Sustained Low Efficiency Dialysis Versus Continuous Renal Replacement Therapy for Acute Kidney Injury in Critically Ill Cirrhotics-A Pilot Randomized Controlled Trial.

Institute of Liver and Biliary Sciences0 个研究点目标入组 0 人开始时间: 待定最近更新: 2021年11月24日

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•Critically ill cirrhotics with septic shock defined as need of vasopressors to maintain MAP > 65 mm Hg and lacate >2 mmol/L despite adequate fluid resuscitation with severe AKI meeting criteria for dialysis

•1.Patients with age less than 18 years or more than 65 years
•2.Severe known cardiopulmonary disease (structural or valvular heart
•disease, coronary artery disease, COPD, CKD)
•3.Patients with ACLF
•4.Patients with cerebral edema
•5.Patients with refractory shock i.e. requiring norepinephrine or equivalent
•>0.5ug/kg/min
•6.Severe coagulopathy platelets <20,000 and INR >4
•7.Active Bleed (Mucosal or variceal)
•8.Pregnancy
•9.Patients with moderate-severe ARDS i.e. Pa02/Fio2 ratio <200
•10.Extremely moribund patients with an expected life expectancy of less
•than 24 hours
•11.Failure to give informed consent from family members.
•12.Patient enrolled in other clinical trials
•13.Patients with Hepatorenal Syndrome, post renal obstructive AKI, AKI suspected due to glomerulonephritis, interstitial nephritis or vasculitis based on clinical history and urine analysis
•14.Patients who have already been on hemodialysis before their arrival in
•the intensive care unit
•15.Patients with severe vasodilatation SVR <400 dynÂ·s/cm5 and/or lactate
•> 5 mmol/L

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