European Multicentre Tics in Children Study

Completed

Conditions: Tourette syndrome
Tourette's disorder
10028037

Registration Number: NL-OMON40209

Lead Sponsor: niversitair Medisch Centrum Groningen

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 70

Inclusion Criteria

ONSET Study:
1. First degree relative of person with TS or another chronic tic disorder according to DSM IV-TR criteria (American Psychiatric Association)
2. Aged 3-10 years, male or female
COURSE STUDY:
1. Having TS or another chronic tic disorder according to DSM IV-TR criteria (American Psychiatric Association)
2. Age 3-16 years, male or female;Parents and patients have provided written informed consent and assent as appropriate according to ethical regulation

Exclusion Criteria

ONSET:
1. Presence of tics
2. Presence of OCD
3. Serious medical illness
4. Child treated with antibiotics in the past 1 month.
5. Children and/or parents are unable to understand and comply with protocol.
COURSE:
1. Serious medical illness
2. Child treated with antibiotics in the past 1 month.
3. Children and/or parents are unable to understand and comply with protocol

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main study outcome is onset of tics (ONSET study) and tic exacerbations<br /><br>(COURSE study), as assessed by the Yale Global tic severity scale (YGTSS) plus<br /><br>Premonitory Urge for Tics Scale (PUTS). </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Other main parameters are the presence of obsessive-compulsive symptoms as<br /><br>assessed by the Children*s Yale Brown Obsessive-Compulsive Scale (CY-BOCS) and<br /><br>the presence of GAS in throat swabs.</p><br>