Beetroot Enriched Bread, Blood Pressure and Vascular Function
Not Applicable
Completed
- Conditions
- Hypertension
- Interventions
- Dietary Supplement: Bread
- Registration Number
- NCT01706718
- Lead Sponsor
- University of Reading
- Brief Summary
Dietary nitrate is known to lower blood pressure. Beetroot is a rich source of nitrate and could therefore be an important dietary component in the management of hypertension and cardiovascular disease, however consumption is relatively low. We evaluated the effects of beetroot enriched bread ingestion on acute microvascular reactivity, arterial stiffness and blood pressure response in healthy men.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Male
- Target Recruitment
- 24
Inclusion Criteria
- Male
- A signed consent form
- Age 18-64 years
- Body mass index - 18.5-30 kg/m2
- Non-smoking, healthy individuals
- Normal blood pressure at screening (< 150/90)
Exclusion Criteria
- Subjects with anaemia
- Sufferers of chronic illnesses
- Individuals with food allergies
- People with diabetes
- People with coeliac disease
- Women
- Vegetarians
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description Control white bread Bread - Beetroot bread Bread -
- Primary Outcome Measures
Name Time Method Vascular reactivity Change from baseline at 2, 4 and 6 hours after bread consumption Forearm blood flow by Laser Doppler Imaging with iontophoresis
- Secondary Outcome Measures
Name Time Method Arterial stiffness Change from baseline at 2, 4 and 6 hours after bread consumption Pulse wave analysis (PWA) and velocity (PWV)
Blood pressure Change from baseline at 30 minute intervals for 7 hours By ambulatory blood pressure monitor
Plasma nitrate Every 30 minutes for 7 hours Plasma nitrite Every 30 minutes for 7 hours
Trial Locations
- Locations (1)
University of Reading
🇬🇧Reading, Berkshire, United Kingdom