ)
🇲🇽Querétaro, Mexico
Centro de Endocrinologia y Nutricion
🇵🇷Caguas, Puerto Rico
Dorado Medical Complex
🇵🇷Dorado, Puerto Rico
Manati Center for Clinical Research
🇵🇷Manati, Puerto Rico
Puerto Rico Medical Research
🇵🇷Ponce, Puerto Rico
Research and Cardiovascular Corp.
🇵🇷Ponce, Puerto Rico
GCM Medical Group, PSC - Hato Rey Site
🇵🇷San Juan, Puerto Rico
Metabol KLINIK
🇸🇰Bratislava, Bratislavský Kraj, Slovakia
Diacrin s.r.o.
🇸🇰Bratislava, Bratislavský Kraj, Slovakia
MediVet s.r.o.
🇸🇰Malacky, Bratislavský Kraj, Slovakia
Human Care s.r.o.
🇸🇰Kosice, Košický Kraj, Slovakia
Tatratrial s.r.o.
🇸🇰Rožňava, Košický Kraj, Slovakia
Areteus s.r.o.
🇸🇰Trebisov, Košický Kraj, Slovakia
MEDI-DIA s.r.o.
🇸🇰Sabinov, Prešovský Kraj, Slovakia
DIA-MED CENTRUM s.r.o.
🇸🇰Puchov, Trenčiansky Kraj, Slovakia
JAL
🇸🇰Trnava, Trnavský Kraj, Slovakia
Diab - Int
🇸🇰Bytca, Žilinský Kraj, Slovakia
NEDÚ - Národný endokrinologický a diabetologický ústav n.o.
🇸🇰Lubochna, Žilinský Kraj, Slovakia
CHUAC-Complejo Hospitalario Universitario A Coruña
🇪🇸A Coruña, A Coruña [La Coruña], Spain
Hospital Universitario Reina Sofia
🇪🇸Cordoba, Andalucía, Spain
Hospital Universitario Central de Asturias
🇪🇸Oviedo, Asturias, Principado De, Spain
Hospital Universitario Marqués de Valdecilla
🇪🇸Santander, Cantabria, Spain
Complejo Hospitalario Ruber Juan Bravo
🇪🇸Madrid, Madrid, Comunidad De, Spain
Hospital Universitario Quironsalud Madrid
🇪🇸Pozuelo de Alarcón, Madrid, Spain
Vithas Hospital Sevilla
🇪🇸Seville, Sevilla, Spain
Hospital Universitario de La Ribera
🇪🇸Alzira, Valenciana, Comunitat, Spain
Hospital General de Segovia
🇪🇸Segovia, Spain
Clínica nuevas Tecnologías en Diabetes y Endocrinología (NTDE)
🇪🇸Sevilla, Spain
Hospital Universitario Virgen Del Rocio
🇪🇸Sevilla, Spain
Baskent University Dr. Turgut Noyan Research and Training Center
🇹🇷Yuregir, Adana, Turkey
Pamukkale University Medical Faculty, Fahri Goksin Oncology Centre
🇹🇷Pamukkale, Denizli, Turkey
TC Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi
🇹🇷Kadikoy, İstanbul, Turkey
Ankara Universitesi Tip Fakultesi Hastanesi
🇹🇷Ankara, Turkey