NCT01706718已完成不适用
The Effects of Beetroot Enriched Bread on Postprandial Vascular Function, Arterial Stiffness and Blood Pressure in Healthy Men
适应症
干预措施
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 24
- 试验地点
- 1
- 主要终点
- Vascular reactivity
研究概览
简要总结
Dietary nitrate is known to lower blood pressure. Beetroot is a rich source of nitrate and could therefore be an important dietary component in the management of hypertension and cardiovascular disease, however consumption is relatively low. We evaluated the effects of beetroot enriched bread ingestion on acute microvascular reactivity, arterial stiffness and blood pressure response in healthy men.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Prevention
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 64 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •A signed consent form
- •Age 18-64 years
- •Body mass index - 18.5-30 kg/m2
- •Non-smoking, healthy individuals
- •Normal blood pressure at screening (< 150/90)
排除标准
- •Subjects with anaemia
- •Sufferers of chronic illnesses
- •Individuals with food allergies
- •People with diabetes
- •People with coeliac disease
- •Vegetarians
研究组 & 干预措施
Control white bread
Placebo Comparator
干预措施: Bread (Dietary Supplement)
Beetroot bread
Experimental
干预措施: Bread (Dietary Supplement)
结局指标
主要结局
Vascular reactivity
时间窗: Change from baseline at 2, 4 and 6 hours after bread consumption
Forearm blood flow by Laser Doppler Imaging with iontophoresis
次要结局
- Arterial stiffness(Change from baseline at 2, 4 and 6 hours after bread consumption)
- Blood pressure(Change from baseline at 30 minute intervals for 7 hours)
- Plasma nitrate(Every 30 minutes for 7 hours)
- Plasma nitrite(Every 30 minutes for 7 hours)
研究者
Julie Lovegrove
Professor
University of Reading
研究点 (1)
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