Prevention Bundles for Surgical Site Infections (PREBUSSI): a Multi-center Observational Study.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- Incidence of SSIs
研究概览
简要总结
Surgical site infections (SSIs) are the most complication after a surgical operation and their incidence reaches 20% worldwide. SSIs have been associated to significant morbidity and mortality, high ICU admission rates, increased length of hospital stay, high readmission rates and raised cost. However, there is no registry for SSIs in Greece so far. In addition, it has been considered that almost half of SSIs could be prevented. Therefore, several prevention strategies have been suggested by international health organizations, such as WHO and NICE, that seem to be effective. The aim of the present study is to investigate the effect of 10 prevention bundles on the rate of SSIs, as well their consequences on several financial parameters of the Greek healthcare system.
详细描述
- 1st phase (2 months) → SSIs rate among abdominal surgical operations and reporting of patients' demographics (gender, age, comorbidities), type of surgery (upper GI, HPB, colorectal), surgical approach (open, laparoscopic), urgency classification, operation time, cost, pathogen cultures and antibiotic sensitivity test.
- 2ο phase (10 months) → implementation of 10 prevention bundles:
- Antibiotic delivery 1-1.5 hours before surgical incision and repeat every 4 hours intraoperatively.
- Hair removal with electric hair clippers using single-use bladdes.
- Surgical scrub with Povidone Iodine solution 4% (Betadine Surgical Scrub)
- Skin preparation with chlorexidine alcohol-based antiseptic solution 2%.
- Intraoperative and postoperative (4-6 hours) normothermia (>36οC) using warmed forced-air blankets.
- Perioperative normoglycemia (Glu<200mg/dl) in diabetic patients.
- Single-use drapes and gowns.
- Surgical team glove changing by before skin incision closing.
- Single-layer surgical incision closure with triclosan plus antimicrobial-coated sutures.
- Wound irrigation (skin and subcutaneous fat) with Povidone Iodine solution (Betadine) after abdominal wall closure.
- Implementation check of 10 prevention bundles preoperatively, intraoperatively and postoperatively.
- Clinical assessment on POD 1, 3, 7 and 1 month postoperatively for SSI presence (according to WHO 2018 definition).
- Reporting of patients' demographics (gender, age, comorbidities), type of surgery (upper GI, HPB, colorectal), surgical approach (open, laparoscopic), urgency classification, operation time, length of stay, cost, pathogen cultures and antibiotic sensitivity test.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 99 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age ≥ 18 years old
- •Signed consent from patient or authorized representative
- •Abdominal surgery
- •Open or laparoscopic operations
排除标准
- •Age < 18 years old
- •No signed consent from patient or authorized representative
- •Neck, thoracic, anal, lumbar operations
- •No closure of abdominal wall or open abdomen
结局指标
主要结局
Incidence of SSIs
时间窗: 30 days
Rate of SSIs after implementation of prevention bundles
次要结局
- Pathogen cultures(30 days)
- Antibiotic sensitivity test(30 days)
- Cost(30 days)
- Length of hospital stay(30 days)
- Implementation of guidelines(30 days)
研究者
Maximos Frountzas
Maximos Frountzas MD MPA PhD
National and Kapodistrian University of Athens