Recurrent Failures in assIsted Reproductive Techniques (The FIRST Registry)
- Conditions
- Infertility
- Registration Number
- NCT02685800
- Lead Sponsor
- Casa Sollievo della Sofferenza IRCCS
- Brief Summary
Assisted Reproductive Technologies (ARTs) are widely used in couples with fertility problems. However, despite ART treatment options have evolved over time, the implantation rate remains rather low.
A possible role for inherited and acquired thrombophilias has been invoked, especially in women with previous implantation failures. However, several factors could play a role in these conditions.
A potential benefit of low-molecular-weight heparin (LMWH) in improving ART outcomes, independently of the presence of thrombophilia, has been recently suggested.
This register is designed in order to better define all possible variables influencing ART outcome and improve clinical management of women with previous implantation failures. During this study the investigators will collect and evaluate clinical data regarding the first cycle in women with previous ART failures.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- Female
- Target Recruitment
- 624
- 2 or more implantation failures/losses of clinical pregnancies after ART
- ART cycle at enrolment
- Informed consent
- Ovarian hypofunction
- Uterine pathology
- Hydrosalpinges
- Previous inclusion in the study
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Number of live births 10 months
- Secondary Outcome Measures
Name Time Method Number of clinical pregnancies after ART 10 months
Trial Locations
- Locations (1)
IRCCS Casa Sollievo della Sofferenza
🇮🇹San Giovanni Rotondo, Foggia, Italy