Clinical Presentation of Celiac Disease in Last 14 Years, A Single Center Study
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Cairo University
- Enrollment
- 120
- Locations
- 1
- Primary Endpoint
- Pattern of Clinical Presentations of Pediatric Celiac Disease
Study Overview
Brief Summary
The aim of this study is to:
- To determine the pattern of clinical presentations of celiac disease (CD) over the past 10 - 14 years in Egyptian children.
- To study the various clinical presentation of CD in Egyptian children.
- To evaluate the pattern of CD in relation to different age groups in our children.
- To correlate between the clinical presentations of celiac disease and the upper GIT endoscopic findings.
Detailed Description
Celiac disease (CD) is an immune-mediated systemic disease triggered by intake of gluten and related prolamines in genetically susceptible individuals, characterized by presence of various combinations of small intestinal damages, celiac specific antibodies, human leukocyte antigen (HLA)-DQ2 or HLA-DQ8, and gluten-dependent clinical manifestations. Gluten is found in wheat, barley, rye, and oats.
Study Design
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Cross Sectional
Eligibility Criteria
- Ages
- 6 Months to 15 Years (Child)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Children in the age range from 6 months to 15 years diagnosed with Celiac disease.
Exclusion Criteria
- •Age less than 6 months or more than 15 years.
- •Patients or parents unwilling to share their personal, social and medical data or refuse to participate in the study.
- •Celiac disease patients with other gastrointestinal or non-gastrointestinal diseases (e.g., inflammatory bowel disease) that might interfere with data interpretation.
Arms & Interventions
Study group
Children aged 6 months to 15 years diagnosed with celiac disease and followed at the Pediatric Gastroenterology Clinic of Cairo University Children's Hospital between January 2009 and December 2023. Clinical, laboratory, serological, endoscopic, and histopathological data will be retrospectively extracted from their medical records. Patients will be analyzed according to the period of diagnosis (2009-2011, 2012-2019, or 2020-2023) and age at diagnosis (<2 years, 2-5 years, or >5-15 years).
Intervention: Retrospective Medical Record Review (Other)
Outcomes
Primary Outcomes
Pattern of Clinical Presentations of Pediatric Celiac Disease
Time Frame: 12 months post-procedure
The percentage of children presenting with celiac disease will be determined.
Secondary Outcomes
No secondary outcomes reported
Investigators
Suaad Abukhezam Faraj Abukhezam Mohamed
PhD student
Cairo University