Contrasting the Neural Systems of Social and Non-social Threat Regulation in the Adolescent Brai

Recruiting

Conditions: Extinction learning
10002861

Registration Number: NL-OMON51563

Lead Sponsor: niversiteit Leiden

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Not specified

Target Recruitment: 200

Inclusion Criteria

- Fluent Dutch speaker
- 9-16 years old
- Right-handed

Exclusion Criteria

- Participants with current use of psychotropic medications (unless they quit
24 hours before participation) or oral contraceptives
- (Possible) pregnancy in females
- Current and/or past psychiatric conditions
- Current and/or past neuroendocrine conditions
- Current and/or past epilepsy or head trauma
- Contraindications for MRI, including: metal implants (including braces),
heart arrhythmia and claustrophobia.

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>In each session participants will undergo a structural MRI scan and an fMRI<br /><br>scan whilst performing tasks. The main study parameter is the Blood Oxygen<br /><br>Level Dependent response (BOLD-response) in the threat regulation brain network<br /><br>during implicit and explicit forms of social versus non-social threat<br /><br>regulation. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>The secondary parameters include:<br /><br>- The resting-state fMRI<br /><br>- Sex-steroid hormones<br /><br>- Fear conditioning response<br /><br>- Reactivity and regulation response<br /><br><br /><br>Other parameters (questionnaires for participants)<br /><br>* Exit questionnaire - perception of observed learning model<br /><br>* Pubertal development<br /><br>* Subtests of an IQ test<br /><br>* Peer influence<br /><br>* General symptoms of psychopathology / anxiety / depression<br /><br>* Early-life stress<br /><br>* Resilience<br /><br>* Sleep<br /><br><br /><br>Other parameters (questionnaires for parents)<br /><br>* Early & current adolescent life events<br /><br>* Socio-Economic Status (SES)<br /><br>* Sleep<br /><br></p><br>