The influence of ambient temperature on inflammation in humans.

• Conditions: Healthy men, treated for any co-morbidities.

• Registration Number: CTRI/2018/07/015111
• Lead Sponsor: Ludwik Rydygier Collegium Medicum in Bydgoszcz NicolausCopernicus University in Torun Poland

Brief Summary

This study will assess the impact of postexercise sauna treatment and cold water immersion on inflammation markers in blood. The organism reaction to ambient temperature changes is regulated by a number of substances. Detailed analysis of changes in the concentration of selected interleukins, C-reactive protein and the activity of lysosomal enzymes and protease inhibitor, the substances potentially involved in the body’s reaction to ambient temperature changes, can identify factors that play a key role in the mechanism of adaptation to thermal stress

Detailed Description

Not available

Study Timeline

• Study Start: 2016-04-26
• Last Update Posted: 2018-04-04

Recruitment & Eligibility

• Status: Not Applicable
• Sex: Male
• Target Recruitment: 100

Inclusion Criteria

healthy persons, non-smokers.

Exclusion Criteria

Persons treated for any co-morbidities, smoking cigarettes and using a diet that could affect inflammation rates were excluded from the study.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Examination of patients’ peripheral blood serum activity of arylsulfatase, acid	The experimental material was venous blood taken from the basilic vein into vacuum test | tubes three times for each participant (before exercise, 2 and 20 minutes after exercise): for | blood serum (clot activator and gel separator).
phosphatase, cathepsin D, alpha1-antitrypsin.	The experimental material was venous blood taken from the basilic vein into vacuum test | tubes three times for each participant (before exercise, 2 and 20 minutes after exercise): for | blood serum (clot activator and gel separator).

Secondary Outcome Measures

Name	Time	Method
Examination of patients’ peripheral blood serum concentration of interleukin 6 (IL-6), interleukin 10 (IL-10), tumor necrosis factor α (TNF-α) and transforming growth factor β1 (TGF-β1) and C-reactive protein (CRP)

Trial Locations

Locations (1)

Nicolaus Copernicus University, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Poland; 🇮🇳 24,85-092, India

Nicolaus Copernicus University, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Poland

🇮🇳24,85-092, India

Celestyna MilaKierzenkowska

Principal investigator

48525853740

celestyna@go2.pl