A comparitive study of opioid free anesthesia with opioid base anesthesia for recovery characteristics and postoperative cognitive dysfunction after mastoidectomy surgeries
试验速览
- 阶段
- 2/3 期
- 状态
- 已完成
- 发起方
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- 1)Emergence time
研究概览
简要总结
Opioid free anesthesia is a technique where no intraoperative opioid is administered during anesthetic management and is usually achieved through sympatholysis, analgesia and anesthesia with DEXMEDETOMIDINE. Because of concern that opioids might cause perioperative respiratory depression, substitution with DEXMEDETOMIDINE will be helpful with analgesic and sympatholytic properties. It can allow for faster awakening and thus an earlier neurological examination by decreasing necessary volatile agent and opioid doses.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- Participant and Outcome Assessor Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 65.00 Year(s)（—）
- 性别
- All
入选标准
- •Age between 18 to 65 years ASA physical status 1 and 2.
排除标准
- •Taking opioid for chronic pain Pregnant and nursing women GCS less than 15 and heart rate less than 50 per min Allergic to study medications Psychiatric disorder and electrolyte imbalance Hepatic and renal insufficiency Unstable cardiorespiratory disorder.
结局指标
主要结局
1)Emergence time
时间窗: 1)Emergence time from administration of reversal agent to eye opening | 2)Extubation time from adminstration of reversal agent to tracheal extubation | 3)recovery of cognitive functions assessed using Short Orientation Memory Concentration test ater extubation at 5, 10 and 15mins
2)Extubation time
时间窗: 1)Emergence time from administration of reversal agent to eye opening | 2)Extubation time from adminstration of reversal agent to tracheal extubation | 3)recovery of cognitive functions assessed using Short Orientation Memory Concentration test ater extubation at 5, 10 and 15mins
3)recovery of cognitive functions
时间窗: 1)Emergence time from administration of reversal agent to eye opening | 2)Extubation time from adminstration of reversal agent to tracheal extubation | 3)recovery of cognitive functions assessed using Short Orientation Memory Concentration test ater extubation at 5, 10 and 15mins
次要结局
- 1) Intraoperative hemodynamic stability(2)Postoperative pain assessment)
研究者
Preethi S
Sri Ramachandra Institute Of Higher Education And Research