Effect of Low Tidal Volume on Blood Loss During Laparoscopic Hepatectomy
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 104
- 试验地点
- 1
- 主要终点
- Blood loss
研究概览
简要总结
To explore the effect of low tidal volume on blood loss and gas exchange during laparoscopic hepatectomy
详细描述
Background & Aims:Liver cancer is an disease that threatening human health .Laparoscopic hepatectomy is more and more widely used.It is very important to reduce the bleeding during laparoscopic hepatectomy.The investigators found that low tidal volume can effectively reduce intraoperative bleeding.The aim of this study was to explore the effect of low tidal volume on blood loss and gas exchange during laparoscopic hepatectomy
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Triple (Participant, Care Provider, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Aged from 18 to 70 years old;
- •American association of anesthesiologists(ASA) score I to III;
- •Ability to adhere to the study schedule;
- •Ability to provide informed consent and complete all study assessments;
- •Patients undergoing selective surgery of laparoscopic hepatectomy.
排除标准
- •The New York Heart Association classification(NYHA) III to IV;
- •Chronic obstructive pulmonary disease,respiratory failure, patients after thoracic surgery.
- •BMI>32Kg/m2;
- •Abnormal in blood coagulation function;
- •Patients with mental disease;
- •Patients with neuromuscular disease;
- •Concurrent enrollment in another Randomized controlled trial(RCT);
- •Absence of written informed consent.
研究组 & 干预措施
Low tidal volume group
Use a low tidal volume(6'8ml/kg) ventilation mode during liver segmentation。
干预措施: Tidal volume (Other)
Standard tidal volume group
Use a standard tidal volume(10'12ml/kg) ventilation mode during operation.
干预措施: Tidal volume (Other)
结局指标
主要结局
Blood loss
时间窗: through study completion, an average of 48hours
Blood loss during operation.
次要结局
- mean arterial pressure(During operation)
- oxygenation index(During operation)
- central venous pressure(During operation)
研究者
Shuguo Zheng, MD
Professor of Institute of Hepatobiliary Surgery, Southwest Hospital, Third Military Medical University Affiliation: Southwest Hospital, China
Southwest Hospital, China