Risk Factors of Bleeding in Patients Undergoing Peripheral Veno Arterial Extra Corporeal Membrane Oxygenation
概览
- 阶段
- 不适用
- 干预措施
- ECMO
- 疾病 / 适应症
- Extracorporeal Membrane Oxygenation
- 发起方
- Centre Hospitalier Universitaire Dijon
- 入组人数
- 278
- 试验地点
- 1
- 主要终点
- Rate of major hemorrhagic episodes defined as follows: loss of over 2g dl-1 of hemoglobin in 24 h, bleeding rate over 20 ml kg-1 day-1 or blood transfusion over 10 ml kg-1 day-1
- 状态
- 已完成
- 最后更新
- 2个月前
概览
简要总结
Veno arterial extracorporeal membrane oxygenation (VA ECMO) is used, for cardiogenic shock, refractory cardiac arrest and post cardiotomy cardiac failure. Bleeding is frequent complications during VA ECMO and is associated with increased mortality. The aim of our study was to identify early factors associated with major bleeding in patients supported by VA ECMO
研究者
入排标准
入选标准
- •Patients over 18 years treated by peripheral veno arterial membrane oxygenation
排除标准
- 未提供
研究组 & 干预措施
Veno arterial extracorporeal membrane oxygenation
干预措施: ECMO
结局指标
主要结局
Rate of major hemorrhagic episodes defined as follows: loss of over 2g dl-1 of hemoglobin in 24 h, bleeding rate over 20 ml kg-1 day-1 or blood transfusion over 10 ml kg-1 day-1
时间窗: Through study completion, an average of 10 years
Our main objective was to evaluate risk factors independently associated with major hemorrhagic episode. We collected patient characteristics at the start of VA ECMO: age, gender, anthropometric information, medical history and chronic treatments. We also calculated SOFA and APACHE II scores on the day of VA ECMO implementation. We noted the indication for VA ECMO, any pre-cannulation treatments (fibrinolysis, aspirin, heparin), where VA ECMO was inserted and whether or not an intra-aortic balloon pump was present. With regard to various complications, we collected the quantity of delivered blood products , the site of bleeding initial temperature. The biological data were collected at initiation of VA ECMO.
次要结局
- Rate of mortality(30 day)
- Length of stay(Through study completion, an average of 10 years)
- Duration of life support(Through study completion, an average of 10 years)
- Ischemic and thrombotic complications(Through study completion, an average of 10 years)